Aaron Walfish

Association between serum vitamin D levels and gastric cancer: A retrospective chart analysis.

AIM To determine whether there is an increased risk of gastric adenocarcinoma associated with vitamin D deficiency (VDd). METHODS A retrospective case control study was performed of all patients diagnosed with gastric adenocarcinoma between 2005 and 2015. After we excluded the patients without a documented vitamin D level, 49 patients were included in our study. RESULTS The average age of patients with gastric adenocarcinoma and documented vitamin D level was 64 years old (95%CI: 27-86) and average vitamin D level was 20.8 mg/dL (95%CI: 4-44). Compared to a matched control group, the prevalence of VDd/insufficiency in patients with gastric adenocarcinoma was significantly higher than normal vitamin D levels (83.7% vs 16.3%). Forty-one patients (83.7%) with adenocarcinoma showed VDd/insufficiency compared to 18 (37%) patients with normal vitamin D level without gastric cancer (OR: 8.8, 95%CI: 5-22, P value < 0.0001). The average age of males with gastric adenocarcinoma diagnosis was 60 years old vs 68 years old for females (P = 0.01). Stage II gastric adenocarcinoma was the most prevalent in our study (37%). CONCLUSION We reported a positive relationship between VDd and gastric adenocarcinoma, that is to say, patients with decreased VDd levels have an increased propensity for gastric adenocarcinoma.

Acute hepatitis E presenting with clinical feature of autoimmune hepatitis

A 32-year-old immigrant man presented with new onset jaundice. His past medical history was significant for type 2 diabetes mellitus, hypertension, and hyperlipidemia. His initial laboratory finding and liver biopsy were suggestive of autoimmune hepatitis (AIH). The plan was to start steroids pending negative results for viral serology, but it came back positive for hepatitis E virus. The patients liver function test and clinical condition improved significantly on conservative management over a period of 1 month. Therefore, we suggest testing for hepatitis E especially in immigrants or recent travelers to endemic areas who presents with clinical features suggestive of AIH.

Primary squamous cell carcinoma of the rectum: a case report and literature review.

Squamous cell carcinoma (SCC) of the rectum is a rare occurrence with an incidence rate of 0.1–0.25% per 1,000 cases. Herein, we report a case of a 52-year-old female who presented with a 2-month history of diffuse lower abdominal pain and hematochezia. Abdominal CT scan revealed a 7-cm irregular rectal mass, and the biopsy showed SCC.

Cytomegalovirus triggering autoimmune hepatitis: case report and literature review -

Cytomegalovirus (CMV) is considered to play a role in triggering autoimmune hepatitis (AIH). It is difficult to diagnose autoimmune hepatitis because its presentation can be acute, severe, asymptomatic or chronic. Diagnosis requires multiple findings and exclusions of similar diseases. When excluding, viral etiologies are part of the differential, which in this case is CMV. If a trigger is required to set off a sequence of events leading to autoimmune hepatitis in these predisposed individuals, viruses are among the most likely candidates. In this study, a case of a 54 year-old female who presents with new onset of jaundice, associated with abdominal distension, lower extremity edema and 10 pound weight gain is reported. The autoimmune workup of the patient was significant for an elevated antibodies to nuclei (ANA) titer, anti-smooth muscle ab titer and a significant increase in immunoglobulins, specifically IgG. Interestingly, CMV Ab IgM was positive as well as CMV Ab IgG. A liver biopsy was performed which showed heavy infiltration with lymphoplasmacytic inflammatory cells, interface hepatitis, bridging necrosis and fibrosis. These pathologic and laboratory findings led us to a definitive diagnosis of AIH Type 1. In the setting of positive CMV IgG and IgM ab titers, we suggest that the trigger for AIH in this case was a preceding CMV infection. Patient improved with combination of azathioprine and corticosteroid therapy despite intermittent flares of the patient’s AIH.

Acute Gastric Ischemia After Chemoembolization in a Patient with Hepatocellular Carcinoma

A 72-year-old man presented with severe diffuse abdominal pain and melena. His past history was significant for hepatitis C cirrhosis and hepatocellular carcinoma status post partial resection five years ago and recurrent malignant lesions treated with multiple sessions of transarterial chemoembolization (TACE). He had received his last TACE treatment of a lesion in segment 6 via a distal branch of the right renal artery 2.5 months prior to the presentation. His examination was significant for moderate abdominal distension and tenderness. Laboratory findings were notable for the following: hemoglobin, 7.4 g/dl; creatinine, 2.4 mg/dl; and lactate, 10.1 mmol/l. Initial computerized tomography of the abdomen/pelvis without contrast showed cirrhosis and a hepatic mass, a markedly distended stomach, and gas in the gastric wall, an intrahepatic portion of the portal vein, and the gastric veins (a). Esophagogastroduodenoscopy showed ulceration and necrosis localized to the fundus and proximal lesser curvature (b). The patient was managed conservatively with bowel rest, intermittent nasogastric tube suction, intravenous (IV) fluids, IV pantoprazole, and broad-spectrum antibiotics. He responded well to medical management, showing marked improvement on repeat imaging with contrast (c). (Informed consent was obtained from the patient to publish these images.)