Ad J.M. Hendrikx

Long-term quality of life among Dutch prostate cancer survivors: Results of a population-based study

In this report, the authors describe the health‐related quality of life (HRQL) of long‐term prostate cancer survivors 5 to 10 years after diagnosis and compare it with the HRQL of an age‐matched, normative sample of the general Dutch population.

Transrectal ultrasound in the diagnosis of prostate cancer: state of the art and perspectives.

Objectives: Transrectal ultrasound (TRUS) is an important tool in diagnosing prostate cancer. However, specificity and sensitivity of conventional grey–scale TRUS for the detection of prostate cancer are disappointingly low. New ultrasound modalities are designed to overcome the disappointing results and improve the use of ultrasound in the diagnosis of prostate cancer. This work is a review of the recent literature, combined with own experiences. Methods: The papers were collected using a Medline search, combined with some papers by author selection. The terms used for the Medline search included among other things: transrectal ultrasound, prostate, prostate cancer, prostate biopsies, colour Doppler ultrasound, power Doppler ultrasound, contrast ultrasound. The authors used their own experiences for illustrations of various techniques. Results and Conclusions: Although several modalities show a significant improvement in sensitivity and specificity for the detection of prostate cancer, none of the TRUS modalities discussed can replace prostate biopsies as a definitive diagnostic. Several techniques, especially contrast ultrasound, show definitive promise. However, two valid conclusions can be made from the data presented. First: with today’s technology, none of the TRUS modalities discussed can replace systemic biopsies in the early detection of prostate cancer. Second: none of the discussed TRUS modalities has found a definitive place in routine clinical practice.

The value of antibiotic prophylaxis during extracorporeal shock wave lithotripsy in the prevention of urinary tract infections in Patients with urine proven sterile prior to treatment

There are controversies in the literature regarding the need for and duration of antibiotic prophylaxis in patients treated with extracorporeal shock wave lithotripsy (ESWL) who have a negative urine culture before treatment. In order to determine the efficacy of antibiotic prophylaxis in ESWL treatment of patients with proven sterile urine, a randomized trial was performed. Patients were randomized for placebo and 1 or 7 days antibiotic prophylaxis (cefuroxime or ciprofloxacin), starting 30 min before ESWL. Post-ESWL studies (immediately and 2 and 6 weeks after ESWL) included patient history, urine culture and Gram stain. After 2 weeks 20% of the patients and after 6 weeks 23% of the patients had bacteriuria, but there was no statistical significance between patients treated with placebo or those receiving prophylactic treatment. Only 2-3% of the patients (in the prophylaxis and placebo group) had clinical and bacteriological signs of a urinary tract infection, either 2 or 6 weeks after ESWL, possibly caused by re-infection, however, since bacteria were found in none of the urine samples collected directly after ESWL. There was no beneficial effect of antibiotic prophylaxis, in the prevention of urinary tract infections in patients with a nephrostomy catheter or dilatation at the site of treatment. We conclude that in patients with urine proven sterile prior to ESWL there is no need for antibiotic prophylaxis

How Useful and Realistic is the Uro Trainer for Training Transurethral Prostate and Bladder Tumor Resection Procedures

PURPOSE We evaluated the face and content validity (novice and expert opinions of realism and usefulness) of the Uro Trainer (Karl Storz GmbH, Tuttlingen, Germany), a simulator for transurethral resection procedures, to ascertain whether it is justifiable to continue the validation process by performing prospective experimental studies. MATERIALS AND METHODS Between 2006 and 2008, 104 urologists and urology residents performed a transurethral bladder tumor resection and/or transurethral prostate resection procedure on the Uro Trainer, and rated simulator usefulness and realism on a 10-point scale (1-not at all useful/realistic/poor, 10-very useful/realistic/excellent). Participants were classified as experts (more than 50 procedures performed) or novices (50 or fewer procedures performed). Because the literature offered no guidelines for interpreting our data, we used criteria from other studies to interpret the results. RESULTS A total of 161 questionnaires were analyzed from 97 (21% experts, 79% novices) and 64 (30% experts, 70% novices) participants who performed transurethral prostate resection and transurethral bladder tumor resection procedures, respectively. Mean usefulness, realism and overall scores varied from 5.6 to 8.2 (SD 1.4-2.5). Measured by validity criteria from other studies, Uro Trainer face and content validity was unsatisfactory, with ratings on only 3%, 5% and 8% of the parameters interpreted as positive, moderately acceptable and good, respectively. CONCLUSIONS Measured against criteria from other validation studies, Uro Trainer face and content validity appears to be unsatisfactory. Modification of the simulator seems advisable before further experimental validation studies are initiated. The lack of general guidelines for establishing face and content validity suggests a need for consensus about appropriate methods for evaluating the validity of simulators.

Transfer of cysto-urethroscopy skills from a virtual-reality simulator to the operating room: a randomized controlled trial

Study Type – Therapy (RCT)
 Level of Evidence 1b

Program for laparoscopic urologic skills: a newly developed and validated educational program.

