A. M. Bron

Gentamicin, norfloxacin and lysozyme concentration in human tears: in vivo and in vitro study

Abstract Hens egg lysozyme (HEL) activity was measured in vitro with gentamicin and norfloxacin by a turbidimetric technique. Gentamicin at the concentration of 10‐3 M inhibited HEL activity by 39%, while 10‐3 M norfloxacin did not affect HEL activity. However, an in vivo study in healthy persons did not show any significant statistical difference in tear lysozyme activity when 0.3% gentamicin or 0.3% norfloxacin were topically applied.

Intraocular pressure and central corneal thickness in an old French population: The MONTRACHET study

Purpose To describe the distribution of intraocular pressure (IOP) and central corneal thickness (CCT) in an old French population. Methods 9294 individuals 65 years and older were included in the 3C cohort study since 1999 in 3 French cities (Bordeaux, Dijon and Montpellier). In Dijon, an additional ophthalmic examination was performed 10 years after the initial inclusions to assess the relation between systemic age-related diseases and eye diseases in the MONTRACHET Study (Maculopathy Optic Nerve nuTRition neurovAsCular and HEarT diseases). In this population-based study a thorough eye examination and a questionnaire were undertaken in each participant. Intraocular pressure (IOP) was measured with a noncontact pneumotonometer and central corneal thickness (CCT) was measured with an ultrasound pachymeter. Results Among the 1153 participants of the MONTRACHET study only those without an ocular hypotensive treatment and those without evidence of glaucoma based on optic disc photography were considered. Among these individuals, 64% were female and the age was 82.2 ± 3.8 years. IOP in the right eye and the left eye was 14.6 ± 3.2 and 14.8 ± 3.2 mmHg, respectively, p = 0.06.IOP was lower in pseudophakic than in phakic participants 15.2 ± 3.2 and 15.4 ± 3.1 mmHg vs 13.9 ± 3.0 and 14.1 ± 3.1 mmHg for the right and the left eye, respectively, p < 0.01. CCT in the right eye and the left eye was 553.4 ± 34.4 μm and 555.7 ± 34.7 μm, respectively, p < 0.01. CCT was not influenced by the lens status and the refraction error. Conclusion These preliminary results of the MONTRACHET study shed a new light on the relations between IOP and and the lens status in the elderly.

Macular sensitivity and structure in epiretinal membranes 6 months after surgical treatment

Purpose To evaluate the evolution of macular sensitivity (MS) and its correlation with visual acuity (VA) and Spectral‐Domain Optical Coherence Tomography (SD‐OCT) in patients with idiopathic epiretinal membrane (ERM) at 3 and 6 months after surgical treatment.

Choroidal thickness in glaucoma patients and glaucoma suspects measured by spectral domain optical coherence tomography

Purpose The aim of our study was to evaluate and compare retro‐foveolar choroidal thickness (RFCT) of healthy subjects, individuals with intraocular hypertension, patients with primary open‐angle glaucoma (POAG), patients with normal tension glaucoma (NTG) and patients with primary angle‐closure glaucoma (PACG) by spectral domain optical coherence tomography (SD‐OCT).