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Dive into the research topics where Agnieszka Ścibior is active.

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Featured researches published by Agnieszka Ścibior.


Journal of Toxicology and Environmental Health | 2007

Effects of Vanadium(V) and/or Chromium(III) on L-Ascorbic Acid and Glutathione as well as Iron, Zinc, and Copper Levels in Rat Liver and Kidney

Agnieszka Ścibior; Halina Zaporowska

This study investigated the selected parameters of the antioxidant system in liver and kidney after in vivo administration of vanadium and/or chromium in rats. Outbred 2-mo-old albino male Wistar rats received drinking water for 12 wk with either sodium metavanadate (SMV; group II); chromium chloride (Cr; group III); or sodium metavanadate and chromium chloride (SMV-Cr; group IV); and group I (control) received deionized water. Chronic treatment with V alone or in combination with Cr produced a significant increase in kidney relative weight. Further, giving rats V alone also led to a significant elevation in liver relative weight. An increase in hepatic Fe concentration and renal Zn content occurred after treatment with V or Cr, respectively. The rats coadministered V and Cr had significantly higher levels of Fe in liver and Zn in kidneys. Simultaneous administration of these two elements resulted in a significant decrease in renal L-ascorbic acid concentration. V given alone significantly decreased GSH content and GSH/GSSG ratio in liver and kidney as well as increased GSSG concentration in liver, whereas Cr alone produced a significant decrease in GSH content in kidney and GSH/GSSG ratio in both organs. In the SMV-Cr-treated group a significant decrease in renal GSH concentration and GSH/GSSG ratio in both organs occurred. A significant increase in liver GSSG content was also found. The observed significant changes in kidney GSH content and in GSH/GSSG ratio in both rat tissues after Cr might result from the pro-oxidant actions of this metal. Thus, oxidative stress, which is a major pathway for V-induced toxicity, might also be associated with Cr(III)-induced adverse effects in rats.


Oxidative Medicine and Cellular Longevity | 2013

Magnesium Can Protect against Vanadium-Induced Lipid Peroxidation in the Hepatic Tissue

Agnieszka Ścibior; Dorota Gołębiowska; Irmina Niedźwiecka

The protective effect of magnesium as magnesium sulfate (MS) on sodium-metavanadate- (SMV-) induced lipid peroxidation (LPO) under in vivo and in vitro conditions was studied. The 18-week SMV intoxication (Group II, 0.125 Vend/mL) enhanced spontaneous malondialdehyde (MDA) generation in rat liver, compared with the control (Group I) and MS-supplemented animals (Group III, 0.06 Mgend/mL). Coadministration of SMV with MS (Group IV, SMV-MS) caused a return of the MDA level to the control value range. The effect seems to result from the Mgend-independent action and its antagonistic interaction with Vend. The in vitro treatment of liver supernatants (LS) obtained from all the tested animals groups with selected exogenous concentrations of Feexg or Vexg exhibited enhanced MDA production, compared with spontaneously formed MDA. It also showed Mgexg-stimulating effect on LPO (LS I, Group I) and revealed that the changes in the MDA generation in LS IV (Group IV) might have resulted from the synergistic interactions of Vend with Feexg and Vexg and from the antagonistic interactions of Mgend with Feexg and Vexg. The findings allow a suggestion that adequate Mg intake for a specific period in the conditions of SMV exposure may prevent V-induced LPO in the liver.


BioMed Research International | 2014

The Renal Effects of Vanadate Exposure: Potential Biomarkers and Oxidative Stress as a Mechanism of Functional Renal Disorders—Preliminary Studies

Agnieszka Ścibior; Dorota Gołębiowska; Agnieszka Adamczyk; Irmina Niedźwiecka; Emilia Fornal

The alterations in the levels/activities of selected biomarkers for detecting kidney toxicity and in the levels of some oxidative stress (OS) markers and elements were studied in male rats to evaluate biochemically the degree of kidney damage, investigate the role of OS in the mechanism of functional renal disorders, reveal potential biomarkers of renal function, and assess the renal mineral changes in the conditions of a 12-week sodium metavanadate (SMV, 0.125 mg V/mL) exposure. The results showed that OS is involved in the mechanism underlying the development of SMV-induced functional renal disturbances. They also suggest that the urinary cystatin C (CysCu) and kidney injury molecule-1 (KIM-1u) could be the most appropriate to evaluate renal function at the conditions of SMV intoxication when the fluid intake, excreted urinary volume (EUV), body weight (BW), and the urinary creatinine excretion (Creu) decreased. The use of such tests as the urinary lactate dehydrogenase, alkaline phosphatase, γ-glutamyltranspeptidase, and N-acetyl-β-D-glucosaminidase (LDHu, ALPu, GGTPu, and NAGu) seems not to be valid given their reduced activities. The use of only traditional biomarkers of renal function in these conditions may, in turn, be insufficient because their alterations are greatly influenced by the changes in the fluid intake and/or BW.


Archives of Environmental Contamination and Toxicology | 2006

Selected Haematological and Biochemical Parameters of Blood in Rats After Subchronic Administration of Vanadium and/or Magnesium in Drinking Water

Agnieszka Ścibior; Halina Zaporowska; Jarosław Ostrowski


Environmental Toxicology and Pharmacology | 2010

Effects of combined vanadate and magnesium treatment on erythrocyte antioxidant defence system in rats

Agnieszka Ścibior; Halina Zaporowska


Cell Biology and Toxicology | 2010

Antioxidant enzyme activity and lipid peroxidation in the blood of rats co-treated with vanadium (V+5) and chromium (Cr+3)

Agnieszka Ścibior; Halina Zaporowska; Agnieszka Wolińska; Jarosław Ostrowski


Environmental Toxicology and Pharmacology | 2012

Effect of 12-week vanadate and magnesium co-administration on chosen haematological parameters as well as on some indices of iron and copper metabolism and biomarkers of oxidative stress in rats

Agnieszka Ścibior; Agnieszka Adamczyk; Dorota Gołębiowska; Irmina Niedźwiecka


Metallomics | 2014

The influence of combined magnesium and vanadate administration on the level of some elements in selected rat organs: V–Mg interactions and the role of iron-essential protein (DMT-1) in the mechanism underlying altered tissues iron level

Agnieszka Ścibior; Agnieszka Adamczyk; Dorota Gołębiowska; Irmina Niedźwiecka; Emilia Fornal


Chemico-Biological Interactions | 2016

Vanadium (V) and magnesium (Mg) - In vivo interactions: A review.

Agnieszka Ścibior


Chemico-Biological Interactions | 2018

Evaluation of lipid peroxidation and antioxidant defense mechanisms in the bone of rats in conditions of separate and combined administration of vanadium (V) and magnesium (Mg)

Agnieszka Ścibior; Dorota Gołębiowska; Agnieszka Adamczyk; Joanna Kurus; Magdalena Staniszewska; Ilona Sadok

Collaboration


Dive into the Agnieszka Ścibior's collaboration.

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Dorota Gołębiowska

John Paul II Catholic University of Lublin

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Agnieszka Adamczyk

John Paul II Catholic University of Lublin

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Irmina Niedźwiecka

John Paul II Catholic University of Lublin

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Halina Zaporowska

John Paul II Catholic University of Lublin

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Emilia Fornal

John Paul II Catholic University of Lublin

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Joanna Kurus

John Paul II Catholic University of Lublin

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Daniel Klich

Warsaw University of Life Sciences

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Ilona Sadok

John Paul II Catholic University of Lublin

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Kajetan Perzanowski

John Paul II Catholic University of Lublin

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Magdalena Staniszewska

John Paul II Catholic University of Lublin

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