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Dive into the research topics where Agnès Daurat is active.

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Featured researches published by Agnès Daurat.


Physiology & Behavior | 1993

Bright light affects alertness and performance rhythms during a 24-h constant routine.

Agnès Daurat; Acacia Aguirre; Jean Foret; Philippe Gonnet; Anne Keromes; Odile Benoit

The aim of the present study was to assess the stimulating effects of bright light (BL) on subjective and objective alertness. Eight subjects were exposed to either bright light or dim light (DL) during a 24-h constant routine (0900-0900). Bright light failed to modify either the 24-h course or the level of body temperature. Compared to DL, BL delayed the circadian trough of motor activity by 2 h. During the night, relative to the dim-light condition, BL significantly increased subjective and objective (EEG test) alertness and improved performances. Thus, BL exposure partly counteracted the effects of sleep deprivation and/or the circadian trough on alertness and performances. During the day, BL only improved the mood and motivation levels. However, the time course of mood and motivation was not affected by the BL exposure, a nocturnal circadian trough occurring at 0630 in both light conditions.


Journal of Clinical and Experimental Neuropsychology | 2008

Spatial and temporal memories are affected by sleep fragmentation in obstructive sleep apnea syndrome

Agnès Daurat; Jean Foret; Jean-Luc Bret-Dibat; Carole Fureix; Michel Tiberge

This study evaluated episodic memory, with an emphasis on the recollection of spatial and temporal contexts, in 28 patients suffering from obstructive sleep apnea syndrome and 29 healthy controls. Recollection was assessed by means of the R/K paradigm and the process-dissociation procedure. Attentional abilities were also evaluated. A polysomnographic assessment, including nocturnal oxygen saturation and daytime sleepiness, was conducted. Recollection was strongly disturbed in patients, the number of microarousals being the best predictor of the memory deficit. Attention was only slightly disturbed. Results suggest a link between episodic memory deficit and those areas of the brain that are particularly sensitive to sleep fragmentation, in particular the hippocampus.


Neurosignals | 2000

Bright Light during Nighttime: Effects on the Circadian Regulation of Alertness and Performance

Agnès Daurat; J. Foret; O. Benoit; G. Mauco

The present studies evaluated to what extent duration (all-night or 4-hour exposures) and timing of nocturnal bright light (BL) (beginning or end of the night) modulate effects on vigilance. The results showed that all-night BL exposure is able to alleviate the nocturnal decrements in alertness and performance. However, under certain circumstances, this continuous BL exposure may induce adverse effects on mood and finally reveal to be counterproductive. Shorter BL exposure (4 h) during nighttime helps improve mood and performance, although the effects of short BL pulses were less efficacious than all-night BL exposure. The latter part of the night appears the best time for using the alerting effect of BL. The immediate alerting effect of BL seems to be mediated by a global activation of the central nervous system.


Psychopharmacology | 2000

Effects of zopiclone on the rest/activity rhythm after a westward flight across five time zones

Agnès Daurat; O. Benoit; A. Buguet

Abstract The effects of zopiclone on the rest/activity rhythm were investigated after a westward flight with a 5-h phase delay (Grenoble-Martinique). The rest/activity rhythm was recorded continuously with an actigraph monitor during a 6-day baseline episode in Grenoble and a 6-day sojourn in Martinique. Rectal temperature was recorded before the flight on day 2 and after the flight on days 2 and 5. Subjective jet-lag score was assessed before the flight on days 1 and 2 and in Martinique on days 1, 2, 5 and 6. Zopiclone (7.5 mg) or placebo were administered double blind 30 min prior to bedtime during the first 4 post-flight days (D1–D4). Under zopiclone treatment, sleep was less fragmented on the first post-flight night and the curtailment of sleep duration observed on D2 and D3 under placebo was prevented. During daytime, subjects tended to be more active than with placebo. By contrast, subjective jet-lag scores did not differ between both groups. Zopiclone seemed to accelerate the readjustment of the rest/activity rhythm and the normalisation of the phase relationship between sleep and the temperature rhythm. Zopiclone probably exerts its ”resetting” effects on jet-lag desynchronosis by facilitating sleep induction rather than via a chronobiotic action.


Neuroreport | 1993

Temperature drop and sleep: testing the contribution of SWS in keeping cool.

Helena Almirall; Acacia Aguirre; Rubén V. Rial; Agnès Daurat; Jean Foret; Odile Benoit

Sleep and body temperature characteristics were studied in man in baseline (B), 24 h-constant routine (CR) and recovery (R) after the CR. The sleep advanced and deepened the trough of the minimum temperature when compared with CR. No relevant difference in minimum body temperature, or in the slope of temperature decrease was found, however, between B and R sleeping nights. No correlation was found between the amount of slow wave sleep and body cooling. The results do not support a homeostatic role of slow wave sleep in brain and/or body cooling.


