Agnieszka Ścibior
John Paul II Catholic University of Lublin
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Featured researches published by Agnieszka Ścibior.
Journal of Toxicology and Environmental Health | 2007
Agnieszka Ścibior; Halina Zaporowska
This study investigated the selected parameters of the antioxidant system in liver and kidney after in vivo administration of vanadium and/or chromium in rats. Outbred 2-mo-old albino male Wistar rats received drinking water for 12 wk with either sodium metavanadate (SMV; group II); chromium chloride (Cr; group III); or sodium metavanadate and chromium chloride (SMV-Cr; group IV); and group I (control) received deionized water. Chronic treatment with V alone or in combination with Cr produced a significant increase in kidney relative weight. Further, giving rats V alone also led to a significant elevation in liver relative weight. An increase in hepatic Fe concentration and renal Zn content occurred after treatment with V or Cr, respectively. The rats coadministered V and Cr had significantly higher levels of Fe in liver and Zn in kidneys. Simultaneous administration of these two elements resulted in a significant decrease in renal L-ascorbic acid concentration. V given alone significantly decreased GSH content and GSH/GSSG ratio in liver and kidney as well as increased GSSG concentration in liver, whereas Cr alone produced a significant decrease in GSH content in kidney and GSH/GSSG ratio in both organs. In the SMV-Cr-treated group a significant decrease in renal GSH concentration and GSH/GSSG ratio in both organs occurred. A significant increase in liver GSSG content was also found. The observed significant changes in kidney GSH content and in GSH/GSSG ratio in both rat tissues after Cr might result from the pro-oxidant actions of this metal. Thus, oxidative stress, which is a major pathway for V-induced toxicity, might also be associated with Cr(III)-induced adverse effects in rats.
Oxidative Medicine and Cellular Longevity | 2013
Agnieszka Ścibior; Dorota Gołębiowska; Irmina Niedźwiecka
The protective effect of magnesium as magnesium sulfate (MS) on sodium-metavanadate- (SMV-) induced lipid peroxidation (LPO) under in vivo and in vitro conditions was studied. The 18-week SMV intoxication (Group II, 0.125 Vend/mL) enhanced spontaneous malondialdehyde (MDA) generation in rat liver, compared with the control (Group I) and MS-supplemented animals (Group III, 0.06 Mgend/mL). Coadministration of SMV with MS (Group IV, SMV-MS) caused a return of the MDA level to the control value range. The effect seems to result from the Mgend-independent action and its antagonistic interaction with Vend. The in vitro treatment of liver supernatants (LS) obtained from all the tested animals groups with selected exogenous concentrations of Feexg or Vexg exhibited enhanced MDA production, compared with spontaneously formed MDA. It also showed Mgexg-stimulating effect on LPO (LS I, Group I) and revealed that the changes in the MDA generation in LS IV (Group IV) might have resulted from the synergistic interactions of Vend with Feexg and Vexg and from the antagonistic interactions of Mgend with Feexg and Vexg. The findings allow a suggestion that adequate Mg intake for a specific period in the conditions of SMV exposure may prevent V-induced LPO in the liver.
BioMed Research International | 2014
Agnieszka Ścibior; Dorota Gołębiowska; Agnieszka Adamczyk; Irmina Niedźwiecka; Emilia Fornal
The alterations in the levels/activities of selected biomarkers for detecting kidney toxicity and in the levels of some oxidative stress (OS) markers and elements were studied in male rats to evaluate biochemically the degree of kidney damage, investigate the role of OS in the mechanism of functional renal disorders, reveal potential biomarkers of renal function, and assess the renal mineral changes in the conditions of a 12-week sodium metavanadate (SMV, 0.125 mg V/mL) exposure. The results showed that OS is involved in the mechanism underlying the development of SMV-induced functional renal disturbances. They also suggest that the urinary cystatin C (CysCu) and kidney injury molecule-1 (KIM-1u) could be the most appropriate to evaluate renal function at the conditions of SMV intoxication when the fluid intake, excreted urinary volume (EUV), body weight (BW), and the urinary creatinine excretion (Creu) decreased. The use of such tests as the urinary lactate dehydrogenase, alkaline phosphatase, γ-glutamyltranspeptidase, and N-acetyl-β-D-glucosaminidase (LDHu, ALPu, GGTPu, and NAGu) seems not to be valid given their reduced activities. The use of only traditional biomarkers of renal function in these conditions may, in turn, be insufficient because their alterations are greatly influenced by the changes in the fluid intake and/or BW.
Archives of Environmental Contamination and Toxicology | 2006
Agnieszka Ścibior; Halina Zaporowska; Jarosław Ostrowski
Environmental Toxicology and Pharmacology | 2010
Agnieszka Ścibior; Halina Zaporowska
Cell Biology and Toxicology | 2010
Agnieszka Ścibior; Halina Zaporowska; Agnieszka Wolińska; Jarosław Ostrowski
Environmental Toxicology and Pharmacology | 2012
Agnieszka Ścibior; Agnieszka Adamczyk; Dorota Gołębiowska; Irmina Niedźwiecka
Metallomics | 2014
Agnieszka Ścibior; Agnieszka Adamczyk; Dorota Gołębiowska; Irmina Niedźwiecka; Emilia Fornal
Chemico-Biological Interactions | 2016
Agnieszka Ścibior
Chemico-Biological Interactions | 2018
Agnieszka Ścibior; Dorota Gołębiowska; Agnieszka Adamczyk; Joanna Kurus; Magdalena Staniszewska; Ilona Sadok