Agnieszka Czarny

The Friedländer synthesis of 4-perfluoroalkylquinolines

Abstract 2-Substituted and 2,3-disubstituted 4-perfluoroalkylquinolines are obtained in high yield by the acid-catalyzed reaction of 2-perfluoroacylanilines with enolizable ketones and β-diketones.

Synthesis of aminophenyl and methoxyphenyl perfluoroalkyl ketones

Abstract The title compounds are obtained by direct hydrolysis of the corresponding 2/4-perfluoroalkyl-substituted anilines and anisoles by the system AcOH/HBr/H 2 O/Al 2 O 3 . A two-step preparation of 2/4-perfluoroacylanilines involves the treatment of the 2/4-perfluoroalkylaniline with sodium ethoxide followed by hydrolysis of the resultant diethyl acetal with hydriodic acid.

Addition and lithiation reactions of N-(1-phenylalkylidene)anilines with lithium dialkylamides

Abstract Lithium diisopropylamide undergoes an addition reaction to the methyleneamino moiety of the title Schiffs bases substituted with a cyano group at the ortho or para position of the aniline, but mediates tautomerization of the unsubstituted and meta -substituted derivatives into secondary enamines. Only the tautomerization is observed for lithium 2,2,6,6-tetramethylpiperidide-mediated reactions.