A. Neuman

ETUDE STRUCTURALE DE L'ACIDE BUTANE HYDROXY-1 AMINO-4 DIPHOSPHONIQUE-1,1′

Abstract Structural study using X-Ray Crystallography of the amino hydroxy diphosphonic acid of the title has been done. The final objective is to use this functionalized hydroxy diphosphonic acid in complexation study and in organic synthesis of biological derivatives by the way of the amino group. Results are discussed on the basis of the environment of phosphorus atoms and on the molecular geometry around the central carbon atom.

ETUDE STRUCTURALE DU COMPLEXE DE l′ACIDE ETHANE HYDROXY-1 DIPHOSPHONIQUE-1,1′ AVEC LE CUIVRE II

Abstract Structural study using X-ray cristallography of the complex of the title has been done. Our aim in that study is to be able afterwards to compare it with other cupric complexes dealing with functionalized hydroxy diphosphonic acid and to use these results in the way of organic synthesis. Results are discussed on the basis of the environment of phosphorus atoms and on the molecular geometry around the central carbon atom.

Saradaferin, a new sesquiterpenoid coumarin from Ferula assafoetida

Phytochemical investigation of the gum resin of Ferula assafoetida resulted in the isolation and characterization of a new sesquiterpenoid coumarin, Saradaferin (1) named as [Decahydro-(3-α-hydroxy-4,4,10-trimethyl-8-methylene-9-naphthenyl)-α-hydroxymethyl] ether of umbelliferone.

Supramolecular assembly of substituted hydroxy-bisphosphonates with cupric ion. Influence of the chain functionalization

Abstract As part of a general study of hydroxy-bisphosphonic acids (HEBP), R-C(OH)(PO3H)2, three Cu (II) complexes with R˭CH3; R˭-(CH2)3-NH2 and R˭-(CH2)5-NH2, were prepared and analysed by X-Ray diffraction methods. The substitution of the methyl group in HEBP (3) by an aminopropyl (1) or by an aminopentyl (2) chain led to a drastic modification of the ionic self-assembly in the crystal and completely different polyhedral complexation networks around the Cu (II). A polymeric chain formation is observed in (3), whereas (1) and (2) display discrete tetrameric and dimeric arrangements. The results are discussed on the basis of the environment of the phosphorus atoms and the molecular geometry around the central carbon atom of the hydroxy-bisphosphonic moiety. These results are further compared to their ability for ionic transport and/or extraction.

ÉTUDE DE LA COMPLEXATION DU CADMIUM ET DU ZINC AVEC L'ALENDRONATE (ACIDE 4-AMINO-1-HYDROXYBUTYLIDÈNE-1′1-BISPHOSPHONIQUE)

Abstract Structural study using X-ray cristallography of the complexes of the title has been done. Alendronate is already known to be a very good chelator of divalent cations and supramolecular species obtained with alendronate and these cations are very stable and make them able to be used in biological systems. Our study points out that the size of the cation strongly modifies the structure of the complex. With Cu(II) and Zn(II) which are two cations with proximate ionic radii one cation is put in the centre of the coordination system and structures are isomorphous. On the other hand, with Cd(II), a binuclear complex is obtained. Results are discussed on the basis of these structures.

Cercospora beticola toxins. Part XI1: Isolation and structure of beticolin 0

Abstract Structure of beticolin O has been established through examination of its spectroscopic data including X-Ray diffraction and through its chemical transformation into the previously identified beticolin 2 .

ETUDE STRUCTURALE DU TÉTRAESTER MÉTHYLIQUE DE L'ACIDE ETHANE HYDROXY-1 DIPHOSPHONIQUE-1,1′ ET DU TETRAESTER MÉTHYLIQUE DE L'ACIDE MÉTHANE HYDROXY-1 PHÉNYL-1 DIPHOSPHONIQUE-1,1′

Abstract Structural study using X-Ray crystallography of the two symmetrical diesters 1 and 2 of the titles has been done. Results are discussed on the basis of the environment of phosphorus atoms and on the molecular geometry around the central carbon atom.

[Hydroxy(aryl)methylene]diphosphonic acids, a class of drugs in bone pathology treatments, crystallize as head-to-head dimers.

Two [hydroxy(aryl)methylene]diphosphonic acids have been crystallized as dimers. The first compound, [hydroxy(phenyl)methylene]diphosphonic acid monohydrate, C(7)H(10)O(7)P(2).H(2)O, crystallizes in the non-centrosymmetric space group P2(1), with the two enantiomers related by a non-crystallographic centre of inversion, while the second compound, [hydroxy(4-nitrophenyl)methylene]diphosphonic acid tetrahydrofuran disolvate, C(7)H(9)NO(9)P(2).2C(4)H(8)O, crystallizes in the centrosymmetric space group P2(1)/c and uses the centre of symmetry to form the same dimer.

Angiography contrast agents interact with serine proteinases. The molecular structure of the model system elastase/iohexol.

Pancreatic elastase was co‐crystallised with iohexol, a tri‐iodo benzenic contrast agent used in angiography analyses. The X‐ray analysis of the complex reveals the presence of three molecules of iohexol associated with the proteinase with low occupancy factors. Two iohexol molecules are located in and near the active site of the enzyme and provide a model for explaining the inhibition of the hemostatic system, one of the major and inconvenient side effect associated with these chemicals.

Elecrophilic Substitution of Indoles: Part XI. Lewis Acid Induced Reaction of Skatole with Bezil

The electrophilic substitution of 3-methylindole with benzil in the presence of BF 3 .Et 2 O resulted in a novel heterocyclic system incorporating a stable boron difluoride chelate. The structure was established from spectral analysis ( 1 H-, 13 C-, 11 B-, 19 F-nmr) and X-ray crystallographic analysis