Agabus N. Manasseh

Changing patterns of Kaposi's sarcoma in Nigerians:

This is a five-year retrospective study of 32 histologically diagnosed cases of Kaposis sarcoma (KS) who had undergone HIV antibody testing at the Jos University Teaching Hospital: 13 cases (40%) were HIV-negative. Multiple lesions were more common in HIV-positive cases and affected unusual sites such as the face, oropharynx, conjuctiva, vulva and rectum in addition to the limbs and trunk, which were more frequently involved in HIV-negative cases. This pattern of KS seen in Nigerian patients shows similarities with other African countries which have been affected by the HIV epidemic.

Hepatic histopathological findings in HIV patients at postmortem in Jos university teaching hospital, Nigeria

Multi-organ involvement by opportunistic infections and neoplasms is the major cause of morbidity and mortality in people living with HIV/AIDS. We determined the spectrum/frequency of hepatic histopathological lesions in a prospective study of postmortem liver biopsies from 100 patients (50 females and 50 males, age range 18-55 years) who died from HIV/AIDS in Jos university teaching hospital, Nigeria. The majority of the patients, 65 (65%), had clinical tuberculosis. Granulomatous hepatitis, chronic hepatitis, non-specific reactive hepatitis (NSRH) and steatosis were the commonest hepatic histopathologic lesions occurring in 34, 20,15 and 12% of patients, respectively. Seven (7%) had normal histological features. This study shows that the liver is affected in HIV/AIDS as reported elsewhere in the world. Therefore, liver biopsy in HIV patients may be helpful in the management of these patients.

Persistent alveolar soft-part sarcoma with liver metastasis: a case report

IntroductionAlveolar soft-part sarcomas are rare, slow-growing tumors that metastasize commonly via vascular routes to the lungs, bones, lymph nodes and brain, causing morbidity and mortality. To the best of our knowledge, this is the first case describing metastasis to the liver reported from Nigeria.Case presentationA 57-year-old man of the Urhobo ethnic group of Nigeria presented with a persistent mass in his left calf. It was initially diagnosed as soft-tissue sarcoma, and its associated systemic effects lead to his death before a histological diagnosis could be obtained.ConclusionsAlveolar soft-part sarcoma with metastasis to the liver can occur in our region (northeast Africa), and a high index of suspicion is required to make an early diagnosis, followed by prompt surgical excision with clear margins in order to prevent mortality.

The role of necropsy in diagnostic dilemmas as seen in a tertiary hospital in north central Nigeria.

Background. Necropsy (autopsy) has helped medical science and law. It has given rise to numerous diagnostic surprises as it explains cause of death, pathogenesis of diseases, and circumstances of death. It also explains reasons for most therapeutic failures. In spite of its usefulness, the rate has dropped worldwide and Africa is worse hit. This work aims to highlight the role autopsy (Necropsy) plays in demystifying diagnostic dilemmas and to encourage its patronage by medical practitioners, law enforcement agents and society. Methods. This is a retrospective review of autopsy and clinical reports of cases seen by pathologists and physicians in the Jos University Teaching Hospital (JUTH), Jos, North central Nigeria. Results. A total 166 cases were studied out of which 52 had same diagnosis for both attending physician and pathologist, 106 had different diagnoses and in eight cases diagnoses remained unknown even after autopsy was performed. Conclusions. Autopsy remains an important tool for obtaining definitive diagnosis, determining cause of death to explain pathogenesis of diseases, medical auditing and a vital source of data for health statistics and planning.

HIV/TB Co-infection: Liver Biopsy Findings

Abstract Background: Human immunodeficiency virus and tuberculosis (HIV/TB) co-infection in an individual constitutes a serious diagnostic and therapeutic challenge. Objective: To determine liver pathology in patients with HIV and TB co-infection. Methods: Postmortem liver biopsy was done on patients with HIV/TB co-infection. The tissues were subjected to routine histological processing. The sections were stained with haematoxylin and eosin, including special stains. Results: Sixty-seven biopsies from 67 patients (33 men and 34 women) were analysed. Thirty-nine (58.2%) had pulmonary tuberculosis (PTB) while 26 (38.8%) had disseminated tuberculosis (DTB). Two (3%) had tuberculous meningitis (TBM). Fourteen (36%) patients with PTB, 10 (38%) with DTB and one (50%) with TBM had hepatic granuloma with caseation. Histologically granuloma 25 (37.4%), chronic hepatitis 13 (19.4%), nonspecific reactive hepatitis (NSRH) 11(16.4%), steatosis nine (13.4%) and cirrhosis seven (10.4%) were found. Conclusion: This study...

Erratum to: Outcome of HIV-associated lymphoma in a resource-limited setting of Jos, Nigeria

[This corrects the article DOI: 10.1186/s13027-017-0144-7.].