A. Tuffanelli

Dual-energy tissue cancellation in mammography with quasi-monochromatic x-rays

Dual-energy radiography has not evolved into a routine clinical examination yet due to intrinsic limitations of both dual-kVp imaging and single-exposure imaging with conventional x-ray sources. The recent introduction of novel quasi-monochromatic x-ray sources and detectors could lead to interesting improvements, especially in mammography where the complex structure of healthy tissues often masks the detectability of lesions. A dual-energy radiography technique based on a tissue cancellation algorithm has been developed for mammography, with the aim of maximizing the low intrinsic contrast of pathologic tissues while being able to minimize or cancel the contrast between glandular and fat tissues. Several images of a plastic test object containing various tissue equivalent inserts were acquired in the energy range 17-36 keV using a quasi-monochromatic x-ray source and a scintillator-coated CCD detector. Images acquired at high and low energies were nonlinearly combined to generate two energy-independent basis images. Suitable linear combinations of these two basis images result in the elimination of the contrast of a given material with respect to another. This makes it possible to selectively cancel certain details in the processed image.

A prototype of a quasi-monochromatic system for mammography applications

Improvement in image contrast and dose reduction, in mammographic x-ray imaging, can be achieved using narrow energy band x-ray beams in the 16-24 keV range. As part of an Italian Government funded project, a quasi-monochromatic system for mammography applications has been developed. The system is based on a tunable narrow energy band x-ray source operating in the 16-24 keV energy range. The bremsstrahlung beam is monochromatized via Bragg diffraction by a highly oriented pyrolytic graphite mosaic crystal (HOPG). The scanning system provides a large field (18 x 24 cm2) of quasi-monochromatic x-rays with energy resolution ranging from 10% at 18 keV to 17.2% at 24 keV. The system has been characterized in terms of fluence rate and energy resolution. An x-ray tube developed ad hoc allows us to acquire images in a reasonable time to minimize the motion blur. A qualitative analysis has been performed in order to know if the prototype system performances are far from a clinical application, by evaluating the spatial resolution, the field uniformity and the image quality as a function of the quasi-monochromatic beam energy. Dose evaluation has been performed as a function of the energy and compared to a conventional system for mammography. The quasi-monochromatic prototype system can produce comparable image quality at half the dose.

K-edge digital subtraction imaging based on a dichromatic and compact x-ray source

This work proposes a compact dichromatic imaging system for the application of the K-edge digital subtraction technique based on a conventional x-ray tube and a monochromator system. A quasi-monochromatic x-ray beam at the energy of iodine K-edge is produced by Bragg diffraction on a mosaic crystal. Two thin adjacent beams with energies that bracket the K-edge discontinuity are obtained from the diffracted beam by means of a proper collimation system. They are then detected using an array of Si detectors. A home-made phantom is used to study the image quality as a function of iodine concentration. Signal and signal-to-noise ratio analysis has also been performed. The results are compared with theoretical expectations.

MTF evaluation of a phosphor-coated CCD for x-ray imaging

A novel digital x-ray detector has been assembled. The imaging system is based on a phosphor-coated charge-coupled device (CCD) obtained by direct deposition of a gadolinium oxysulphide scintillator onto the detector surface. The modulation transfer function has been measured along the two directions of the digital coordinates with the narrow slit technique. A resolution limit of about 20 line pairs per mm has been obtained for both directions. The high spatial resolution currently demanded in mammography can be achieved with this imaging system.

Contrast cancellation technique applied to digital x-ray imaging using silicon strip detectors.

Dual-energy mammographic imaging experimental tests have been performed using a compact dichromatic imaging system based on a conventional x-ray tube, a mosaic crystal, and a 384-strip silicon detector equipped with full-custom electronics with single photon counting capability. For simulating mammal tissue, a three-component phantom, made of Plexiglass, polyethylene, and water, has been used. Images have been collected with three different pairs of x-ray energies: 16-32 keV, 18-36 keV, and 20-40 keV. A Monte Carlo simulation of the experiment has also been carried out using the MCNP-4C transport code. The Alvarez-Macovski algorithm has been applied both to experimental and simulated data to remove the contrast between two of the phantom materials so as to enhance the visibility of the third one.

