A. V. Rama Rao

Enantioselective catalytic reductions of ketones with new four membered oxazaborolidines: Application to (S)-tetramisole

Enantioselective catalytic reduction of ketones with both the enantiomers of new four membered oxazaborolidines is described.

Studies directed towards the synthesis of immunosuppressive agent FK-506 : synthesis of the entire bottom-half

An efficient approach has been developed to construct the entire TOP-HALF of FK-506 involving Grignard reaction of a C-29 bromide with a C-27 methylketo fragment.

3-Butene-1,2-diol: An attractive precursor for the synthesis of enantiomerically pure organic compounds

3-Butene-1,2-diol obtained by the isomerization of cis-butene-1,4-diol has been transformed into several chiral building blocks.

Enantioselective reductions of ketones with oxazaborolidines derived from (R and (S-α-α-diphenyl-2-piperdine methanol

Abstract Oxazaborolidines obtained from ( R and ( S -α,α-diphenyl-2-piperidine methanol have been used as catalysts in the enantioselective reductions of ketones with borane,

Asymmetric synthesis of C-19 to C-27 fragment of rifamycin-S

A highly stereoselective asymmetric synthesis of C-19 to C-27 fragment of Rifamycin-S consisting of 7 contiguous asymmetric centres is described involving Ipc2BH as the chiral hydroborating reagent.

Synthesis of (R)-1-benzyloxy-3-buten-2-ol- a potential chiral synthon from L-(+)-tartaric acid: its applications in natural product syntheses

Abstract A practical synthesis of (R)-3-butene-1,2-diol derivatives from (R,R)-tartaric acid and their applications for the syntheses of (R)-ethyl-5-benzoyloxy-5-formyl pentanoate (2), a useful synthon for the preparation of arachidonic acid metabolites and (R)-γ-caprolactone (3), a pheromone of Trogoderma species, are described.

The first synthesis of C-terminal biphenyl moiety of vancomycin

Abstract A successful Palladium catalysed intramolecular coupling of phenyl rings corresponding to amino acids (R)-4-hydroxyphenylglycine ( 5 ) and (S)-3,5-dihydroxyphenylglycine ( 7 ) of vancomycin is achieved.

Studies directed towards the total synthesis of aranorosin

Abstract Protocols that led to the construction of cyclohexanone bisoxirane as a part of l-oxaspiro[4,5]decane moiety present in aranorosin, are described.

Studies directed towards the synthesis of rapamycin : stereoselective synthesis of C-1 to C-15 segment

Stereoselective synthesis of a suitably functionalized C-1 to C-15 segment of rapamycin is described.

A formal synthesis of a novel immunosuppressant ISP-1 : Stereocontrolled Pd(O) catalysed cis-hydroxyamination of carbohydrate derived vinyl epoxide

Abstract Described herein are the results leading to the synthesis of ISP-1 containing an unusal α, α-disubstituted amino acid and whose immunosuppressive activity only has recently been discovered.