Adetunji J. Aladesanmi

Two carbazole alkaloids from Murraya koenigii

Abstract The non-cyclized possible biogenetic precursors of girinimbine and mahanimbine, 2-hydroxyl-3-methyl-1-(3-methyl-2-butenyl)carbazole (girinimbilol) and 2-hydroxyl-3-methyl-1-(3,7-dimethyl-2,6-octadienyl)carbazole (mahanimbilol) have been isolated from the stem bark of Murraya koenigii. The structures were established by cyclization to dihydrogirinimbine and a new bicyclocarbazole, bicyclomahanimbiline, respectively.

Lenticellarine, a molluscicidal alkaloid from Dysoxylum lenticellare

Abstract A new, homoerythrina-derived alkaloid with molluscicidal activity, lenticellarine, was isolated from the leaves of Dysoxylum lenticellare and its structure was determined by spectroscopic methods.

A biflavonoid from Dysoxylum lenticellare gillespie

Abstract A novel biflavonoid, robustaflavone 4′,7″-dimethyl ether, has been isolated from the leaves of Dysoxylum lenticellare , in addition to two known compounds, isoginkgetin and bilobetin. Their structures were established by spectroscopic data and chemical modification.

The stem constituents of dysoxylum lenticellare

Abstract A total of nine compounds have been isolated from the stem of Dysoxylum lenticellare Gillespie (Meliaceae). They are the five homoerythrina-type alkaloids ( 1 , 2 , 6 , 7 , 9 ), of which 1 and 2 are new. Three diterpenes ( 3 - 5 ) while ( 3 ) is a new compound, compound ( 8 ) is well known. The nine compounds were characterized by the spectroscopic analysis.

Additional alkaloids from the stem of Dysoxylum lenticellare

Abstract 2-α-Methoxycomosivine and two presumed homoerythrina-derived alkaloids, 2α-methoxylenticellarine and 2α-hydroxylenticellarine, have been isolated from the stem of Dysoxylum lenticellare . The three alkaloids have been identified by comparison of their spectroscopic properties.

Evaluation of Ethnomedical Claim III: Anti-hyperglycemic activities of Gongronema latifolium root and stem (民族药物需求评估III：Gongronema latifolium根与茎的降糖活性)

The insulinotropic activity of the combined root and stem of Gongronema latifolium (Asclepiadaceae) was evaluated to justify its African ethnomedicinal use in the management of diabetes.

Evaluation of ethnomedical claim III: anti-hyperglycemic activities of Gongronema latifolium root and stem.

The insulinotropic activity of the combined root and stem of Gongronema latifolium (Asclepiadaceae) was evaluated to justify its African ethnomedicinal use in the management of diabetes.

Ferrubietolide: X-ray crystal structure of a novel bis-diterpene from Dysoxylum Ienticellare

Spectroscopic and X-ray diffraction analyses have established the structure and stereochemistry of ferrubietolide, a new bis-diterpene isolated from Dysoxylum Ienticellare, which apparently arises as the result of a Diels–Alder condensation of two dissimilar diterpenes.

Evaluation of Ethnomedical Claims II: Antimalarial Activities of Gongronema latifolium Root and Stem

Methanolic extract and chromatographic fractions of Gongronema latifolium were tested against clinical isolates of Plasmodium falciparum-, P. yoelii nigeriensis-infected mice, chloroquine-sensitive (D6) and chloroquine-resistant (W2) P. falciparum clones. The isolates, characterized as a 1:1 mixture of α-amyrin and β-amyrin cinnamates (1a/1b), lupenyl cinnamate (2) and lupenyl acetate (3), were assayed using the clones. Extract, most active vacuum liquid and column chromatographic fractions had respective ED50 values of 120.85, 32.03, 25.62 mg.kg-1 and IC50 of 36.27, 9.45, 7.05 μg.mL-1, against W2 clones. Lupenyl acetate had 18.96 μg.mL-1, indicating synergistic action of the constituents. Results justified its ethnomedical use for treating malaria.

Evaluation of Ethnomedical Claim III: Anti-hyperglycemic activities ofGongronema latifoliumroot and stem (民族药物需求评估III：Gongronema latifolium根与茎的降糖活性): Antidiabetic constituents ofUtazi

The insulinotropic activity of the combined root and stem of Gongronema latifolium (Asclepiadaceae) was evaluated to justify its African ethnomedicinal use in the management of diabetes.