Accident Analysis & Prevention | 2013

Lorazepam impairs highway driving performance more than heavy alcohol consumption

Agnès Daurat; Patricia Sagaspe; Ladislav Moták; Jacques Taillard; Laëtitia Bayssac; Nathalie Huet; Colas Authié; Daniel Mestre; Pierre Philip

While research indicates that benzodiazepine (BZD)-like drugs impair driving performance, it remains unclear (i) how far BZDs affect lane-keeping performance, compared with alcohol and (ii) to what extent this impact can realistically be measured in a simulated environment. To clarify these issues, 16 healthy male drivers who had never previously taken BZDs underwent a randomized, crossover, double-blind, placebo-controlled driving paradigm (with the BZD lorazepam) in both real-world and simulated settings. Two lane-keeping variables, namely inappropriate line crossings (ILCs) and standard deviation of lateral position (SDLP), were recorded during the driving sessions. Analyses revealed that (i) a single lorazepam dose (2 mg given by mouth) caused higher SDLP increases than a blood alcohol concentration of above 0.05%, and that (ii) this BZD effect was amplified in the simulated driving setting, mainly for ILCs. As a consequence, we recommend that physicians be made more aware of BZD-related risks and that researchers make a clear distinction between the effects of BZD intake per se and the impact of simulated driving settings.


Journal of Neuropsychology | 2013

Decision making is affected in obstructive sleep apnoea syndrome.

Agnès Daurat; Matthieu Ricarrère; Michel Tiberge

We assessed decision making in 20 patients newly diagnosed with obstructive sleep apnoea (OSA) and 20 healthy controls with the Iowa Gambling Task (IGT), which evaluates the ability to learn to sacrifice immediate rewards in favour of long-term gains. A standard neuropsychological battery was administered. Switching scores tended to be lower in patients. Patients persisted in selecting risky decks throughout the IGT, whereas controls behaved normally. Performance was correlated with hypoxaemia. Brain regions underlying decision making may be affected by OSA-related hypoxaemia.


Memory | 2014

Memory monitoring and memory control in patients suffering from obstructive sleep apnoea syndrome

Agnès Daurat; Nathalie Huet; Michel Tiberge

Patients with obstructive sleep apnoea syndrome exhibit memory deficit. The present study looked at whether this deficit is related to impaired memory monitoring and/or memory control. Here 25 patients and 26 healthy controls performed a paired-associate learning task. After participants had made a judgement of learning for each pair and performed an initial recall test they were free to restudy any items they wished, for as long or little as they wished, within a 5-minute period. They then performed a second recall test. Monitoring and control processes were assessed on the basis of judgements of learning, item selection, and study-time allocation. In spite of their memory impairment, patients accurately predicted their recall. For the restudy phase patients preferentially selected the judged-easy items, while controls selected the judged-difficult items. However, all the participants allocated more restudy time to the judged-difficult items than to the judged-easy ones. There were no significant correlations between memory performance, metamemory processes, and clinical measures (i.e., subjective sleepiness, subjective sleep quality, anxiety, and depression scores). Results suggested that both memory monitoring and memory control were preserved in our sample of patients with obstructive sleep apnoea.


Journal of cognitive psychology | 2014

False memories in patients suffering from obstructive sleep apnoea syndrome (OSAS)

Majdouline Sarhane; Isabelle Etcheverry; Michel Tiberge; Agnès Daurat

We assessed the propensity for false memories among patients with obstructive sleep apnoea syndrome (OSAS). Twenty-one patients with OSAS and 21 controls matched for sex, age and education were recruited. At encoding, an adaptation of the Deese-Roediger-McDermott paradigm was used to induce false memories. At retrieval, participants completed a forced-choice recognition task to distinguish memories based on verbatim traces from those based on gist traces. When the task encouraged retrieval based on either gist or verbatim traces, the groups performed similarly. However, when the task required retrieval based solely on verbatim traces, OSAS patients exhibited poor discrimination and produced more false memories. Our finding that OSAS leads to an increased propensity to produce false memories is discussed within the framework of both fuzzy-trace theory and activation-monitoring theory.


Journal of Neuropsychology | 2017

Obstructive sleep apnoea syndrome increases source-confusion errors: A pilot study.

Majdouline Sarhane; Agnès Daurat

We explored external source monitoring (i.e., discrimination between memories of two externally derived sources) in patients with obstructive sleep apnoea syndrome (OSAS). Our specific aim was to ascertain whether, relative to controls, patients exhibit more source-confusion errors when there are similarities between two external memory sources. We recruited 22 patients with OSAS and 22 controls matched for sex, age, and education. The experimental procedure we used came in three phases. First, participants viewed a target film. Second, they were shown a mixed set of photographs, some taken from the film (target photographs), others not (photographs taken from other films not viewed by participants; lures). Lures differed either conceptually or perceptually from the target film. Third, the following day, participants were shown a set of photographs and urged to determine whether the photographs were taken from the target film or whether they were images they had seen for the first time in Phase 2. Patients correctly attributed the same number of target photographs to the target film as controls. By contrast, they incorrectly attributed more lures to the target film than controls did, especially when the lures were semantically similar to the film (perceptual lures). Both perceptual and conceptual source-confusion errors were significantly correlated with oxygen desaturation during sleep. Results suggest that the higher number of source-confusion errors observed in patients with OSAS was linked to an impaired ability to recollect specific perceptual details of the study items and that hypoxia is the main contributing factor to this deficit.

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Daniel Mestre

Aix-Marseille University

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