Abdelwahed R. Sayed

Synthesis and Biological Evaluation of Bisthiazoles and Polythiazoles

Small heterocyclic compounds containing nitrogen and sulfur atoms, such as thiazole derivatives, represent a significant class of organic azoles that exhibit promising bioactivities and have a great potential in medicinal and agricultural fields. A convenient and high-yielding synthetic approach for a range of organic molecules is presented. The nuclease-like activities of compounds were studied with the aid of E. coli AB1157 DNA and agarose gel electrophoresis. The antioxidant evaluation of the compounds was carried out with different antioxidant techniques, such as ABTS and NO scavenging efficiency. The antibacterial behavior was evaluated against various bacterial strains, both Gram-positive and -negative, and the minimum inhibitory concentration (MIC) values of these compounds were determined. The antiproliferative activities and IC50 values of the synthesized organic molecules compounds against HEPG-2, MCF-7, and HCT-116 cell lines were evaluated.

Polyhydrazide Incorporated with Thiadiazole Moiety as Novel and Effective Corrosion Inhibitor for C-Steel in Pickling Solutions of HCl and H2SO4

In this paper polyhydrazide incorporated with thiadiazole moiety (S5) was prepared and its chemical configuration was confirmed by spectroscopic methods (FTIR, 1H NMR, and 13C NMR). The inhibitive action of S5 polymer and its monomer 2,5-dihydrazinyl-1,3,4-thiadiazole (M1) on the C-steel corrosion in pickling acids solution was investigated by weight loss, potentiodynamic polarization (PDP) and electrochemical impedance spectroscopy (EIS) measurements. PDP method exhibited that the investigated polymer is mixed-type corrosion inhibitor in both acids (HCl and H2SO4). The data revealed that S5 compound is a good inhibitor for Csteel in studied acids, and protection efficiency (P%) follows this sequence: H2SO4<HCl. Also, it was found that, the P% of the S5 polymer is higher than that obtained for its monomer (M1). Adsorption of the titled polymer obeyed the isotherm of Langmuir and involves both chemical and physical adsorptions. Scanning electron microscopy (SEM) investigations established the protective layer formation from the studied polymer on the metal substrate and shield it from direct Cl- and/ or

Synthesis and Characterization of Bisimidazoles, Bistriazoles, Bisthiadiazoles, and Bisthiazoles from Novel Bishydrazonoyl Dichlorides

\rm{SO}_4^2-

Synthesis and characterization of novel heterocycles based on tetrazine and hydrazonoyl halides

SO42− attack.

Design, Synthesis, and Characterization of Some New bis-thiazoles

Synthesis and characterization of new thiadiazoles, bisthiadiazoles from the reaction of mono- and di-hydrazonoyl halides with various hydrazinecarbodithioate derivatives were studied. Treatment of hydrazonoyl halides with 2,5-dihydrazinyl-1,3,4-thiadiazole afforded new bistriazines containing thiadiazole; we also examined the reaction of 2,5-dihydrazinyl-1,3,4-thiadiazole with active methylene compounds to afford new pyrazoles containing thiadiazole compounds. The new synthesized compounds were identified by elemental analysis and various spectral data (Fourier transform infrared spectroscopy, mass spectrometry, 1H and 13C nuclear magnetic resonance).