Adelaide S. Robb
Duke University
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Journal of the American Academy of Child and Adolescent Psychiatry | 2008
W. Burleson Daviss; Nick C. Patel; Adelaide S. Robb; Michael P. McDermott; Oscar G. Bukstein; William E. Pelham; Donna Palumbo; Peter C. Harris; Floyd R. Sallee
OBJECTIVE To examine the safety and tolerability of clonidine used alone or with methylphenidate in children with attention-deficit/hyperactivity disorder (ADHD). METHOD In a 16-week multicenter, double-blind trial, 122 children with ADHD were randomly assigned to clonidine (n = 31), methylphenidate (n = 29), clonidine and methylphenidate (n = 32), or placebo (n = 30). Doses were flexibly titrated up to 0.6 mg/day for clonidine and 60 mg/day for methylphenidate (both with divided dosing). Groups were compared regarding adverse events and changes from baseline to week 16 in electrocardiograms and vital signs. RESULTS There were more incidents of bradycardia in subjects treated with clonidine compared with those not treated with clonidine (17.5% versus 3.4%; p =.02), but no other significant group differences regarding electrocardiogram and other cardiovascular outcomes. There were no suggestions of interactions between clonidine and methylphenidate regarding cardiovascular outcomes. Moderate or severe adverse events were more common in subjects on clonidine (79.4% versus 49.2%; p =.0006) but not associated with higher rates of early study withdrawal. Drowsiness was common on clonidine, but generally resolved by 6 to 8 weeks. CONCLUSIONS Clonidine, used alone or with methylphenidate, appears safe and well tolerated in childhood ADHD. Physicians prescribing clonidine should monitor for bradycardia and advise patients about the high likelihood of initial drowsiness.
Journal of the American Academy of Child and Adolescent Psychiatry | 2016
Robert L. Findling; Adelaide S. Robb; Melissa P. DelBello; Michael Huss; Nora K. McNamara; Elias H. Sarkis; Russell E. Scheffer; Lis H. Poulsen; Grace Chen; Ole Lemming; Philippe Auby
Journal of the American Academy of Child and Adolescent Psychiatry | 2018
Adelaide S. Robb
Journal of the American Academy of Child and Adolescent Psychiatry | 2018
Gerrit I. van Schalkwyk; Adelaide S. Robb
Journal of the American Academy of Child and Adolescent Psychiatry | 2018
Adelaide S. Robb
Journal of the American Academy of Child and Adolescent Psychiatry | 2018
Pamela Campbell; Adelaide S. Robb
Journal of the American Academy of Child and Adolescent Psychiatry | 2018
Timothy E. Wilens; Adelaide S. Robb
Journal of the American Academy of Child and Adolescent Psychiatry | 2018
Adelaide S. Robb; Timothy E. Wilens; Elias H. Sarkis
Journal of the American Academy of Child and Adolescent Psychiatry | 2017
Adelaide S. Robb
Journal of the American Academy of Child and Adolescent Psychiatry | 2017
Timothy E. Wilens; Adelaide S. Robb; Robert L. Findling