Quasi-monochromatic x-rays for diagnostic radiology

Monochromatic x-ray beams are desirable in various fields of diagnostic radiology; in fact a reduction of the dose and an enhancement of the contrast could be achieved. In this work two different methods to monochromatize x-ray beams produced by conventional tubes have been compared. In the first one the beam is obtained via Bragg diffraction on mosaic crystal and in the second one by attenuating the polychromatic beam with aluminium filters. We have simulated quasi-monochromatic x-ray spectra by setting suitable values of Braggs angle to obtain beams tuned to 20, 30, 40 and 50 keV with the SHADOW code, an x-ray tracing program designed to study the propagation and the interaction of a photon beam through an optical system. We have validated such a program by comparing some calculated data with measurements carried out on an experimental apparatus. Attenuated polychromatic x-ray spectra have been simulated by setting appropriate values of aluminium filters and potential with the SPECTRUM PROCESSOR, the software version of the Catalogue of Spectral Data for Diagnostic X-Rays, which provides radiographic x-ray spectra that can be attenuated with several material filters. The relation between the energy resolution and the flux as a function of the mean energy has been investigated and results have been compared. Results show that quasi-monochromatic x-ray beams produced via Bragg diffraction exhibit, for a given mean energy and energy resolution, a higher total flux compared to attenuated spectra.

Spatial resolution measurements in quasimonochromatic x rays with mosaic crystals for mammography application

A novel x-ray source for mammography application is being investigated. Quasimonochromatic x rays have been produced via Bragg diffraction with a W-anode x-ray tube and a graphite mosaic crystal array. The system provides 18 keV x rays with an energy resolution deltaE/E approximately equals 0.12. A thorough analysis of the spatial resolution of the system has been performed in order to understand and quantify the effect of the introduction of an active optical element such as a mosaic crystal in the x-ray path. The focal spot of the source and its emission properties have been studied by using the slit camera method. Experiments have shown that the introduction of a mosaic crystal in the optical path modifies the resolution properties of the Bragg diffraction-based radiography system. Along the direction perpendicular to the diffraction plane the resolution properties of the imaging system mainly depend on the x-ray tube focal spot size and position. Along the diffraction plane the focal spot size depends on mosaic characteristics and on the geometrical setup. Hence, it could be modified by setting the appropriate experimental conditions.

Focusing properties of mosaic crystals

X-ray instruments with mosaic crystals are proposed and used in many applications in synchrotron radiation, medical physics and astrophysics. These crystals present a parafocusing of the x-ray beam in the diffraction plane, which is thoroughly analyzed in this paper. We studied the evolution of the cross- section of the diffracted beam, using several samples of Highly Oriented Pyrolythic Graphite crystals coming from different suppliers. The experiment has been performed at the European Synchrotron Radiation Facility (beamline BM5). The results clearly show a parafocusing effect in the 1:1 magnification ratio along the diffraction plane and a defocusing effect along the perpendicular plane. The secondary extinction coefficient is also measured.

Evaluation of a digital X-ray detector based on a phosphor-coated CCD for mammography

Abstract The imaging performance of a phosphor-coated CCD system for mammography application is evaluated. The coated CCD is obtained by direct deposition of a Gd2O2S:Eu powder onto a detector surface. Modulation transfer function, noise power spectrum, and detective quantum efficiency are measured. Their dependence on the input beam X-ray energy is discussed. Images of a test phantom for mammography are compared with those obtained with a screen-film combination.

Bragg-diffraction-based quasi-monochromatic source for mammography using mosaic crystals

The existence of an optimal energy range for mammography has been demonstrated by several authors. Improvement in image contrast and reduction of patient dose can be achieved using narrow energy band X ray beams in the 16 - 24 keV range. Quasi-monochromatic X rays in the mammographic energy range have been produced via Bragg diffraction by making use of a conventional W-anode, Be-window X ray tube and a monochromator optical system based on a set of mosaic crystals. The mosaic crystals are high oriented pyrolytic graphite (002) which provide an interesting choice for monochromators because of their high integrated reflectivity compared to perfect crystals. The monochromator optical system consists of an array of ten crystals (2.8 X 6.0 cm2 of size) which are assembled so as to produce in the image plane an irradiation field obtained with adjacent reflected beams. A scanning technique of the optical system has been applied in order to remove the spatial non- uniformities of the entire irradiation field. The source has been characterized in terms of beam size and monochromaticity, photon flux and exposure rate, field uniformity, capability in low contrast detection, dose reduction, and spatial resolution properties. The system provides a large field (10.5 X 12.0 cm2) of quasi- monochromatic X rays ((Delta) E/E equals 12%) at the energy of 18 keV. The spatial resolution capabilities of the sources are affected by the introduction of an active optical element such as a mosaic crystal monochromator. They may be optimized by choosing the proper irradiation geometry. The mean glandular dose delivered to the standard breast by the quasi-monochromatic source is about a half of those delivered by the conventional mammography units.