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Aaron M. Kearney

Johnson & Johnson Pharmaceutical Research and Development

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Featured researches published by Aaron M. Kearney.

Bioorganic & Medicinal Chemistry Letters | 2011

Tricyclic aminopyrimidine histamine H4 receptor antagonists

Brad M. Savall; Laurent Gomez; Frank Chavez; Michael P. Curtis; Steven P. Meduna; Aaron M. Kearney; Paul J. Dunford; Jeffery M. Cowden; Robin L. Thurmond; Cheryl A. Grice; James P. Edwards

This report discloses the development of a series of tricyclic histamine H(4) receptor antagonists. Starting with a low nanomolar benzofuranopyrimidine HTS hit devoid of pharmaceutically acceptable properties, we navigated issues with metabolism and solubility to furnish a potent, stable and water soluble tricyclic histamine H(4) receptor antagonist with desirable physiochemical parameters which demonstrated efficacy a mouse ova model.

Tetrahedron Letters | 2010

Palladium-catalyzed benzylation of N-Boc indole boronic acids

Aaron M. Kearney; Adrienne M. Landry-Bayle; Laurent Gomez

Archive | 2010

Verbindungen mit zwei bicyclischen heteroarylderivaten als modulatoren von leukotrien-a4-hydrolase

Genesis M. Bacani; Christa C. Chrovian; Wendy Eccles; Anne M. Fourie; Laurent Gomez; Cheryl A. Grice; Aaron M. Kearney; Adrienne M. Landry-Bayle; Alice Lee-Dutra; Alejandro Santillan; Virginia M. Tanis; John J. M. Wiener

Archive | 2010

Verbindungen mit zwei kondensierten bicyclischen heteroarylteilen als modulatoren der leukotrien-a4-hydrolase

Archive | 2010

Compounds with two fused bicyclic heteroaryl moieties as modulators of leukotriene a4 hydrolase

Archive | 2010

Composés possédant deux groupements hétéroaryle bicycliques condensés en tant que modulateurs de la leucotriène a4 hydrolase

Genesis M. Bacani; Christa C. Chrovian; Wendy Eccles; Anna M. Fourie; Laurent Gomez; Cheryl A. Grice; Aaron M. Kearney; Adrienne M. Landry-Bayle; Alice Lee-Dutra; Alejandro Santillan; Virginia M. Tanis; John J. M. Wiener

Archive | 2009

Thiazolopyridin-2-yloxy-phenyl- und thiazolopyrazin-2-yloxy-phenyl-amine als modulatoren von leukotrien-a4-hydrolase

Genesis M. Bacani; Diego Broggini; Eugene Y. Cheung; Christa C. Chrovian; Xiaohu Deng; Anne M. Fourine; Laurent Gomez; Cheryl A. Grice; Aaron M. Kearney; Adrienne M. Landry-Bayle; Alice Lee-Dutra; Jimmy T. Liang; Susanne Lochner; Neelakandha S. Mani; Alejandro Santillan; Kathleen C. Sappey; Kia Sepassi; Virginia M. Tanis; Alvah T. Wickboldt; John J. M. Wiener; Hartmut Zinser

Archive | 2009

Thiazolopyridin-2-yloxy-phényle et thiazolopyrazin-2-yloxy-phényl amines en tant que modulateurs de la leukotriène a4 hydrolase

Genesis M. Bacani; Diego Broggini; Eugene Y. Cheung; Christa C. Chrovian; Xiaohu Deng; Anne M. Fourine; Laurent Gomez; Cheryl A. Grice; Aaron M. Kearney; Adrienne M. Landry-Bayle; Alice Lee-Dutra; Jimmy T. Liang; Susanne Lochner; Neelakandha S. Mani; Alejandro Santillan; Kathleen C. Sappy; Kia Sepassi; Virginia M. Tanis; Alvah T. Wickboldt; John J. M. Wiener; Hartmut Zinser

Archive | 2009

Amines de thiazolopyridin-2-yloxy-phenyl et de thiazolopyrazin-2-yloxy-phenyl en tant que modulateurs de leukotriene a4 hydrolase

Hartmut Zinser; Genesis M. Bacani; Diego Broggini; Eugene Y. Cheung; Christa C. Chrovian; Xiaohu Deng; Anne M. Fourine; Laurent Gomez; Cheryl A. Grice; Aaron M. Kearney; Adrienne M. Landry-Bayle; Alice Lee-Dutra; Jimmy T. Liang; Susanne Lochner; Neelakandha S. Mani; Alejandro Santillan; Kathleen C. Sappey; Kia Sepassi; Virginia M. Tanis; Alvah T. Wickboldt; John J. M. Wiener

Archive | 2008

Aryl-substituierte überbrückte oder kondensierte diamine als modulatoren von leukotrien-a4-hydrolase

Genesis M. Bacani; Scott D. Bembenek; Wendy Eccles; James P. Edwards; Matthew T. Epperson; Laurent Gomez; Cheryl A. Grice; Aaron M. Kearney; Adrienne M. Landry-Bayle; Alice Lee-Dutra; Kelly J. Mcclure; Taraneh Mirzadegan; Alejandro Santillan

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