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Dive into the research topics where Abdoulaye Dione Diop is active.

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Featured researches published by Abdoulaye Dione Diop.


Fundamental & Clinical Pharmacology | 2009

Efficacy of four insect repellents against mosquito bites: a double-blind randomized placebo-controlled field study in Senegal.

Bernard Uzzan; Lassana Konate; Abdoulaye Dione Diop; Patrick Nicolas; Ibrahima Dia; Yémou Dieng; Arezki Izri

Insect‐borne diseases represent a worldwide threat. In addition to fight against vectors (insecticides) and disease prevention (vaccination against yellow fever, chemoprophylaxis against malaria), insect repellents applied on the skin could help reduce the heavy burden related to these diseases. In a field study performed in Senegal, we compared the efficacy of one skin application between 3 and 4 p.m. of four spray repellents [icaridine 20%, para‐menthane‐diol (PMD) 20% and 50% and DEET 50%] against placebo, among 100 healthy male and female volunteers experienced with mosquito capture. Double‐blind randomized cross‐over placebo‐controlled study (Latin‐square design) during five consecutive nights (7 p.m. to midnight) in two villages was conducted. To avoid residual effect, right or left leg was alternately exposed during consecutive nights and the exposed leg was washed before next night. The statistical model was random and mixed effects anova. All four active repellents provided a significant and similar protection compared with placebo, lasting 8 h. However, there was a non‐significant trend for a higher protection by DEET 50% than by PMD 20% (P = 0.07). Duration of protection was similar for all repellents. Their effects were similar among men and women, and against Anopheles or other species. No serious adverse drug reaction was noticed. Using a rigorous methodology and a large number of volunteers, our well‐controlled study demonstrated an important and similar protective effect of all four repellents compared with placebo. Such field studies should be required before approval of any newly developed repellent.


Medical mycology case reports | 2016

Tinea pedis due to Cylindrocarpon lichenicola beginning onycholysis.

K. Diongue; M. Diallo; M.C. Seck; M. Ndiaye; A.S. Badiane; Abdoulaye Dione Diop; Yaye Die Ndiaye; Omar Ndir; Daouda Ndiaye

A 33 year old woman presented with both feet, humid and white Tinea pedis at the second, third and fourth inter-toes areas associated with a beginning onycholysis of the nails lasting for 18 months. KOH mount of the samples was positive for fungal hyphae. The fungus was isolated on Sabouraud-chlorampphenicol agar and identified as Cylindrocarpon lichenicola. The patient was treated with an association of terbinafine tablet and terbinafine cream and presented clinical cure after three months.


Open Journal of Radiology | 2018

High-Field MRI Contribution in Tolosa-Hunt Syndrome (THS). Report of Two Cases and Review of Literature

Cherif Mohamadou Aidara; Philomène Kouna; Jennifer Nyangui Mapaga; Nfally Badji; Hamidou Deme; Abdoulaye Dione Diop; Abdoulaye Ndoye Diop; Sokhna Diop Ba; El Hadj Niang

Background: Tolosa Hunt Syndrome is an inflammatory condition of unknown etiology of the cavernous sinus and superior orbital fissure. Because of the difficulty in establishing histological evidence, his diagnosis is based on a set of arguments established by the International Headache Society. MRI allows indirect visualization of the granuloma and plays a key role in diagnosis and follow-up. Aim: To illustrate High-field MRI contribution in Tolosa-Hunt Syndrome (THS). Cases Presentation: Two patients, a 25-year-old female and a 40-year-old male were recruited in this retrospective case report study at the Radiology service of Fann University Hospital (Dakar Senegal). The first patient has been suffering from a right retro-orbital pain and diplopia for 2 months and the second from a painful oculomotor nerve palsy for 3 months. Blood tests, lumbar puncture, thyroid hormone levels and an infectious screen were done. Screening for converting enzymes, and serum antibodies were also done. They underwent a high field MRI (Siemens 1.5T) with T1, T2, FLAIR, T2*, diffusion B1000, TOF polygon, CISS 3D and T1 gadolinium sequences in the 3 planes space. No significant abnormality was detected in blood tests or CSF analysis. Screening for converting enzymes and serum antibodies screen were also negative. For each patient, MRI examinations showed a non tumoral thickening of the right cavernous sinus, suggesting a granulomatous involvement. Tolosa Hunt Syndrome was evoked firstly. They were put on corticotherapy at high doses with a spectacular regression of symptoms. The Criteria of the International Headache Society of THS were met in both patients. Conclusion: High-field MRI is a significant diagnostic tool in the assessment of painful ophthalmoplegia. It allows a direct visualization of the granuloma of the cavernous sinus and assesses its course throughout the disease.


