A. Malihy

Intracardiac Teratoma in an Infant: Report of a New Case and Literature Review

Primitive intracardiac tumours are rare, especially in childhood, and are often discovered on autopsy. The intracardiac teratoma is the rarest intracardiac tumours of childhood. Herein, we report the case of an 11-month-old infant, which featured recurrent bronchoalveolitis since the age of 3 months, with a thoracic deformation. Physical examination did found discrete respiratory distress signs. Chest radiography showed large mediastinal enlargement. The computed tomography showed a solid cystic-cloisonned mass with fat and central calcification highly suggestive of an intracardiac teratoma. A radical surgical excision was made and the histological examination found a well circumscribed tumour containing elements of the three germ layers confirming the diagnosis of mature well-differentiated teratoma, with no need of immunohistochemical support.

Fibroblastome à cellules géantes inhabituel: à propos d’un cas unusuel

Giant cell fibroblastoma (GCF) is a rare superficial tumor occurring in male infants. We report the case of a 3-month old infant examined for a mass in his right arm. Arm MRI objectified a subcutaneous mass. The patient underwent total excision of the mass. Histological, immuno-histochemical and genetic examinations showed giant cell fibroblastoma. This tumor poses diagnostic challenges to the pathologist because it may be confused with malignant mesenchymal tumors with different prognosis.

Néphroblastome botryoïde étendu au duodénum

We report on a rare case of botryoid Wilms tumor extending into the duodenum. This uncommon macroscopic form of nephroblastoma consists entirely of a polypoid renal intrapelvic mass. The main differential diagnosis of this unusual tumor is botryoid rhabdomyosarcoma. A 14-month-old boy presented with a painful abdominal mass. Radiology revealed a large heterogeneous mass in the renal calyx, protruding into the ureter. A right radical nephroureterectomy was carried out. The tumor was found to extend into the 2nd portion of the duodenum. The pathologic diagnosis was mixed type nephroblastoma, SIOP 2001 stage III. The patient was given a course of postoperative chemotherapy. No local recurrence or metastatic spread has been detected after 2 years. Only few such cases have been previously reported, some of them extending into the bladder. To our knowledge, botryoid nephroblastoma has not previously been described as extending into the digestive system.

Intoxication pulmonaire fatale à la bléomycine

Resume La bleomycine est un antibiotique cytotoxique decouvert par Umezewa et al . en 1966 et isole a partir du Streptomyces verticillus . Il est utilise principalement dans le traitement cytostatique de nombreuses tumeurs malignes, notamment dans les chimiotherapies d’induction.Il a moins de risque de myelotoxicite ; cependant, sa toxicite pulmonaire grave et potentiellement mortelle a limite son utilisation et sa dose. Les facteurs de risque incrimines sont la dose cumulative de bleomycine > 300,000 IU, la reduction du taux de filtration glomerulaire, l’augmentation de la creatinemie, l’âge avance et l’exposition a des concentrations elevees d’oxygene dans l’air inspire. Nous rapportons le cas d’un jeune garcon de 15 ans traite par la bleomycine pour un carcinome indifferencie de type nasopharynge et dont l’evolution a ete marquee par l’apparition d’une insuffisance respiratoire rapidement fatale. Cette revue se concentrera sur la toxicite pulmonaire bleomycine-induite, suivie d’une revue de la litterature concernant la pathogenie de la fibrose pulmonaire.