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Dive into the research topics where Abraham Weber is active.

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Featured researches published by Abraham Weber.


Journal of Medicinal Chemistry | 1989

Fluoronaphthyridines and quinolones as antibacterial agents. 2. Synthesis and structure-activity relationships of new 1-tert-butyl 7-substituted derivatives.

Daniel Bouzard; P. Di Cesare; Munir Essiz; Jean-Pierre Jacquet; Philippe Remuzon; Abraham Weber; T. Oki; M. Masuyoshi

A number of 7-substituted-1-tert-butyl-6-fluoroquinolone-3-carboxylic acids and 7-substituted-1-tert-butyl-6-fluoro-1,8-naphthyridine-3-carboxylic acids have been prepared and tested for antibacterial activities. Among those the 7-aminopyrrolidinyl 20b and the 7-diazabicyclo naphthyridine 18b are the most potent compounds in vitro and in vivo. Physicochemical data and acute toxicity are also discussed. Compound 18b, BMY 40062, exhibits the most favorable overall properties, considering in vitro and in vivo microbiological activity, its low toxicity, and pharmacokinetic profile, and was selected for clinical evaluation.


Archive | 1987

1-Tert-alkyl-substituted naphthyridine and quinoline carboxylic acids as antibacterial agents.

Cesare Pierre Di; Jean-Pierre Jacquet; Munir Essiz; Philippe Remuzon; Daniel Bouzard; Abraham Weber


Archive | 1979

Process for the preparation of the crystalline monohydrate of 7-(D-α-aα-(p-hydroxyphenyl)acetamido)-3-methyl-3-cephem-4-carboxylic acid

Daniel Bouzard; Abraham Weber; Jacques Stemer


Archive | 1988

1-tertiary-alkyl-substituted naphthyridine carboxylic acid antibacterial agents

Abraham Weber; Daniel Bouzard; Munir Essiz; Pierre Di Cesare; Jean-Pierre Jacquet; Philippe Remuzon


Archive | 1975

α-Amino and α-formyl-α-(p-acyloxyphenyl)acetamidocephalosporanic acid derivatives

Daniel Bouzard; Abraham Weber


Archive | 1988

Certain 1-tertiary-butyl-naphthyridone carboxylic acid derivatives anti-bacterial agents

Abraham Weber; Daniel Bouzard; Munir Essiz; Pierre Di Cesare; Jean-Pierre Jacquet; Philippe Remuzon


Archive | 1980

Pharmaceutical formulations of 4'-(9-acridinylamino)-methanesulfon-m-anisidide

Murray Arthur Kaplan; Daniel Bouzard; Claude Perol; Jacques Stemer; Abraham Weber


Archive | 1975

Enzymatic preparation of 6-D-(-)-α-amino-α-(p-hydroxyphenylacetamino)penicillin acid

Daniel Bouzard; Abraham Weber


Archive | 1977

7-D-α-Amino-.alpha.-(p-acetoxyphenyl)acetamido-3-methyl-3-cephem-4-carboxylic acid

Daniel Bouzard; Abraham Weber


Archive | 1982

Crystalline glucoconate salt of m-AMSA and compositions containing same

Daniel Bouzard; Claude Perol; Jacques Stemer; Abraham Weber; Edmund S Granatek

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