Malaria Journal | 2018

Insecticide resistance in Anopheles arabiensis populations from Dakar and its suburbs: role of target site and metabolic resistance mechanisms

A. Kane Dia; O. Kalsom Guèye; E. Amadou Niang; S. Mocote Diédhiou; M. Demba Sy; Abdoulaye Konaté; Badara Samb; Abdoulaye Dione Diop; Lassana Konate; Ousmane Faye

BackgroundUrban malaria is an increasing concern in most of the sub-Saharan Africa countries. In Dakar, the capital city of Senegal, the malaria epidemiology has been complicated by recurrent flooding since 2005. The main vector control measure for malaria prevention in Dakar is the community use of long-lasting insecticide-treated nets. However, the increase of insecticide resistance reported in this area needs to be better understood for suitable resistance management. This study reports the situation of insecticide resistance and underlying mechanisms in Anopheles arabiensis populations from Dakar and its suburbs.ResultsAll the populations tested showed resistance to almost all insecticides except organophosphates families, which remain the only lethal molecules. Piperonil butoxide (PBO) and ethacrinic acid (EA) the two synergists used, have respectively and significantly restored the susceptibility to DDT and permethrin of Anopheles population. Molecular identification of specimens revealed the presence of An. arabiensis only. Kdr genotyping showed the presence of the L1014F mutation (kdr-West) as well as L1014S (kdr-East). This L1014S mutation was found at very high frequencies (89.53%) in almost all districts surveyed, and in association with the L1014F (10.24%).ConclusionResults showed the contribution of both target-site and metabolic mechanisms in conferring pyrethroid resistance to An. arabiensis from the flooded areas of Dakar suburbs. These data, although preliminary, stress the need for close monitoring of the urban An. arabiensis populations for a suitable insecticide resistance management system to preserve core insecticide-based vector control tools in this flooded area.


Archive | 2017

Rare cutaneous tuberculosis in Sub-Saharan Africa developed on discoid lupus erythematous lesion

Abdoulaye Dione Diop; M. Ndiaye; B. Seck; A. Diouf; B.H. Diatta; M. Diallo; F. Ly

Lupus vulgaris is a common presentation of cutaneous tuberculosis (TB), but its ulcerative or vegetating form also called vorax is rare.We report a case of lupus vulgaris in its vorax form, which occurred in a patient with discoid lupus erythematous. A 42-year-old patient monitored for chronic lupus erythematosus consulted again for a facial tumor and fever. Physical examination revealed painful ulcerative and crusted lesions on an old discoid lupus lesion and covered the entire upper lip. Similar lesions were noted on cheeks. Moreover, there were cervical lymphadenopathy, a bilateral pulmonary condensation syndrome, and dysphonia. Cutaneous histopathology had revealed a tuberculoid granuloma without caseating, and nucleic acid amplification tests (GeneXpert®) performed on sputum were positive. Thus, the diagnosis of multifocal TB with skin involvement of vorax type was confirmed. The outcome was favorable following TB treatment. Our observation is distinctive as it is a granulomatosis and ulcerative form of lupus vulgaris, which occurred on a discoid lupus erythematous lesion. This is a rare form of lupus vulgaris. This scarcity can be explained by diagnostic difficulties as there are numerous differential diagnoses and histopathology is not often helpful.


Bulletin De La Societe De Pathologie Exotique | 2017

Une tuberculose cutanée rare en Afrique subsaharienne sur une lésion de lupus discoïde@@@Rare cutaneous tuberculosis in Sub-Saharan Africa developed on discoid lupus erythematous lesion

Abdoulaye Dione Diop; M. Ndiaye; B. Seck; A. Diouf; B.H. Diatta; M. Diallo; F. Ly

Lupus vulgaris is a common presentation of cutaneous tuberculosis (TB), but its ulcerative or vegetating form also called vorax is rare.We report a case of lupus vulgaris in its vorax form, which occurred in a patient with discoid lupus erythematous. A 42-year-old patient monitored for chronic lupus erythematosus consulted again for a facial tumor and fever. Physical examination revealed painful ulcerative and crusted lesions on an old discoid lupus lesion and covered the entire upper lip. Similar lesions were noted on cheeks. Moreover, there were cervical lymphadenopathy, a bilateral pulmonary condensation syndrome, and dysphonia. Cutaneous histopathology had revealed a tuberculoid granuloma without caseating, and nucleic acid amplification tests (GeneXpert®) performed on sputum were positive. Thus, the diagnosis of multifocal TB with skin involvement of vorax type was confirmed. The outcome was favorable following TB treatment. Our observation is distinctive as it is a granulomatosis and ulcerative form of lupus vulgaris, which occurred on a discoid lupus erythematous lesion. This is a rare form of lupus vulgaris. This scarcity can be explained by diagnostic difficulties as there are numerous differential diagnoses and histopathology is not often helpful.


