Adam Wolfberg

Obstetric and neonatal outcomes associated with maternal hypothyroid disease.

Objective: We sought to determine whether women with treated hypothyroid disease were more likely than women without thyroid disease to suffer adverse obstetric or neonatal outcomes or to deliver a child with a congenital anomaly. Methods: Using an institutional database, we identified women with treated hypothyroid disease (nu200a=u200a482) who delivered a baby at our institution during a 33-month period. We compared the occurrence of adverse obstetric or neonatal outcomes among these women to the occurrence among women without thyroid disease (nu200a=u200a19,487). Results: Women with treated hypothyroid disease were not at increased risk for delivering a baby with low birth- weight, fetal demise, or congenital anomaly compared to the control group. Women with treated hypothyroid disease were more likely to have chronic hypertension (2.3% vs. 1.2%, pu200a=u200a0.03) and had an increased risk of pre-eclampsia (4.3% vs. 2.6%, pu200a=u200a0.03) compared to women without thyroid disease. Conclusion: Women with treated hypothyroid disease are not at higher risk than the general population for adverse neonatal outcomes, but may be at increased risk for pre-eclampsia.