Achmad Tjarta

EKSPRESI PROTEIN NM 23-H1 PADA BERBAGAI POLA PERTUMBUHAN KARSINOMA SEL BASAL

Hemolytic uremic syndrome (HUS) is deJined by the triad of microangiopathic hemolytic anemia, thrombocytopenia and acute renal failure (ARF) that develop acutely in an otherwise healthy child. It is one of the most common causes of ARF in children and carried high mortality. Within the period of ten years (January 1980 December 1987) we retrospectively reviewed 9 cases of HUS out of 25.309 cases hospitalized at the same period, consisting or 5 males and 4 females, age ranged between 1 12 years (mean age: 7.1 years). Only one case was below 5 years, the rest have ages of 5 years or more. Prodromal illness detected in our cases includedfever (8 cases); vomiting (5 cases) and diarrhea (4 cases), one of them with bloody diarrhea. Noteworthy presenting clinical features included fever and pallor that were detected in all cases, bleeding (5 cases), hepatomegaly (5 cases), neurologic deficit such as drowsiness, lethargy and seizures (4 cases) and oliguria (7 cases). All cases showed hemolytic anemia, thrombocytopenia and renal insuflciency on laboratory investigation. Metabolic acidosis was detected in 8 cases, proteinuria and hematuria was found in 8 and 5 cases consecutively. The results of treatment were not fully satisfactory. Four out of 5 cases who underwent intermittent peritoneal dialysis died. Based on clinical proJile, prevalence, age distribution and outcome of the disease with relatively high mortality we come to the conclusion that our cases were class

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ed as atypic or. sporadic type, strictly different from cases reportedfrom the literature such as Argentina or Northern part of India which usually present the clinical profile of epidemic type with a better prognosis.