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Featured researches published by A. Platek.


Laryngoscope | 2016

Smoking cessation is associated with improved survival in oropharynx cancer treated by chemoradiation.

A. Platek; Vijayvel Jayaprakash; Mihai Merzianu; Mary E. Platek; David M. Cohan; Wesley L. Hicks; Sathiya P. Marimuthu; Timothy B. Winslow; Vishal Gupta; Hassan Arshad; Moni Abraham Kuriakose; Shiva Dibaj; James R. Marshall; Mary E. Reid; Graham W. Warren; Anurag K. Singh

The effect of smoking and human papillomavirus (HPV) on overall survival (OS) of oropharyngeal squamous cell carcinoma (OPSCC) patients undergoing concurrent chemotherapy (CCRT) remains unclear.


Journal of Lower Genital Tract Disease | 2016

Impact of Physical Inactivity on Risk of Developing Cancer of the Uterine Cervix: A Case-Control Study.

J.B. Szender; Rikki Cannioto; Nicolas R. Gulati; Kristina Schmitt; Grace Friel; Albina N. Minlikeeva; A. Platek; Emily H. Gower; Ryan Nagy; Edgar Khachatryan; P.C. Mayor; Karin A. Kasza; Shashikant Lele; Kunle Odunsi; Kirsten B. Moysich

Objective In this study, we investigated whether physical inactivity was associated with risk of cervical cancer in women treated at an American cancer hospital. Methods This case-control study included 128 patients with cervical cancer and 512 controls matched on age. Controls were women suspected of having but not ultimately diagnosed with a neoplasm. Physical inactivity was defined in accordance with the 2008 Physical Activity Guidelines for Americans. Thus, participants reporting, on average, no moderate or vigorous recreational physical activity were classified as inactive. Unconditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Results Compared with noncancer controls, those with cervical cancer had significantly increased odds of reporting abstinence from recreational physical activity (OR, 2.43; 95% CI, 1.56–3.80). No association was noted between occupational-related physical inactivity and cervical cancer (OR, 0.88; 95% CI, 0.58–1.36). Conclusions Our findings suggest that abstinence from regular recreational physical activity is associated with increased odds of cervical cancer. To our knowledge, this is the first US-based study examining these associations. Given the 2008 Physical Activity Guidelines for Americans, this study has identified yet another potential public health benefit to regular physical activity. Further investigation is needed using a larger sample and prospectively collected data to characterize dose of activity to mitigate risk and the optimal window of susceptibility.


Oral Oncology | 2018

Routine surveillance scanning in HNSCC: Lung screening CT scans have value but head and neck scans do not

Austin J. Iovoli; A. Platek; Luke Degraaff; Chong Wang; William D. Duncan; Kimberly E. Wooten; Hassan Arshad; Vishal Gupta; Moni Abraham Kuriakose; Wesley L. Hicks; Mary E. Platek; Anurag K. Singh

OBJECTIVES To examine the utility of computed tomography (CT) imaging during routine surveillance for the detection of recurrent head and neck squamous cell carcinoma (HNSCC). MATERIALS/METHODS Clinical characteristics of HNSCC patients treated between 2008 and 2017 with radiation therapy or concurrent chemoradiation were abstracted from medical records. In patients who achieved a complete response to treatment by positron emission tomography scan, surveillance CT scans were conducted to the maxillofacial area, neck, and chest every 3 months in year 1, every 6 months in year 2, and every 12 months in years 3 and beyond. RESULTS Within the entire cohort (n = 534), complete response was achieved in 446 patients (83.5%); of these, 84 (15.7%) patients had a recurrence. Among the 84 patients with disease recurrence, 25 (30%) patients remained alive, of which 15 (18%) underwent successful salvage treatment and became free of disease. Lung screening CT scans detected failure in 8 of these successfully salvaged patients. Among the 8 patients successfully salvaged for locoregional recurrence, 3 failures were asymptomatic at onset and detected by laryngoscope or dental exam. The remaining 5 failures were symptomatic and detected upon work up prompted by symptoms. Maxillofacial and neck surveillance CT imaging failed to detect any successfully salvaged patients. CONCLUSIONS Routine surveillance for HNSCC patients with lung CT imaging had value but routine head and neck CT scans failed to identify any successfully salvaged patients. Given this finding, routine CT imaging surveillance in HNSCC patients should be restricted to annual lung screening with low-dose chest CT.


