Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where A. Paci is active.

Publication


Featured researches published by A. Paci.


American Journal of Hypertension | 1998

Endogenous Digitalis-Like Factor and Ouabain Immunoreactivity in Adrenalectomized Patients and Normal Subjects After Acute and Prolonged Salt Loading

Giampaolo Bernini; A. Paci; M Sgro; Angelica Moretti; Antonio Salvetti

The aim of our study was to evaluate whether adrenals are involved in the secretion of endogenous digitalis-like factor(s) with polarity similar to (or less than) that of ouabain (EDLF-1), and whether acute plasma volume expansion is a physiological releasing stimulus for this factor(s) in humans. For this purpose, we measured the concentration of this substance(s) by a human placenta radioreceptor assay (RRA) and by the Du-Pont-NEN ouabain-EIA (immunoreactive ouabain, I-Oua) in plasma C18-extracts of eight normotensives and six patients with bilateral adrenalectomy before and after acute salt loading (2 lt 0.9% NaCl/2 h). The study was repeated after 2 weeks of increased sodium intake (200 mEq/day). Under basal conditions, EDLF-1 by RRA and I-Oua were similar in adrenalectomized patients and in controls and were not significantly modified by saline infusion. After 15 days of high sodium intake, basal plasma EDLF-1 and I-Oua were not significantly different from prediet levels, both in adrenalectomized patients and controls and were likewise unaffected by saline loading. Saline infusion, by contrast, significantly (P < or = .05) suppressed hematocrit and PRA and increased ANP both in controls and in patients, either before or after prolonged high dietary sodium. Plasma aldosterone (ALD) was similarly reduced (P < .001) in controls and, as expected, was undetectable in adrenalectomized patients. Our data indicate that in adrenalectomized patients circulating levels of EDLF-1 and I-Oua are similar to those of controls and that, in both groups, acute saline loading before and after sodium repletion does not influence circulating levels of these compounds. These findings suggest that, at least in humans, adrenals are not the main source of endogenous digitalis-like factor(s) with polarity similar to (or less than) that of ouabain, and that plasma volume expansion may be not a sufficient stimulus for the release of this factor(s).


European Respiratory Journal | 1996

Mitochondria act as a reservoir for the basic amine HIPDM in the lung

Massimo Miniati; A. Paci; Franca Cocci; G. Ciarimboli; Simonetta Monti; Massimo Pistolesi


Hypertension Research | 2000

Endogenous Digitalislike Factors in Obstructive Sleep Apnea

A. Paci; Oreste Marrone; Silvia Lenzi; Concetta Prontera; Giuseppina Nicolini; Gionata Ciabatti; Sergio Ghione; Giovanni Bonsignore


Clinical Chemistry | 1996

Human placenta radioreceptor assay with digoxin and ouabain to detect endogenous digitalis-like factor(s) in human plasma and urine.

A. Paci; G Ciarimboli; P Biver


Clinical Chemistry | 1992

Endogenous digitalis-like factors in human milk.

A. Clerico; A. Paci; M.G. Del Chicca; P. Biver; Ottavio Giampietro


Clinical Chemistry | 1989

Specific binding of cardiac glycoside drugs and endogenous digitalis-like substances to particulate membrane fractions from human placenta.

A. Paci; Franca Cocci; F. Piras; G. Ciarimboli; A. Clerico


Clinical Chemistry | 1996

Commercial enzyme immunoassay reagent pack for ouabain compared with human placenta radioreceptor assay.

A. Paci; A Ledda; G Ciarimboli; P Biver; G P Bernini


Child nephrology and urology | 1990

Endogenous digitalis-like factors : their possible pathophysiological implications with particular regard to the perinatal period

P. Biver; A. Clerico; A. Paci; Silvana Balzan; Antonio Boldrini; Cipolloni C


Clinical Chemistry | 1990

A ligand-receptor binding assay of urinary and circulating endogenous digitalis-like factors

A. Paci; F. Piras; G. Ciarimboli; A. Clerico


Clinical Physiology | 1992

Evaluation of non-respiratory function of the human lung by HIPDM lung scanning

Massimo Miniati; Franca Cocci; A. Paci; L. Giani; Massimo Pistolesi

Collaboration


Dive into the A. Paci's collaboration.

Top Co-Authors

Avatar
Top Co-Authors

Avatar

A. Clerico

Sant'Anna School of Advanced Studies

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Researchain Logo
Decentralizing Knowledge