Abhijeet Ojha

Prevalence of Depression among Geriatric People in Dehradun City of Uttarakhand, India

Depression is a medical problem that is commonly seen among geriatric people which is sometimes unrecognized public health problem. So, a study was conducted in 200 geriatric people with the help of brief questionnaire in which the respondents were ask to respond to 30 questions as per long form of Geriatric Depression Scale (GDS) to determine the prevalence of depression among older people in Dehradun District of Uttarakhand. It was responded by 88.5% of geriatric population. Most of the geriatrics (58.75%) were in age group of 60- 69, while least number (6.21%) were found in age group of 80-89. Fifty-three (29.94%) geriatric were found to be depressed as per GDS score. As per financial status was concerned 139(78.53%) geriatric population was financially independent and 38(21.46%) geriatric population was financially dependent. Out of 177 respondents, 32(18.07%) financially dependent and 21(11.86%) financially independent geriatric population was found to be depressed. It was also observed that 136(76.83%) were living in joint families and 41(23.16%) were living in nuclear families. The present study suggests substantial proportion (29.94%) of geriatric people are suffering from depression based on GDS standard method of screening geriatric subjects. And concluded that proper interventions are required from healthcare professionals to overcome the problem of depression in the community.

Development and evaluation of nanosized aripiprazole-loaded bioflexy films using a biopolymer from Lagenaria siceraria for brain delivery through orosoft palatal mucosal platform

Purpose The National Institute of Mental Health estimated the global cost of mental illness to be

Isolation and characterization of novel mucoadhesive biomaterial from Phoenix dactylifera

6T by 2030. The purpose of the study was to deliver aripiprazole for brain targeting by suitably designing a bioflexy film for the treatment of different brain disorders. Materials and methods Bioflexy films were prepared by solvent casting technique using aripiprazole as a model drug, different concentrations of isolated biopolymer from Lagenaria siceraria, and a standard polymer. Results All formulations of aripiprazole were flexible, smooth, and transparent in nature, with a weight range from 23.73 to 34.48 mg, pH range from 7.27 to 7.39, and folding endurance of 94–116 times. The content uniformity was in the range of 97.2–98.6. Conclusion In-vitro and in-vivo release shows FL2 as the best formulation. On the basis in-vitro and in-vivo drug release, FL2 was found to be best formulation showing mucoadhesivity (36 h), t50% of 2.5 h, t80% of 23.4 h, and having R2 value of 0.9923, best-fit model Higuchi matrix analyzed by BIT-SOFT 1.12. Moreover, it was observed that significant amount of drug reaches to the brain through soft palatal route through neural pathway.