Ahmad Abdi

بررسی تمرینات ترکیبی کوتاه مدت بر بیان ژنهای سرکوبگر تومور P53 و P21 در مردان مبتلابه سرطان پروستات

Introduction: Prostate cancer is one of the most important causes of cancer deaths in men. The presence of tumor suppressor proteins is one of the regulatory mechanisms for controlling the progression of the disease. The purpose of this study was to investigate the review of short-term concurrent training on expression of P53 and P21 tumor suppressor genes in men with adenocarcinoma type of prostate cancer. Methods: In this semi-experimental study, by referring to the pathology department of the Baqiyatallah El - Azam Subspeciality Hospital in Tehran and reviewing the medical records of men with prostate cancer in the first six months of 2016, twenty men with adenocarcinoma type of prostate cancer at the T1 and T2 stage with an average age 62.60±7.71 years and body mass index 26.10 ± 3.40 kg / m2 were randomly selected and divided into control (n=10) and experimental (n=10) groups. The experimental group performed Concurrent Training for three days a week within eight weeks, including resistance training with 60-75% of a maximal repeat and aerobic exercise with 60-75% of maximum heart rate. The expression of P53 and P21 genes was measured by Real-Time PCR and analyzed by independent/paired T test. Results: The results showed that short-term concurrent training increased significantly P53 gene expression (P=0.000) and P21 gene expression (P=0.00) in the experimental group, and compared with the control group (P=0.00). There was no significant difference between P21 and P53 gene expression in the control group (P>0.05). Conclusion: Significant increase in aerobic power and muscle strength following short-term concurrent training and its consequent significant increase in tumor suppressor proteins may possibly reduce the progression of adenocarcinoma type of prostate cancer tumors.

مطالعه تاثير عصاره عناب طي يك دوره تمرين استقامتي بر بافت قلب رت های نر ویستار مسموم شده با بولدنون

Introduction: The aim of this study was to evaluate the effect of Ziziphus Jujube extract during endurance training on cardiac tissue in Wistar male rats toxicated by Boldenone. Methods: Thirty male Wistar rats aged 8-12 weeks (weight 195±7.94g) were randomly assigned to five groups: control, Boldenone (5 mg/kg), Ziziphus Jujube extract, endurance training- Ziziphus Jujube extract and Non-treated group. The endurance training program with moderate intensity (50-55% maximal oxygen consumption) was performed five times a week for six weeks. Injection was done once a week, on an appointed day, and in depth of the hamstring. After anesthesia, autopsy was performed and the cardiac tissue was isolated. Results: The results showed that the Boldenone caused damage to the heart tissue muscle and heart muscle cells. Also, Boldenone was the reason of mild necrosis and congestion in heart tissue. The rate of change of heart tissue and inflammation were high in extract group. However, the results showed that Ziziphus Jujube extract with endurance training could decrease to normal levels damage to the heart tissue muscle and heart muscle cells. Conclusion: According to the findings, it seems that Boldenone caused structural damage of heart tissue, and possibly endurance training with Ziziphus Jujube extract could reduce the damages.