A. Núñez
University of Córdoba (Spain)
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by A. Núñez.
Veterinary Pathology | 2005
P.J. Sánchez-Cordón; A. Núñez; F.J. Salguero; M. Pedrera; M. Fernández de Marco; J.C. Gómez-Villamandos
Thirty-two Large White X Landrace pigs, 4 months old, were inoculated with the classical swine fever (CSF) or hog cholera virus strain “Alfort” in order to identify the mechanism responsible for the lymphopenia and thrombocytopenia observed in the spleen during the experimental induction of disease, by immunohistochemical and ultrastructural techniques. Results showed a progressive depletion of splenic lymphoid structures and evidence of platelet aggregation processes. Lymphoid depletion was due to lymphocyte apoptosis, which could not be ascribed to the direct action of the virus on these cells; direct virus action could play only a secondary role in the death of these cells. Absence of severe tissue and endothelial damage, together with moderate procoagulant cytokine levels in the serum, suggest that these pathologies can be ruled out as the cause of platelet aggregation and thrombocytopenia in CSF. Monocyte/macrophages were the main target cells for the CSF virus, and they exhibited phagocytic and secretory activation leading to the synthesis and release of tumor necrosis factor α, which proved to be the chief mediator, followed by IL-6, IL-1α, and C1q complement component. In view of their characteristics, TNF-α and, to a lesser extent, IL-1α and IL-6 appear to be the major cytokines involved in the pathogenesis of lymphocytopenia and thrombocytopenia; a clear spatial and temporal relationship was observed between these two phenomena.
Journal of Comparative Pathology | 2006
A.I. Raya; M. Fernández-de Marco; A. Núñez; J.C. Afonso; L.E. Cortade; L. Carrasco
Endogenous lipid pneumonia has previously been diagnosed in dogs only once. This report describes a case in a dog with a persistent cough, in which the histological diagnosis was based on the presence of numerous foamy macrophages that filled the alveoli and contained small sudanophilic vacuoles. The appearance of endogenous lipid pneumonia in this animal was accompanied by Dirofilaria immitis infection and chronic bronchitis.
Journal of Comparative Pathology | 2002
P.J. Sánchez-Cordón; S. Romanini; F.J. Salguero; A. Núñez; M.J. Bautista; A. Jover; J.C. Gómez-Villamos
Journal of Veterinary Medicine Series B-infectious Diseases and Veterinary Public Health | 2003
A. Núñez; F. McNeilly; A. Perea; P.J. Sánchez-Cordón; B. Huerta; G. Allan; L. Carrasco
Journal of Comparative Pathology | 2005
F.J. Salguero; P.J. Sánchez-Cordón; A. Núñez; M. Fernández de Marco; J.C. Gómez-Villamandos
Journal of Comparative Pathology | 2002
L. Carrasco; A. Núñez; F.J. Salguero; F. Díaz San Segundo; P.J. Sánchez-Cordón; J.C. Gómez-Villamandos; M. A. Sierra
Journal of Comparative Pathology | 2005
P.J. Sánchez-Cordón; A. Núñez; F.J. Salguero; L. Carrasco; J.C. Gómez-Villamandos
Journal of Comparative Pathology | 2005
A. Núñez; J.C. Gómez-Villamandos; P.J. Sánchez-Cordón; M. Fernández de Marco; M. Pedrera; F.J. Salguero; L. Carrasco
Deutsche Tierarztliche Wochenschrift | 2003
J.C. Gómez-Villamandos; L. Carrasco; M.J. Bautista; M. A. Sierra; M. Quezada; J. Hervás; Mdel Chacón; E. Ruiz-Villamor; F.J. Salguero; Pj Sónchez-Cordón; S. Romanini; A. Núñez; T Mekonen; A Méndez; A. Jover
Journal of Comparative Pathology | 2003
L. Carrasco; L.W. Madsen; F.J. Salguero; A. Núñez; P.J. Sánchez-Cordón; P. Bollen