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Featured researches published by A. Núñez.


Veterinary Pathology | 2005

Lymphocyte apoptosis and thrombocytopenia in spleen during classical swine fever: role of macrophages and cytokines.

P.J. Sánchez-Cordón; A. Núñez; F.J. Salguero; M. Pedrera; M. Fernández de Marco; J.C. Gómez-Villamandos

Thirty-two Large White X Landrace pigs, 4 months old, were inoculated with the classical swine fever (CSF) or hog cholera virus strain “Alfort” in order to identify the mechanism responsible for the lymphopenia and thrombocytopenia observed in the spleen during the experimental induction of disease, by immunohistochemical and ultrastructural techniques. Results showed a progressive depletion of splenic lymphoid structures and evidence of platelet aggregation processes. Lymphoid depletion was due to lymphocyte apoptosis, which could not be ascribed to the direct action of the virus on these cells; direct virus action could play only a secondary role in the death of these cells. Absence of severe tissue and endothelial damage, together with moderate procoagulant cytokine levels in the serum, suggest that these pathologies can be ruled out as the cause of platelet aggregation and thrombocytopenia in CSF. Monocyte/macrophages were the main target cells for the CSF virus, and they exhibited phagocytic and secretory activation leading to the synthesis and release of tumor necrosis factor α, which proved to be the chief mediator, followed by IL-6, IL-1α, and C1q complement component. In view of their characteristics, TNF-α and, to a lesser extent, IL-1α and IL-6 appear to be the major cytokines involved in the pathogenesis of lymphocytopenia and thrombocytopenia; a clear spatial and temporal relationship was observed between these two phenomena.


Journal of Comparative Pathology | 2006

Endogenous lipid pneumonia in a dog.

A.I. Raya; M. Fernández-de Marco; A. Núñez; J.C. Afonso; L.E. Cortade; L. Carrasco

Endogenous lipid pneumonia has previously been diagnosed in dogs only once. This report describes a case in a dog with a persistent cough, in which the histological diagnosis was based on the presence of numerous foamy macrophages that filled the alveoli and contained small sudanophilic vacuoles. The appearance of endogenous lipid pneumonia in this animal was accompanied by Dirofilaria immitis infection and chronic bronchitis.


Journal of Comparative Pathology | 2002

Apoptosis of Thymocytes Related to Cytokine Expression in Experimental Classical Swine Fever

P.J. Sánchez-Cordón; S. Romanini; F.J. Salguero; A. Núñez; M.J. Bautista; A. Jover; J.C. Gómez-Villamos


Journal of Veterinary Medicine Series B-infectious Diseases and Veterinary Public Health | 2003

Coinfection by Cryptosporidium parvum and Porcine Circovirus Type 2 in Weaned Pigs

A. Núñez; F. McNeilly; A. Perea; P.J. Sánchez-Cordón; B. Huerta; G. Allan; L. Carrasco


Journal of Comparative Pathology | 2005

Proinflammatory cytokines induce lymphocyte apoptosis in acute African swine fever infection.

F.J. Salguero; P.J. Sánchez-Cordón; A. Núñez; M. Fernández de Marco; J.C. Gómez-Villamandos


Journal of Comparative Pathology | 2002

African Swine Fever: Expression of Interleukin-1 alpha and Tumour Necrosis Factor-alpha by Pulmonary Intravascular Macrophages

L. Carrasco; A. Núñez; F.J. Salguero; F. Díaz San Segundo; P.J. Sánchez-Cordón; J.C. Gómez-Villamandos; M. A. Sierra


Journal of Comparative Pathology | 2005

Evolution of T Lymphocytes and Cytokine Expression in Classical Swine Fever (CSF) Virus Infection

P.J. Sánchez-Cordón; A. Núñez; F.J. Salguero; L. Carrasco; J.C. Gómez-Villamandos


Journal of Comparative Pathology | 2005

Expression of Proinflammatory Cytokines by Hepatic Macrophages in Acute Classical Swine Fever

A. Núñez; J.C. Gómez-Villamandos; P.J. Sánchez-Cordón; M. Fernández de Marco; M. Pedrera; F.J. Salguero; L. Carrasco


Deutsche Tierarztliche Wochenschrift | 2003

African swine fever and classical swine fever: a review of the pathogenesis

J.C. Gómez-Villamandos; L. Carrasco; M.J. Bautista; M. A. Sierra; M. Quezada; J. Hervás; Mdel Chacón; E. Ruiz-Villamor; F.J. Salguero; Pj Sónchez-Cordón; S. Romanini; A. Núñez; T Mekonen; A Méndez; A. Jover


Journal of Comparative Pathology | 2003

Immune complex-associated thrombocytopenic purpura syndrome in sexually mature Göttingen minipigs.

L. Carrasco; L.W. Madsen; F.J. Salguero; A. Núñez; P.J. Sánchez-Cordón; P. Bollen

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P. Bollen

University of Southern Denmark

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