Aadil Chagla

Retrospective analysis of peripheral nerve sheath tumors of the second cervical nerve root in 60 surgically treated patients.

OBJECT This study is a retrospective analysis of 60 surgically treated patients with 64 peripheral nerve sheath tumors (PNSTs) at the second cervical (C-2) nerve root. The anatomical subtleties of these tumors and their implications for surgical strategy when compared with other spinal PNSTs and other tumors in the foramen magnum region are reviewed. METHODS Sixty patients with C-2 PNSTs treated surgically in the Department of Neurosurgery at King Edward VII Memorial Hospital and Seth Gordhandas Sunderdas Medical College between 1992 and 2006 were studied. All patients underwent magnetic resonance imaging. Tumors were divided into 3 groups depending on their anatomical location identified during surgery. Those tumors located within or extending into the spinal dural tube were called Type A, those located within the dural tube of the C-2 ganglion were labeled as Type B, and tumors extending laterally into the paraspinal region were labeled as Type C. Follow-up durations ranged from 6 months to 15 years (mean 64 months). RESULTS There were 38 male and 22 female patients in the study, who ranged in age from 6 to 62 years (mean 28 years). Nine patients had clinical features indicative of neurofibromatosis (NF). The mean duration of symptoms at the time of presentation was 27 months (range 4 days-5 years). Two patients had no specific symptoms related to the C-2 PNST, 6 patients had only local symptoms such as neck pain or stiffness, and 52 patients had symptoms of varying degrees of myelopathy. There were 5 solely Type A tumors, 7 Type A + B tumors, 31 Type B tumors, and 21 Type B + C tumors. All Type A, A + B, and B tumors were totally resected. Seven of 21 Type B + C tumors were partially resected, and the remainder were completely resected. All patients postoperatively reported varying improvement in their preoperative symptoms. Except for patients with NF who were disabled by other tumors, the rest of the patients resumed their normal life style. There have been no cases of symptomatic tumor recurrence. CONCLUSIONS The majority of PNSTs located at the C-2 level in these patients probably arose from the large C-2 ganglion and are limited within the dural confines or are interdural in location. In contrast to other spinal PNSTs, the location of C-2 PNSTs is in most cases posterior to the lateral mass of the atlas and axis and the atlantoaxial joint and is exposed to the posterior without any bone cover. Radical tumor resection is safe, resolution of clinical symptoms is rapid, and recurrence rates are extremely low. In a selected number of cases, bone work for tumor exposure and resection can be entirely avoided.

Endodermal cyst anterior and anterolateral to the brainstem. A report of an experience with seven cases

We report our experience with seven cases of endodermal cysts located anterior and anterolateral to the brainstem. The ages of the patients ranged from 10 to 35 years. There were three males and four females. The cysts had characteristic imaging features, and contained fluid having a ‘greenish-yellow pus-like’ hue and consistency varied from thin watery fluid to colloid gel like material. The capsule of the tumour was relatively thin. A radical resection of the cyst contents was done in all cases. Because of the thin nature of capsule, wide extensions and intimate relationship with critical nerves and vessels, complete resection of the cyst wall was possible only in one case, whilst in others the wall was partially resected. All patients showed a rapid symptomatic and neurological recovery. During the average follow-up period of 53 months, there has been no recurrence in the cyst and all patients are leading normal lives. In this presentation, the clinical and radiological features and surgical management of endodermal cysts are discussed and the relevant literature is briefly reviewed. It appears that evacuation of the cyst contents and partial resection of the cyst wall could be a safe treatment option in these cases.

Seeding metastases of a benign intraventricular meningioma along the surgical track

Seeding metastases of a benign intraventricular meningioma along the surgical track is rare. We report a patient with a benign fibroblastic intraventricular meningioma that had spread along the path of previous surgery; the recurrences as well as the primary tumor were benign.

A massive cervicomedullary intramedullary spinal cord lipoma.

We present a large cervicomedullary intramedullary lipoma in a 17-year-old boy, who presented with spastic quadriparesis and exaggerated reflexes. MRI revealed an intramedullary lipoma extending from the craniovertebral junction to the sixth cervical vertebra. There was no spinal dysraphism. Subtotal excision with primary dural closure was performed, which produced an improvement in the patients condition. The technique we used is discussed.

Complete recovery of visual loss following surgical treatment of mucopyocele of the anterior clinoid process.

A mucocele is a collection of mucus, which is lined by the mucus-secreting epithelium of a paranasal sinus. Paranasal sinus mucoceles occur as a result of inflammation, tumor, trauma or surgical manipulation. The anterior clinoid process may be pneumatized by an extension of the sphenoid paranasal sinus air space during normal development. Mucocele of the anterior clinoid process is rare. We report a patient with mucopyocele of the anterior clinoid process that resulted in rapid monocular visual loss. The left optic canal was exposed extradurally via a supraorbital craniotomy and the mucopyocele was totally excised. The optic canal was decompressed by drilling the superior, lateral and medial rims, to achieve circumferential decompression of the optic nerve. The patients vision improved postoperatively.

Giant ventral midline schwannoma of cervical spine : agonies and nuances.

Pure ventral midline giant schwannoma is an extremely rare entity. Spinal intradural extramedullary schwannomas commonly occur posterolateral or anterolateral to the spinal cord. A case of a pure midline ventrally situated giant pan cervical extramedullary schwannoma in an 18-year-old male patient with compressive myelopathy and sphincter involvement is presented. Spinal MR imaging showed a midline ventrally situated extramedullary tumor with severe spinal cord compression extending from clivus to C7 vertebra. It was resected through a posterolateral approach. Histology was consistent with a schwannoma. Post operative MR imaging showed no evidence of the tumor. The radiological features, pathogenesis and surgical strategies in management of these difficult tumors are discussed and the relevant literature is briefly reviewed.

Polytetrafluoroethylene sponge syringosubarachnoid shunt.

Syringomyelia is condition in which a cyst or cavity forms inside the spinal cavity. Its management always remains a difficult. A variety of surgical techniques have been used in management of syringomyelia. Syringosubarachnoid shunt remains an effective method in management of syringomyelia. Shunt tube obstruction remains an important complication of shunt procedure. We describe a novel technique of use of polytetrafluoroethylene sponge shunt for syringosubarachnoid shunt in patient with large syrinx and Chiari 1 malformation. Polytetrafluoroethylene sponge is a non irritant material with multiple porosities that is less susceptible to blockages or kinking. It could provide a good alternative technique in syringosubarachnoid shunting.

Cystic chordoma of cavernous sinus

Chordomas are the tumors commonly involving base of skull which are predominantly solid in consistency. A cystic chordoma of the cavernous sinus is an extremely rare entity and has never been reported. We report a 26-year-old male presenting with gradually progressive right-sided sixth nerve palsy and headache. Computed tomography and magnetic resonance imaging of the brain showed a cystic lesion in the right cavernous sinus. The patient was successfully treated using a transnasal endoscopic transsphenoidal approach. Histopathological examination of the lesion revealed chordoma. Our case is the first report of such a condition. Chordoma should be considered in the differential diagnosis of cystic lesions in the parasellar location. We briefly review the radiology, the pathology and management dilemmas of such lesions.

Intraconal optic sheath schwannoma: report of two cases

Abstract Optic sheath schwannoma is extremely rare. We discuss two cases of intraorbital intraconal optic sheath schwannoma. Vision significantly improved in both patients following the surgery. We have briefly described the surgical technique & discussed the relevant literature