Oncotarget | 2017

Combined surgery and radiation improves survival of tonsil squamous cell cancers

Anurag K. Singh; Christina Mimikos; Adrienne Groman; Shiva Dibaj; A. Platek; David M. Cohan; Wesley L. Hicks; Vishal Gupta; Hassan Arshad; Moni Abraham Kuriakose; Graham W. Warren; Mary E. Platek

Objective The study evaluated the addition of surgery (S) to radiation (RT) on survival of squamous cell carcinomas (SCC) of tonsillar-fossa (TF) in a modern cohort with similar epidemiology and treatment as current patients. Study Design Retrospective analysis utilizing Surveillance, Epidemiology, and End Results (SEER) Program data. Results For all stages combined TF patients who received S+RT had superior OS (p < 0.01) and DSS (p < 0.01). For each stage OS and DSS was superior for S+RT (p < 0.05). In multivariate analysis, HRs for OS were statistically significantly higher for TF patients (stage 2, 3, and 4) receiving RT alone (p < 0.001). Materials and Methods TF SCC patients treated with either S+RT or RT alone between 2004 and 2011 were examined (n = 6,476). Primary outcome measures included overall survival (OS) and disease specific survival (DSS). Cox proportional hazard ratios (HR) were estimated for patients treated with S+RT compared to RT alone. Conclusions OS and DSS were superior for all stages combined and for stages 2, 3, and 4 in TF patients who received S+RT compared to RT alone.


Laryngoscope | 2017

Subsite variation in survival of oropharyngeal squamous cell carcinomas 2004 to 2011.

Mary E. Platek; Vijayvel Jayaprakash; Vishal Gupta; David M. Cohan; Wesley L. Hicks; Timothy B. Winslow; A. Platek; Adrienne Groman; Shiva Dibaj; Hassan Arshad; Moni Abraham Kuriakose; Graham W. Warren; Anurag K. Singh

To evaluate subsite‐specific differences in survival between squamous cell carcinomas of the base of tongue and tonsillar fossa in a modern cohort likely to have been treated with intensity‐modulated radiation therapy, chemotherapy for stage III and IV, and have had a high incidence of human papillomavirus–associated tumors.


International Journal of Radiation Oncology Biology Physics | 2018

Bilateral Elective Nodal Radiation Increases Narcotic Requirement But Not Patient-Reported Pain During Head and Neck Cancer Radioation Therapy

G.M. Hermann; A.J. Iovoli; A. Platek; L.H. DeGraaff; A. Ostrowski; A. Miller; A.K. Singh


International Journal of Radiation Oncology Biology Physics | 2018

Prophylactic Gabapentin Combined with Methadone Improves Overall Health in Patients Undergoing Chemoradiation for Head and Neck Cancer While Reducing Use of Opioids with High Abuse Potential: Early Results of a Prospective Randomized Trial

G.M. Hermann; A.J. Iovoli; A. Platek; L.H. DeGraaff; A. Ostrowski; A.K. Singh


International Journal of Radiation Oncology Biology Physics | 2018

In the Era of PET Scans, Is Unilateral Radiation Therapy Enough to Treat Squamous Cell Carcinomas of the Head and Neck From an Unknown Primary?

A. Platek; M.D. Mix; V. Chaudhri; Mary E. Platek; W.L. Hicks; M.A. LaCombe; K.E. Wooten; L.H. DeGraaff; A.J. Iovoli; Vishal Gupta; A. Hassan; Moni Abraham Kuriakose; S.S. Hahn; Anurag K. Singh


International Journal of Radiation Oncology Biology Physics | 2018

The Effect of Delay Between Diagnosis and Initiation of Treatment on Outcomes in Patients With Head and Neck Squamous Cell Carcinoma

L.H. DeGraaff; A. Platek; A.J. Iovoli; Mary E. Platek; K.E. Wooten; A. Hassan; Vishal Gupta; Wesley L. Hicks; A.K. Singh


International Journal of Radiation Oncology Biology Physics | 2018

Routine Surveillance Scanning in Patients With Squamous Cell Carcinoma of the Head and Neck: Lung Screening CT Scans Have Value but Head and Neck Scans Do Not Identify Patients Who Achieve Long-Term Disease Control

A.J. Iovoli; A. Platek; L.H. DeGraaff; Mary E. Platek; A. Hassan; Vishal Gupta; K.E. Wooten; Wesley L. Hicks; A.K. Singh

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Mary E. Platek

Roswell Park Cancer Institute

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Vishal Gupta

Roswell Park Cancer Institute

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Wesley L. Hicks

Roswell Park Cancer Institute

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A.K. Singh

Roswell Park Cancer Institute

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Hassan Arshad

Roswell Park Cancer Institute

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Anurag K. Singh

Roswell Park Cancer Institute

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David M. Cohan

Roswell Park Cancer Institute

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Graham W. Warren

Medical University of South Carolina

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Shiva Dibaj

Roswell Park Cancer Institute

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