A Lunardini

Renal Calculosis of Pandolfo III Malatesta (1370-1427)

Renal Calculosis of Pandolfo III Malatesta (1370-1427) Valentina Giuffra, PhD, Luca Ventura, MD, Simona Minozzi, PhD, Agata Lunardini, Raimondo Quaresima, Lorenzo Arrizza, Gino Fornaciari, MD Division of Paleopathology, History of Medicine and Bioethics, Department of Oncology, Transplants and Advanced Technologies in edicine, University of Pisa, Italy; Department of Pathology, San Salvatore Hospital, L’Aquila, Italy; Department of Chemistry, hemical Engineering and Materials, University of L’Aquila, Italy; Centre of Electronic Microscopy, University of L’Aquila, Italy.

Metastatic Prostate Carcinoma from Imperial Rome (1st to 2nd Centuries AD)

Objective: This study describes and discusses a rare case of metastatic carcinoma that affected the skeleton of an adult male recovered in the necropolis of Casal Bertone in Rome (Italy). The necropolis, which dates back to the Imperial Age (1st to 2nd century AD), is located near some residential structures and a large place identified as a fullery (fullonica). Methods: Anthropological and paleopathological studies of the skeletal remains were performed via careful macroscopic, microscopic, radiological (X-ray and CT scan), and histological investigation. Results: The skeleton displayed mixed osteoclastic and osteoblastic lesions that mainly involved the axial bones, in particular the sternum, the ribs, the spine, and the scapular and pelvic girdles. The anatomical distribution and the destructive and proliferative nature of the lesions suggested diffuse metastases arising from a soft-tissue primary cancer. The age and sex of the individual, as well as radiographic and histological pictures, allowed diagnosis of an advanced prostate cancer with extensively diffused bone metastases. Conclusion: At present, this is the only case of prostate cancer from the Imperial Age recovered in Rome.