Bulletin De La Societe De Pathologie Exotique | 2017

Une tuberculose cutanée rare en Afrique subsaharienne sur une lésion de lupus discoïde

Abdoulaye Dione Diop; M. Ndiaye; B. Seck; A. Diouf; B.H. Diatta; M. Diallo; F. Ly

Lupus vulgaris is a common presentation of cutaneous tuberculosis (TB), but its ulcerative or vegetating form also called vorax is rare.We report a case of lupus vulgaris in its vorax form, which occurred in a patient with discoid lupus erythematous. A 42-year-old patient monitored for chronic lupus erythematosus consulted again for a facial tumor and fever. Physical examination revealed painful ulcerative and crusted lesions on an old discoid lupus lesion and covered the entire upper lip. Similar lesions were noted on cheeks. Moreover, there were cervical lymphadenopathy, a bilateral pulmonary condensation syndrome, and dysphonia. Cutaneous histopathology had revealed a tuberculoid granuloma without caseating, and nucleic acid amplification tests (GeneXpert®) performed on sputum were positive. Thus, the diagnosis of multifocal TB with skin involvement of vorax type was confirmed. The outcome was favorable following TB treatment. Our observation is distinctive as it is a granulomatosis and ulcerative form of lupus vulgaris, which occurred on a discoid lupus erythematous lesion. This is a rare form of lupus vulgaris. This scarcity can be explained by diagnostic difficulties as there are numerous differential diagnoses and histopathology is not often helpful.


Journal of Pigmentary Disorders | 2015

Genetic and Neuro-Imaging Aspects in Neurofibromatosis 1

Cherif Mohamadou Aidara; Lucien Mwanyombet; Abdoulaye Dione Diop; Ahmed Dia; Abdoulaye Ndoye Diop; Sokhna Diop Ba

Cherif Mohamadou Aidara1*, Lucien Mwanyombet2, Abdoulaye Dione Diop1, Ahmed Dia1, Abdoulaye Ndoye Diop1 and Sokhna Ba1 1Radiology Service of Fann University Hospital, Cheikh Anta Diop Street BP 5035, Dakar, Senegal 2Sugeon Service of Polyclinique El Rapha, BP 256 Libreville, Gabon *Corresponding author: Cherif Mohamadou Aidara, Radiology Service of Fann University Hospital, Cheikh Anta Diop Street BP 5035, Dakar, Senegal, Tel: 00221706133605; E-mail: [email protected]


Journal De Mycologie Medicale | 2015

Kératomycose à Fusarium oxysporum traitée par l’association de la povidone iodée en collyre et du fluconazole per os

K. Diongue; A.S. Sow; M. Nguer; M.C. Seck; M. Ndiaye; A.S. Badiane; J.M. Ndiaye; N.W. Ndoye; M. Diallo; Abdoulaye Dione Diop; Y.D. Ndiaye; B. Dieye; A. Déme; I.M. Ndiaye; Omar Ndir; Daouda Ndiaye

In developing countries where systemic antifungal are often unavailable, treatment of filamentous fungi infection as Fusarium is sometimes very difficult to treat. We report the case of a keratomycosis due to Fusarium oxysporum treated by povidone iodine eye drops and oral fluconazole. The diagnosis of abscess in the cornea was retained after ophthalmological examination for a 28-year-old man with no previous ophthalmological disease, addressed to the Ophthalmological clinic at the University Hospital Le Dantec in Dakar for a left painful red eye with decreased visual acuity lasting for 15 days. The patient did not receive any foreign body into the eye. Samples by corneal scraping were made for microbiological analysis and the patient was hospitalized and treated with a reinforced eye drops based treatment (ceftriaxone+gentamicin). The mycological diagnosis revealed the presence of a mold: F. oxysporum, which motivated the replacement of the initial treatment by eye drops containing iodized povidone solution at 1% because of the amphotericin B unavailability. Due to the threat of visual loss, oral fluconazole was added to the local treatment with eye drops povidone iodine. The outcome was favorable with a healing abscess and visual acuity amounted to 1/200th. Furthermore, we noted sequels such as pannus and pillowcase. The vulgarization of efficient topical antifungal in developing countries would be necessary to optimize fungal infection treatment.


Journal of Medical Entomology | 1997

Comparison of behavior and vector efficiency of Anopheles gambiae and An. arabiensis (Diptera: Culicidae) in Barkedji, a Sahelian Area of Senegal

Jean-Jacques Lemasson; D. Fontenille; Laurence Lochouarn; Ibrahima Dia; Frederic Simard; Khalilou Ba; Abdoulaye Dione Diop; Mathurin Diatta; Jean-François Molez

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M. Diallo

Cheikh Anta Diop University

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M. Ndiaye

Cheikh Anta Diop University

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Sokhna Ba Diop

Cheikh Anta Diop University

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A.S. Badiane

Cheikh Anta Diop University

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K. Diongue

Cheikh Anta Diop University

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Lassana Konate

Cheikh Anta Diop University

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M.C. Seck

Cheikh Anta Diop University

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A Mbengue

Cheikh Anta Diop University

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