Adam Borzęcki

Darier-White disease treated with fractional CO2 laser in two cases.

Darier–White disease is one of the most common genodermatoses. The most typical clinical symptoms such as diffuse hyperkeratotic papulae usually appear during puberty or early adulthood in seborrhoeic area. It is connected with substantial deterioration of the quality of life due to aesthetic defect. Although there exist many therapeutic options, the disease still causes considerable therapeutic difficulties. Treatment with fractional CO2 laser seems to be a promising therapeutic method. In this paper, we present two cases of patients with Dariers disease who have been treated with a fractional CO2 laser with very good clinical outcome.

Skin melanoma imaging using ultrasonography: a literature review

Melanoma is one of the most unpredictable tumours, as regards both morphology and the course of disease. It may have different clinical forms making it very difficult to diagnose. Therefore, it often surprises even the most experienced dermatologists. Despite numerous attempts, no efficient treatment of advanced stages have been elaborated, and early detection and removal of a skin lesion currently constitutes the most efficient treatment method. Diagnostics uses different types of dermoscopic techniques characterised by considerable sensitivity and specificity in detecting melanoma at an early developmental stage. A continuous development of medical technologies leads to improving many methods of skin lesion imaging. Ultrasonography is one of these methods, enabling evaluation of the thickness of melanoma in vivo with high precision. Change thickness is the decisive factor influencing 5-year survival. The paper evaluates the usefulness of high-frequency ultrasonography (HFUS) in pre-operative melanoma imaging on the basis of literature review. Additionally, the use, role and placement of HFUS in skin melanoma diagnostics is determined.

A rare case of solitary trichoepithelioma treated with carbon dioxide laser

Trichoepithelioma (TE) is a benign skin neoplasm derived from the hair follicle. It is commonly located on the face and hairy skin. Malignant transformation is quite rare. TE affects adults and more frequently women. The most common presentations are noted in the 4th decade [1]. There are three variants of TE: solitary TE, multiple TE and desmoplastic TE [2-4]. The solitary TE is non-familial. The multiple TE is familial. The gene for the development of familial trichoepithelioma encodes of chromosome 9 [5]. We report a rare and interesting case of solitary trichoepithelioma (sTE) treated with carbon dioxide laser.

Combination therapy of basal-cell carcinoma in 31-year-old patient with nevoid basal cell carcinoma syndrome – Case study

Nevoid basal cell carcinoma syndrome (NBCCS) is a rare genetic disease that is manifested in a number of disorders concerning the skin, skeleton, cardiovascular and nervous systems. Various defects which can be observed at first contact with a patient visiting a dermatologist or dentist may help to diagnose this syndrome. Frequent problems with odontogenic cysts and metastatic basal-cell carcinomas result in patients being under the constant care of a specialist. This short study presents the case of 31-year-old patient with Gorlin-Goltz syndrome treated with combination therapy using CO2 laser and photodynamic therapy.

Linear verrucous epidermal nevi—effects of carbon dioxide laser therapy

Linear epidermal nevus is a congenital malformation characterized by linear, often one-sided arrangement. The lesions are localized along the Blaschkos lines, are present at birth, or appear in early childhood. They can be single or multiple, and have various colors–from skin color to dark brown. These lesions persist through the whole life making a significant cosmetic defect. Here, we present three clinical cases of epidermal nevus treated with CO2 laser. In a female patient, verrucous, dark brown skin eruptions were observed at the back of earlobe and down the neck. In the cases of the male patients, the lesions were located in the area of the neck and left blade. The removal of nevi was performed in stages, by cutting and evaporation using a CO2 laser. A very good therapeutic effect was obtained. CO2 laser treatment is the method of choice for the removal of extensive epidermal nevi. It is characterized by high efficacy and safety.

Extensive Bowen’s disease of the face – combined therapy

Introduction. The most commonly diagnosed cancer group in humans is cancers of the skin. One pre-invasive form of squamous cell carcinoma is Bowens disease. It manifests in the form of single or multiple lesions, which may be located on the skin of any part of the body. Most often it appears in the form of a well-demarcated, oval patch covered with a small crust. Risk factors are immunosuppression, exposure to arsenic, HPV viruses, solar radiation and X-rays. Objective. Presentation of a case of extensive Bowen’s disease, in which combined therapy methods had to be used. Case report. In this paper we present a case of extensive Bowens disease of the face in an 86-year-old female patient. Due to the difficult location and a large lesion, the combined therapy was used: CO2 laser, photodynamic therapy and imiquimod. Satisfactory results were achieved. Conclusions. In extensive Bowen’s disease in order to remove it and achieve a satisfactory cosmetic effect, combined therapy may be necessary. SŁOWA KLUCZOWE: choroba Bowena, leczenie skojarzone, laser CO2, terapia fotodynamiczna.