A Rizvi

Acute Graft Dysfunction Due to Pyelonephritis: Value and Safety of Graft Biopsy

Urinary tract infections are the most common infection following renal transplant. Renal transplant recipient have 28% to more than 90% incidence of urinary tract infection occurring after hospital discharge. Risk factors of development of UTI include indwelling catheter, urinary bladder dysfunction especially in diabetic patients, anatomical abnormality, renal insufficiency, nutritional deficiency, and possibly rejection and immunosuppression. It can lead to graft dysfunction and may induce graft loss in severe pyelonephritis. Morbidity associated with urinary tract infection happens to be related to the timing of episode during post transplant period. Infection occurring during early transplant period is generally more serious. It can cause a graft dysfunction and even graft loss. While infection developing 3–6 months after transplantation are more benign and rarely associated with bacteremia. The role of renal allograft biopsy in patients with suspected pyelonephritis and graft dysfunction is not well defined. This study tries to analyze its value and safety in a living related transplant program.

Donor selection in living donors: prospects and problems

THE ESTIMATED prevalence of end-stage renal disease (ESRD) in Pakistan is 100 per million population. The cost of dialysis is approximately US

High dose steroid regime: a tool for reducing organ rejection

5000 to 6000 per annum. As the gross national product is US

Efficacy of Isoniazid Prophylaxis in Renal Allograft Recipients

430 in the country, the majority of patients with ESRD cannot afford dialysis. The public sector does not offer free dialysis facilities. Cadaver organ donation is not permitted by the legislature and is not fully accepted by society. Live donation thus remains the only choice and most feasible mode of renal support for these subjects.

Developing world perspective of posttransplant tuberculosis: morbidity, mortality, and cost implications.

IMMUNOSUPPRESSION is an important aspect of organ transplantation (Tx). In the last three decades many new drugs have been introduced. The three main categories are anti–inflammatory drugs, cytotoxics, and fungal and bacterial derivatives. Despite the change in protocol and the multiple side effects, steroids still are the gold standard and play an important role in graft protection. This retrospective study was conducted on two groups of transplanted patients receiving two different dose regimes of steroids to assess the frequency and type of complications and the frequency of acute rejection episodes.