Adriana Leis

NORMATIVE DATA OF THE ARGENTINE VERSION OF THE SIGNORET BATTERY FOR MNESIC EFFICIENCY (BEM144) AND DISCRIMINATIVE VALIDITY FOR MILD COGNITIVE IMPAIRMENT

condition and AVLT-LTM (p1⁄40.02, r1⁄4-0.50). Combining two UEF parameters in regression models for predicting AVLT scores, we observed a significant association between UEF models with AVLT-STM and AVLT-LTM scores for both normal and rapid tasks (p<0.02, r1⁄40.53-0.71). Conclusions: In cognitively normal older adults, the UEF normal and rapid elbow flexion speed significantly correlated with the AVLT STM and AVLT LTM while UEF motion variability in the normal speed condition correlated with AVLT LTM, suggesting a potential role for UEF tasks in enhancing assessment of early cognitive decline. Further research on the role of UEF as a rapid screen for early cognitive impairment is recommended.

RAPIDLY PROGRESSIVE DEMENTIAS: ETIOLOGIES FOUND IN A HIGH COMPLEXITY REFERRAL CENTER IN BUENOS AIRES

P2-312 RAPIDLY PROGRESSIVE DEMENTIAS: ETIOLOGIES FOUND IN A HIGH COMPLEXITY REFERRAL CENTER IN BUENOS AIRES Gustavo Andres Da Prat de Magalhaes, Galeno Rojas, Adriana Leis, Martin Cesarini, Jose Luis Etcheverry, Maria Pilar Sanchez, Maria Bres Bullrich, Natalia Gonzalez Rojas, Virginia Laura Parisi, Gabriel Gustavo Persi, Emilia Gatto, Sanatorio Trinidad Mitre, Buenos Aires, Argentina; Sanatorio de la Trinidad Mitre, Unidad de Neurociencias, Caba, Argentina; Sanatorio de la Trinidad Mitre, Buenos Aires, Argentina; INEBA, Buenos Aires, Argentina. Contact e-mail: gustavoda_prat@hotmail.com

PREDICTORS OF CHANGE IN QUALITY OF LIFE IN PATIENTS WITH FOCAL NEUROLOGICAL DAMAGE FOLLOWING AN OUTPATIENT COGNITIVE REHABILITATION PROGRAM

OBJECTIVE: To evaluate the independent predictors of Quality of Life (QoL) change in patients with Focal Neurological Damage (FND) following an Outpatient Cognitive Rehabilitation (OCR) program. BACKGROUND: Few studies have analyzed the clinical and cognitive features associated with better outcomes in patients following an OCR program. DESIGN/METHODS: 90 patients (33 female, age: (mean ± SD) 51.27±19.68 years; education 14.51±3.37 years; Mini-Mental State Examination initial score 26.16±3.44) with cognitive impairment secondary to FND (60 cases with history of stroke, 22 cases of traumatic brain injury, 8 cases of other FND etiologies) were included. The subjects completed cognitive-behavioral, functional and social scales at baseline and treatment end. Efficacy, as measured by changes in the World Health Organization Quality of Life Brief Evaluation Instrument (WHOQOL-BREF), was evaluated by dividing the sample into 3 groups: benefit (difference >5 %), stability (difference between 5% and -5%), and worsening (difference >-5%). Categorical and quantitative predictors at baseline were analyzed prospectively. RESULTS: Based on the changes in the WHOQOL-BREF scale, 29 patients (32.2%) showed benefit, 45 (50%) showed stability, and 16 (17.8%) worsened after the OCR program. The predictors associated with benefit were: small number of sessions (p<0.05), lower score in the analogical visual scale (p<0.01), and poor score in the California Verbal Learning Test (CVLT) (p<0.05) and in direct span (p<0.01). The predictors associated with stability were: a better performance in the CVLT (p<0.01) and in direct span (p<0.01), and higher patient`s subjective memory score evaluated by the caregiver (p<0.01). The group that showed a worsening in QoL was associated to a higher Beck depression inventory score at baseline (p<0.01). CONCLUSIONS: In patients with FND following an OCR program, the analysis of independent predictors of QoL change may allow for a better prediction of treatment response. Study Supported by: Disclosure: Dr. Rojas has nothing to disclose. Dr. Leis has nothing to disclose. Dr. Ciufia has nothing to disclose. Dr. Saux has nothing to disclose. Dr. Feldberg has nothing to disclose. Dr. Caceres has received personal compensation for activities with Abbott, Serono Inc., and Teva Neuroscience as a speaker. Dr. Demey has nothing to disclose.