Adrianna Milagres

Carcinoma adenóide cístico: revisão da literatura e relato de caso clínico

The adenoid cystic carcinoma (ACC) is a malignant neoplasm of salivary gland that arises preferencially in parotid glands, submandibular and minor salivary glands, but is uncommon in sublingual glands. The ACC is a slow growth and infiltrative tumour that clinically is characterized by a firm mass. The present study aims to rewiew the atually literature of the ACC in relation of clinical and histopathological features and describes a case of ACC in submandibular gland.

Contribuição da citopatologia para o diagnóstico de carcinoma de células escamosas oral

A incidencia de câncer tem aumentado significativamente em todo o mundo, configurando-se como um dos mais importantes problemas de saude publica. Como consequencia o câncer de boca tambem tem aumentado, com 94% dos casos correspondendo ao carcinoma de celulas escamosas. O objetivo deste estudo foi atualizar o tema e documentar a experiencia de cinco anos na utilizacao da citopatologia para avaliacao de lesoes orais suspeitas de malignidade. Realizou-se uma busca no arquivo do Servico de Anatomia Patologica do Hospital Universitario Antonio Pedro da Universidade Federal Fluminense (HUAP/UFF), referente ao periodo de 2002 a 2007, de pacientes com lesoes orais clinicamente suspeitas de carcinomas submetidos simultaneamente a biopsia incisional e a raspados da lesao para analise citopatologica. A amostra selecionada correspondeu a 50 casos, mas em 41 (82%) pacientes, o diagnostico histopatologico foi de carcinoma de celulas escamosas. Desses, a citopatologia foi conclusiva em 30 (73%) e descreveu alteracoes suspeitas em 11 (27%) pacientes. Os resultados revelaram que a citopatologia apresentou concordância diagnostica de 74% com a histopatologia (padrao-ouro) nos diagnosticos positivos para carcinoma de celulas escamosas, e negativos para malignidade. Os resultados obtidos indicam a necessidade de padronizacao da tecnica e da avaliacao de grandes casuisticas para definicao da acuracia, pois, na casuistica avaliada, a citopatologia apresentou-se como um metodo fidedigno, que podera ser utilizado como recurso de diagnostico suficiente para o imediato encaminhamento dos pacientes para o tratamento de carcinoma de celulas escamosas oral.

Estudo comparativo de raspados orais submetidos à técnica de citologia em meio líquido e citopatologia convencional

INTRODUCTION: When compared to conventional cytopathology (CC), liquid-based cytology (LBC) has been referred to as a method of superior performance in cervical smears. OBJECTIVE: To quantitatively and qualitatively compare oral smears obtained through conventional cytopathology and liquid medium cytology. MATERIAL AND METHODS: Six individuals with normal oral mucosa had the lateral border of their tongues scraped. Three collecting instruments were tested in this process: endocervical brush (cytobrush), a plastic spatula, and the LBC kit brush. Both methods, CC and LBC, were applied. Results: The endocervical brush was the most appropriate collecting instrument; as far as method is concerned, liquid medium cytology provided slides with more regular and homogeneous cellular distribution in comparison to conventional cytopathology. There was also a reduction in the number of inflammatory cells and bacteria colonies. DISCUSSION: Cellular overlapping was not totally eliminated in the liquid medium cytology as reported in medical literature, inasmuch as it was present in some slides, though in a smaller amount. Although in cervical samples the reduction of inflammatory cells, erythrocytes and mucus is considered an advantage of LBC, in oral smears these elements may represent significant aspects of some oral diseases. CONCLUSIONS: Liquid-based cytology may be an additional technique to be used with complementary exams in oral diagnosis, but despite the fact it presents some favorable results some adaptations are still necessary for its use in oral diagnosis.