OBJECTIVE To develop and evaluate a program for laparoscopic urologic skills (PLUS) to determine the face, content, and construct validation to achieve uniformity and standardization in training residents in urology. METHODS The PLUS consists of 5 basic laparoscopic tasks. Three tasks were abstracted from the Fundamentals of Laparoscopic Surgery program, and 2 additional tasks were developed under continuous evaluation by expert urologists. Fifty participants were recruited from different hospitals and performed the final PLUS training. They all completed a questionnaire after performance. Three outcome parameters were measured: performance quality, time, and dropped objects. The relationship between laparoscopic experience and the outcome parameters was investigated. RESULTS Of the 50 participants, 13 were students, 20 were residents, and 17 were urologists. Double-log linear regression analysis for all 5 tasks showed a significant effect (effect size range 0.53-0.82; P < .0005) for laparoscopic experience on performance time. Substantial correlations were found between experience and quality ratings (log-linear regression effect size 0.37; P = .012) and the number of dropped objects (Spearman correlation effect size 0.49; P < .01). The usefulness of the PLUS model as a training tool for basic laparoscopic skills was rated 4.55 on a scale from 1 (not useful) to 5 (useful) (standard deviation 0.58; range 3-5). CONCLUSION The results of the present study indicated the face, content, and construct validity for the PLUS. The training is considered appropriate for use as a primary training tool for an entry test or as part of a step-wise training program in which basic and procedural laparoscopic skills are integrated.

A Comparison of the Physical Properties of Four New Generation Flexible Ureteroscopes: (De)Flection, Flow Properties, Torsion Stiffness, and Optical Characteristics

BACKGROUND AND PURPOSE Several kinds of flexible ureteroscopes are in use for the removal of kidney stones. This study evaluated and compared the characteristics of four new-generation flexible ureteroscopes. MATERIALS AND METHODS The flexible ureteroscopes studied were: the ACMI Dur-8 Elite, the Storz Flex-X2 the Olympus XURF-P5, and the Wolf 7325.076. Measured properties included (de)flection, instrument insertion, flow properties, torsion stiffness, and optical characteristics. Active tip deflection and irrigation flow rates with and without various endoscopic tools were assessed. RESULTS All ureteroscopes score better on (de)flection with an empty working channel, compared with a channel when tools are inserted (differences minimum 0.3 degrees--maximum 80.6 degrees). The Olympus XURF-P5 is the only ureteroscope with passive (de)flection capability, whereas the ACMI DUR-8 Elite is the only ureteroscope that has a secondary active (de)flection capability. The Storz Flex-X2 and the Wolf 7325.076 ureteroscopes show nearly identical best deflection capabilities with and without tools inserted in the working channel. The longest (Olympus XURF-P5, 70 cm) and shortest (ACMI DUR-8 Elite, 64 cm) ureteroscopes have, respectively, the lowest and highest flow rates. Best optical quality is offered by the Olympus XURF-P5 and Wolf 7325.076 ureteroscopes, which have low optical distortion (-9.7; -7.7%), high resolving power (17.95; 16.00 line pairs per millimeter), and a large field of view (62.9; 63.2 degrees). The Storz Flex-X2 and Wolf 7325.076 ureteroscopes have lowest torsion stiffness. CONCLUSIONS The ex vivo evaluation of the deflection capabilities, passage of instruments, flow properties, torsion stiffness, and optical characteristics yielded quantitative measures of the in vivo performance capabilities of four new-generation flexible ureteroscopes. New ureteroscopes should be subjected to this or similar evaluation and comparison. Only in this way can the urologist make an informed and objective decision regarding appropriate instrument choice.

Acquisition of flexible cystoscopy skills on a virtual reality simulator by experts and novices

Study Type – Therapy (case control)
Level of Evidence 3b

The Virtual Reality Endourologic Simulator Is Realistic and Useful for Educational Purposes

PURPOSE To examine the educational value of URO Mentor, a virtual reality simulator for endourologic procedures, by establishing its face and content validity. MATERIALS AND METHODS Eighty-nine urologists and residents in urology performed a urethrocystoscopy task (bladder inspection, biopsy, and coagulation) or a ureterorenoscopy task (manipulation of a distal ureter stone) using the URO Mentor. They completed an evaluation questionnaire about these tasks. Questionnaire bias related to task performance on URO Mentor was analyzed as well (Hawthorne effect). RESULTS The overall rating of the URO Mentor was 7.3 on a 10-point scale (1 = poor, 10 = excellent). Regression analysis showed that ratings were not related to previous experience or task performance using the URO Mentor. Of all subjects, 25% rated the realism of URO Mentor as >or=3.5 on a five-point scale, and 82% rated its usefulness as an educational tool as >or=3.5 on a five-point scale. More than 73% of all participants said they would purchase a URO Mentor if financial means were available; participants who needed more time to complete the task were less positive in their answers to this question. CONCLUSIONS URO Mentor appears to be a realistic and useful training model for endourologic procedures.

Designing simulator-based training: An approach integrating cognitive task analysis and four-component instructional design

Most studies of simulator-based surgical skills training have focused on the acquisition of psychomotor skills, but surgical procedures are complex tasks requiring both psychomotor and cognitive skills. As skills training is modelled on expert performance consisting partly of unconscious automatic processes that experts are not always able to explicate, simulator developers should collaborate with educational experts and physicians in developing efficient and effective training programmes. This article presents an approach to designing simulator-based skill training comprising cognitive task analysis integrated with instructional design according to the four-component/instructional design model. This theory-driven approach is illustrated by a description of how it was used in the development of simulator-based training for the nephrostomy procedure.