Abhijeet Deb Roy

Real time HR-MAS NMR: application in reaction optimization, mechanism elucidation and kinetic analysis for heterogeneous reagent catalyzed small molecule chemistry.

A novel application of in situ 1H high‐resolution magic angle spinning (HR–MAS) NMR technique for real‐time monitoring of H2SO4‐silica promoted formation of 2, 2‐disubstituted quinozolin‐4(3H)‐ones is reported. The detailed NMR spectroscopic data led to elucidation of the mechanism, reaction optimization, kinetics and quantitative analysis of the product accurately and efficiently. The translation of the optimized parameters obtained by 1H HR–MAS NMR in the wet laboratory provided similar results. It is proposed that 1H HR‐MAS has a potential utility for optimization of various organic transformations in solid supported catalyzed reactions. Copyright

Stereoselective synthesis of highly O-functionalized enantiopure 2,3,4-trisubstituted tetrahydrofurans by tandem debenzylative cyclization of glycal derived 2,3-epoxy alcohols

A new and highly efficient methodology for the construction of synthetically important highly O-functionalized enantiopure 2,3,4-trisubstituted tetrahydrofurans with three contiguous stereocenters is reported.