Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Aamir Ahmed is active.

Publication


Featured researches published by Aamir Ahmed.


Molecular Membrane Biology | 1994

Subcellular distribution and immunocytochemical localization of Na,K-ATPase subunit isoforms in human skeletal muscle.

Harinder S. Hundal; Diane L. Maxwell; Aamir Ahmed; Froogh Darakhshant; Yasuhide Mitsumotoi; Amira Klip

The expression of Na,K-ATPase isoforms was investigated in human skeletal muscle membranes isolated by subcellular fractionation. The alpha 1, alpha 2, alpha 3 and beta 1 subunits were detectable in membranes prepared from the human soleus muscle. The alpha 1 subunit was largely detected in a fraction enriched with plasma membranes (PM), its abundance in an intracellular membrane fraction (IM) accounted for only 4% of that in the PM fraction. No alpha 1 subunits were detected in membranes of sarcoplasmic reticulum (SR) origin. The PM and IM fractions were enriched with alpha 2 subunits which were less abundant in the SR-enriched fraction. The abundance of alpha 2 molecules within the IM fraction was about 75% of that in the PM fraction when the total protein content for the two fractions was taken into account. Immunocytochemical studies confirmed the localization of the alpha 1 subunit to the muscle cell surface. The alpha 2 subunit was also found to be present in the cell surface but the observation that alpha 2 immunofluorescence was diffusely dispersed throughout the muscle fibre indicated that it was also present intracellularly, consistent with its biochemical localization in the PM and IM membrane fractions. The alpha 3 subunit was detected largely in the PM fraction but the lack of good antibodies to this isoform precluded an analysis of its immunocytochemical localization. The beta 1 subunit was enriched in the PM fraction but was also detected to a modest extent in the IM.(ABSTRACT TRUNCATED AT 250 WORDS)


Advances in Experimental Medicine and Biology | 1998

Amino Acid Transport during Muscle Contraction and Its Relevance to Exercise

Michael J. Rennie; Sylvia Y. Low; Peter M. Taylor; Shihab E. O. Khogali; Pei-Chin Yao; Aamir Ahmed

The functional significance of amino acid transport in skeletal muscle has been explored by the use of a variety of techniques including work in isolated perfused organs, isolated incubated organs and tissue culture of muscle cells. The results suggest that although there is a wide variety of amino acid transport systems of different characteristics and with different responses to ionic, hormonal and nervous modulation, the amino acid glutamine (transported by system Nm) demonstrates some unusual properties not observed with amino acids transported by other systems. Glutamine is transported at very high rates in skeletal muscle and heart and both the glutamate and glutamine transporter appear to be adaptively regulated by the availability of glutamine. Glutamine appears to be involved in the regulation of a number of important metabolic processes in heart and skeletal muscle (e.g., regulation of the glutathione reduced/oxidised ratio and regulation of protein and glycogen synthesis). Furthermore, glutamine transport appears to interact with systems for regulation of volume control and many of the metabolic features attributable to changes in glutamine concentration appear to be modulated via alteration in cytoskeletal status.


Journal of Nutrition | 1996

Glutamine Metabolism and Transport in Skeletal Muscle and Heart and Their Clinical Relevance

Michael J. Rennie; Aamir Ahmed; Shihab E. O. Khogali; Sylvia Y. Low; Harinder S. Hundal; Peter M. Taylor


Journal of Nutrition | 1994

Glutamine Transport and Its Metabolic Effects

Michael J. Rennie; Labib Tadros; Shihab E. O. Khogali; Aamir Ahmed; Peter M. Taylor


Biochemical Journal | 1992

Biochemical and immunocytochemical localization of the 'GLUT5 glucose transporter' in human skeletal muscle.

H S Hundal; Aamir Ahmed; A Gumà; Y Mitsumoto; André Marette; Michael J. Rennie; Amira Klip


American Journal of Physiology-endocrinology and Metabolism | 1993

Glutamine transport in human skeletal muscle

Aamir Ahmed; D. L. Maxwell; Peter M. Taylor; Michael J. Rennie


Biochemical Society Transactions | 1996

Amino acid transport in heart and skeletal muscle and the functional consequences

Michael J. Rennie; Shihab E. O. Khogali; Sylvia Y. Low; H. E. McDowell; H S Hundal; Aamir Ahmed; Peter M. Taylor


Journal of Biological Chemistry | 1995

Sodium-independent Currents of Opposite Polarity Evoked by Neutral and Cationic Amino Acids in Neutral and Basic Amino Acid Transporter cRNA-injected Oocytes

Aamir Ahmed; George J. Peter; Peter M. Taylor; Alexander A. Harper; Michael J. Rennie


Biochemical Journal | 1991

Substrate-specificity of glutamine transporters in membrane vesicles from rat liver and skeletal muscle investigated using amino acid analogues.

Sylvia Y. Low; Peter M. Taylor; Aamir Ahmed; Christopher I. Pogson; Michael J. Rennie


American Journal of Physiology-endocrinology and Metabolism | 1990

Characteristics of glutamine transport in sarcolemmal vesicles from rat skeletal muscle

Aamir Ahmed; Peter M. Taylor; Michael J. Rennie

Collaboration


Dive into the Aamir Ahmed's collaboration.

Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Researchain Logo
Decentralizing Knowledge