A. Sagisaka

Application of laser-accelerated protons to the demonstration of DNA double-strand breaks in human cancer cells

We report the demonstrated irradiation effect of laser-accelerated protons on human cancer cells. In vitro (living) A549 cells are irradiated with quasimonoenergetic proton bunches of 0.8–2.4 MeV with a single bunch duration of 15 ns. Irradiation with the proton dose of 20 Gy results in a distinct formation of γ-H2AX foci as an indicator of DNA double-strand breaks generated in the cancer cells. This is a pioneering result that points to future investigations of the radiobiological effects of laser-driven ion beams. Unique high-current and short-bunch features make laser-driven proton bunches an excitation source for time-resolved determination of radical yields.

Demonstration of laser-frequency upshift by electron-density modulations in a plasma wakefield.

Since the advent of chirped pulse amplification1 the peak power of lasers has grown dramatically and opened the new branch of high field science, delivering the focused irradiance, electric fields of which drive electrons into the relativistic regime. In a plasma wake wave generated by such a laser, modulations of the electron density naturally and robustly take the shape of paraboloidal dense shells, separated by evacuated regions, moving almost at the speed of light. When we inject another counter-propagating laser pulse, it is partially reflected from the shells, acting as relativistic flying (semi-transparent) mirrors, producing an extremely time-compressed frequency-multiplied pulse which may be focused tightly to the diffraction limit. This is as if the counterstreaming laser pulse bounces off a relativistically swung tennis racket, turning the ball of the laser photons into another ball of coherent X-ray photons but with a form extremely relativistically compressed to attosecond and zeptosecond levels. Here we report the first demonstration of the frequency multiplication detected from the reflection of a weak laser pulse in the region of the wake wave generated by the driver pulse in helium plasma. This leads to the possibility of very strong pulse compression and extreme coherent light intensification. This Relativistic Tennis with photon beams is demonstrated leading to the possibility toward reaching enormous electromagnetic field intensification and finally approaching the Schwinger field, toward which the vacuum nonlinearly warps and eventually breaks, producing electron-positron pairs.

Proton acceleration to 40 MeV using a high intensity, high contrast optical parametric chirped-pulse amplification/Ti:sapphire hybrid laser system.

Using a high-contrast (10(10):1) and high-intensity (10(21) W/cm(2)) laser pulse with the duration of 40 fs from an optical parametric chirped-pulse amplification/Ti:sapphire laser, a 40 MeV proton bunch is obtained, which is a record for laser pulse with energy less than 10 J. The efficiency for generation of protons with kinetic energy above 15 MeV is 0.1%.

Laser prepulse dependency of proton-energy distributions in ultraintense laser-foil interactions with an online time-of-flight technique

Fast protons are observed by a newly developed online time-of-flight spectrometer, which provides shot-to-shot proton-energy distributions immediately after the irradiation of a laser pulse having an intensity of ∼1018W∕cm2 onto a 5-μm-thick copper foil. The maximum proton energy is found to increase when the intensity of a fs prepulse arriving 9ns before the main pulse increases from 1014 to 1015W∕cm2. Interferometric measurement indicates that the preformed-plasma expansion at the front surface is smaller than 15μm, which corresponds to the spatial resolution of the diagnostics. This sharp gradient of the plasma has the beneficial effect of increasing the absorption efficiency of the main-pulse energy, resulting in the increase in the proton energy. This is supported by the result that the x-ray intensity from the laser plasma clearly increases with the prepulse intensity.

Measurement of relative biological effectiveness of protons in human cancer cells using a laser-driven quasimonoenergetic proton beamline

Human cancer cells are irradiated by laser-driven quasimonoenergetic protons. Laser pulse intensities at the 5×1019 W/cm2 level provide the source and acceleration field for protons that are subsequently transported by four energy-selective dipole magnets. The transport line delivers 2.25 MeV protons with an energy spread of 0.66 MeV and a bunch duration of 20 ns. The survival fraction of in vitro cells from a human salivary gland tumor is measured with a colony formation assay following proton irradiation at dose levels of up to 8 Gy, for which the single bunch dose rate is 1×107 Gy/s and the effective dose rate is 0.2 Gy/s for 1 Hz repetition of irradiation. Relative biological effectiveness at the 10% survival fraction is measured to be 1.20±0.11 using protons with a linear energy transfer of 17.1 keV/μm.

