Adnan Bulut

Catalytic Asymmetric Nitroaldol (Henry) Reaction with a Zinc-Fam Catalyst

Ferrocenyl-substituted aziridinylmethanol (Fam-1) was used as a catalyst with zinc for the asymmetric nitroaldol (Henry) reaction. This catalyst worked with a variety of aldehydes (aromatic, aliphatic, alpha,beta-unsaturated, and heteroaromatic) and alpha-ketoesters to give the nitroaldol product in up to 97% yield and 91% ee. The chiral ligand can be recovered and recycled without losing its activity.

Synthesis of New Ferrocenyl‐Substituted Aziridines via the Gabriel–Cromwell Reaction

Abstract The Gabriel–Cromwell method is applied successfully in the synthesis of ferrocenyl‐substituted aziridines. Acryloyl‐ and crotonoylferrocenes are brominated first and then reacted with benzylamine, diisopropylamine, and furfurylamine in the presence of triethylamine. The aziridines are obtained in more than 90% isolated yields.

Synthesis and biological activity of ferrocenyl furoyl derivatives

ABSTRACT Due to the fact that ferrocene and furan derivatives have long been known to be one of the most biologically active compounds, preparation of their new derivatives might serve a very important purpose. Herein, five furoyl ferrocenes were synthesized via EAS reaction utilizing AlCl3-EtAlCl2 Lewis acids. The compounds 1–5 were obtained in moderate yields and characterized by IR, 1H-NMR, 13C-NMR, and mass spectrometry. Although toxicity increases with concentration, at 100 µg/mL concentration, the protection of cell viability was observed to be 70% level. At 50 µg/mL concentration, apoptosis in cancer cells observed was 63 ± 4% leading to high apoptosis ratio for the compound 3. For the compounds (1–5), the necrotic effects were found to be between 21% and 39% at 50 µg/mL concentration.

Crystal structure of dimethylammonium bis(naphthalene-2,3-diolato)borate, C22H20BNO4

Abstract C22H20BNO4, monoclinic, C2/c (no. 15), a = 32.303(4) Å, b = 8.2703(6) Å, c = 7.3876(6) Å, β = 92.889(8)°, V = 1971.1(3) Å3, Z = 4, Rgt(F) = 0.0978, wRref(F2) = 0.2063, T = 298 K.

1,4-Diferrocenylbutane-1,4-dione

In the crystal structure of the title compound, [Fe2(C5H5)2(C14H12O2)], each carbonyl group is coplanar with the adjacent cyclopentadienyl ring, thus maximizing the π-orbital overlap and electronic interactions between the groups. In the crystal structure, there are inter- and intramolecular C—H⋯O contacts.