Ahmad Fahmi Harun Ismail
International Islamic University Malaysia
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Featured researches published by Ahmad Fahmi Harun Ismail.
journal of applied pharmaceutical science | 2016
Ahmad Fahmi Harun Ismail; Farahidah Mohamed; Luqman Muizzuddin Mohd Rosli; Mohd Affendi Mohd Shafri; Muhammad Salahuddin Haris; Anugerah Budipratama Adina
The purpose of this study was to provide a quantification method with rapid, sensitive, reproducible and cost effective for gentamicin in the form of ninhydrin-gentamicin complex. The utilization of spectrophotometric module to validate the method development for gentamicin loaded microparticles was intended to provide alternative quantification method without compromising the sensitivity of the developed method. The wavelength was determined to be at 418 nm with 421 nm and 415 nm were selected for the robustness of the method selectivity. The linearity of 6 known concentrations of ninhydrin-gentamicin complex was obtained with the R2 of 0.9998. The interday and intraday precisions were determined with the acceptance %RSD values of less than 2%. In fact, the highest %RSD value was 1.09% which suggested the method to be acceptably precise. The LOD and LOQ values were recorded to be at 0.016 mg/mL and 0.196 mg/mL respectively. The % recovery of 4 known concentrations indicated the accuracy of the method was high with the recovery range between 98.66% to 101.8%. The parameters analyzed in this study were in accordance with ICH Q2 (R1) guidelines. This quantification method developed by using spectrophotometric module was a promising approach to provide a rapid and cost effective in evaluating gentamicin concentration for in-vitro applications.
journal of applied pharmaceutical science | 2015
Ahmad Fahmi Harun Ismail; Abd Almonem Doolaanea; Farahidah Mohamed; Nur 'Izzati Mansor; Mohd Affendi Mohd Shafri; Fathin Athirah Yusof
Nigella sativa oil (NSO) has been exploited for medical purposes for many generations. The fabrication of microparticles containing NSO intended for sustained release was done to be used in treating osteomyelitis. Method in quantifying NSO using UV-spectroscopy was developed and validated. Linearity shown a good correlation coefficient with the values higher than 0.995, both for actual and different analysts. The LOD and LOQ values were recorded to be 2.89 µg/mL and 8.75 µg/mL respectively. In addition, the highest %RSD values for the intermediate and repeatability studies were 0.970% and 0.445% which suggested the method was precise. The percentage recovery for 4 known concentrations gave the range between 98.16% to 99.39%, indicating the high accuracy of the method. The parameters analyzed in this study were in accordance with ICH Q2 (R1) guidelines.
Archive | 2012
Ahmad Fahmi Harun Ismail; Abd Monem Doolaanea; Mohamed Awang; Farahidah Mohamed
Tropical Journal of Pharmaceutical Research | 2015
Abd Almonem Doolaanea; Ahmad Fahmi Harun Ismail; Nur 'Izzati Mansor; Nurul Hafizah Mohd Nor; Farahidah Mohamed
Archive | 2015
Farahidah Mohamed; Mohd Affendi Mohd Shafri; Nazri Mohd Yusof; Ahmad Fahmi Harun Ismail; Khairul Ikhwan Yaacob; Fatin Athirah Yusof; Intan Azura Shahdan
Archive | 2014
Ahmad Fahmi Harun Ismail; Farahidah Mohamed; Nazri Mohd Yusof; Mohd Affendi Mohd Shafri
Archive | 2012
Najihah Mohamad Shukri; Nur Afera Abd Ghani; Wan mariana Wan Osman; Ahmad Fahmi Harun Ismail; Farahidah Mohamed
Archive | 2012
Ahmad Fahmi Harun Ismail; Mohamed Awang
Archive | 2011
Farahidah Mohamed; Ahmad Fahmi Harun Ismail; Abd Monem Doolaane
Archive | 2011
Farahidah Mohamed; Ahmad Fahmi Harun Ismail; Abd Monem Doolane