Frequency multiplication of light back-reflected from a relativistic wake wave

A method of coherent high-frequency electromagnetic radiation generation, proposed by Bulanov, Esirkepov, and Tajima [Phys. Rev. Lett. 91, 085001 (2003)], is experimentally demonstrated. This method is based on the radiation frequency multiplication during reflection at a mirror flying with relativistic velocity. The relativistic mirror is formed by the electron density modulations in a strongly nonlinear wake wave, excited in an underdense plasma in the wake behind an ultrashort laser pulse. In our experiments, the reflection of a countercrossing laser pulse from the wake wave is observed. The detected frequency multiplication factor is in the range from 55 to 114, corresponding to a reflected radiation wavelength from 7 to 15nm. This may open a way towards tunable high-intensity sources of ultrashort coherent electromagnetic pulses in the extreme ultraviolet and x-ray spectral regions. Parameters of the reflecting wake wave can be determined using the reflected radiation as a probe.

Real-Time Optimization of Proton Production by Intense Short-Pulse Laser with Time-of-Flight Measurement

A scheme of the real-time optimization of proton production by an intense short-pulse laser interacting with a foil target was developed using a time-of-flight measurement with a plastic scintillator. Owing to special treatments, the detection of protons using a scintillation counter has become possible under heavy backgrounds such as laser light itself, laser-generated hard X-ray, self-emission light, and electrons from the laser-produced plasma. With such a real-time measurement of protons, the energy spectrum of protons could be obtained shot by shot, and the experimental conditions for optimal proton production could be determined very efficiently.

Attosecond pulse generation in the relativistic regime of the laser-foil interaction: The sliding mirror model

Theory of the attosecond pulse generation during the interaction of a short relativistic-irradiance laser pulse with a thin overdense plasma slab is developed. The nonlinear electric current caused by the electron motion at relativistic velocity generates the high-order harmonics of the incident radiation. These harmonics are phase locked and can produce pulses with attosecond duration after spectral filtering. Conditions for the most efficient generation of single-attosecond pulses are discussed. A very efficient regime of attosecond pulse train generation without spectral filtering is proposed. The results are verified by the particle-in-cell simulations.

Focusing and spectral enhancement of a repetition-rated, laser-driven, divergent multi-MeV proton beam using permanent quadrupole magnets

A pair of conventional permanent magnet quadrupoles is used to focus a 2.4 MeV laser-driven proton beam at a 1 Hz repetition rate. The magnetic field strengths are 55 and 60 T/m for the first and second quadrupoles, respectively. The proton beam is focused to a spot with a size of less than ∼3×8 mm2 at a distance of 650 mm from the source. This result is in good agreement with the Monte Carlo particle trajectory simulation.

Efficient production of a collimated MeV proton beam from a polyimide target driven by an intense femtosecond laser pulse

High-flux energetic protons whose maximum energies are up to 4MeV are generated by an intense femtosecond titanium:sapphire laser pulse interacting with 7.5, 12.5, and 25μm thick polyimide tape targets. Laser pulse with an energy of 1.7J and with a duration of 34fs is focused with an f/3.4 parabolic mirror giving an intensity of 3×1019Wcm−2. The main pulse to amplified spontaneous emission (ASE) intensity contrast ratio is 2.5×107. The conversion efficiency from the laser energy into the proton kinetic energies is achieved to be ∼3%, which is comparable to or even higher than those achieved in the previous works; using nanometer-thick targets, in combination with the short-pulse lasers that have almost the same pulse width and the intensity but different main pulse to ASE intensity contrast of ∼1010 [Neely et al., Appl. Phys. Lett. 89, 021502 (2006)], in which the authors claim that the main mechanism is target normal sheath acceleration; or using the 7.5μm thick polyimide target, in combination with the ...