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Dive into the research topics where Ahmad Fahmi Harun Ismail is active.

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Featured researches published by Ahmad Fahmi Harun Ismail.


journal of applied pharmaceutical science | 2016

Spectrophotometric Determination of Gentamicin Loaded PLGA Microparticles and Method Validation via Ninhydrin-Gentamicin Complex as a Rapid Quantification Approach

Ahmad Fahmi Harun Ismail; Farahidah Mohamed; Luqman Muizzuddin Mohd Rosli; Mohd Affendi Mohd Shafri; Muhammad Salahuddin Haris; Anugerah Budipratama Adina

The purpose of this study was to provide a quantification method with rapid, sensitive, reproducible and cost effective for gentamicin in the form of ninhydrin-gentamicin complex. The utilization of spectrophotometric module to validate the method development for gentamicin loaded microparticles was intended to provide alternative quantification method without compromising the sensitivity of the developed method. The wavelength was determined to be at 418 nm with 421 nm and 415 nm were selected for the robustness of the method selectivity. The linearity of 6 known concentrations of ninhydrin-gentamicin complex was obtained with the R2 of 0.9998. The interday and intraday precisions were determined with the acceptance %RSD values of less than 2%. In fact, the highest %RSD value was 1.09% which suggested the method to be acceptably precise. The LOD and LOQ values were recorded to be at 0.016 mg/mL and 0.196 mg/mL respectively. The % recovery of 4 known concentrations indicated the accuracy of the method was high with the recovery range between 98.66% to 101.8%. The parameters analyzed in this study were in accordance with ICH Q2 (R1) guidelines. This quantification method developed by using spectrophotometric module was a promising approach to provide a rapid and cost effective in evaluating gentamicin concentration for in-vitro applications.


journal of applied pharmaceutical science | 2015

Method Development and Validation using UV Spectrophotometry for Nigella sativa Oil Microparticles Quantification

Ahmad Fahmi Harun Ismail; Abd Almonem Doolaanea; Farahidah Mohamed; Nur 'Izzati Mansor; Mohd Affendi Mohd Shafri; Fathin Athirah Yusof

Nigella sativa oil (NSO) has been exploited for medical purposes for many generations. The fabrication of microparticles containing NSO intended for sustained release was done to be used in treating osteomyelitis. Method in quantifying NSO using UV-spectroscopy was developed and validated. Linearity shown a good correlation coefficient with the values higher than 0.995, both for actual and different analysts. The LOD and LOQ values were recorded to be 2.89 µg/mL and 8.75 µg/mL respectively. In addition, the highest %RSD values for the intermediate and repeatability studies were 0.970% and 0.445% which suggested the method was precise. The percentage recovery for 4 known concentrations gave the range between 98.16% to 99.39%, indicating the high accuracy of the method. The parameters analyzed in this study were in accordance with ICH Q2 (R1) guidelines.


Archive | 2012

High initial burst release of gentamicin formulated as PLGA microspheres implant for treating orthopaedic infection

Ahmad Fahmi Harun Ismail; Abd Monem Doolaanea; Mohamed Awang; Farahidah Mohamed


Tropical Journal of Pharmaceutical Research | 2015

Effect of Surfactants on Plasmid DNA Stability and Release from Poly (D,L-lactide-co-glycolide) Microspheres

Abd Almonem Doolaanea; Ahmad Fahmi Harun Ismail; Nur 'Izzati Mansor; Nurul Hafizah Mohd Nor; Farahidah Mohamed


Archive | 2015

Antibiotic-Nigella Sativa Fusion (ANF) as a novel approach intended for the treatment against bacteria forming biofilm in osteomyelitis

Farahidah Mohamed; Mohd Affendi Mohd Shafri; Nazri Mohd Yusof; Ahmad Fahmi Harun Ismail; Khairul Ikhwan Yaacob; Fatin Athirah Yusof; Intan Azura Shahdan


Archive | 2014

Compatibility characterization of Gentamicin-Nigella sativa fusion as a future greener pharmaceutical intended for ortheopaedic infection

Ahmad Fahmi Harun Ismail; Farahidah Mohamed; Nazri Mohd Yusof; Mohd Affendi Mohd Shafri


Archive | 2012

Effect of N. Sativa on Characteristics of gentamicin-loaded chitosan/PLGA microspheres

Najihah Mohamad Shukri; Nur Afera Abd Ghani; Wan mariana Wan Osman; Ahmad Fahmi Harun Ismail; Farahidah Mohamed


Archive | 2012

HIGH INITIAL BURST RELEASE OF GENTAMICIN FORMULATED AS PLGA MICROSPHERES IMPLANT FOR TREATING ORTHOPAEDIC INFECTION Research Article

Ahmad Fahmi Harun Ismail; Mohamed Awang


Archive | 2011

Microencapsulation of gentamicin into biodegradable polymer as a novel drug delivery system

Farahidah Mohamed; Ahmad Fahmi Harun Ismail; Abd Monem Doolaane


Archive | 2011

Microencapsulation of drug into biodegradable polymer as a novel drug delivery system

Farahidah Mohamed; Ahmad Fahmi Harun Ismail; Abd Monem Doolane

Collaboration


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Farahidah Mohamed

International Islamic University Malaysia

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Mohd Affendi Mohd Shafri

International Islamic University Malaysia

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Abd Almonem Doolaanea

International Islamic University Malaysia

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Mohamed Awang

International Islamic University Malaysia

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Nazri Mohd Yusof

International Islamic University Malaysia

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Nur 'Izzati Mansor

International Islamic University Malaysia

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Aimen Abdo Elsaid Ali

International Islamic University Malaysia

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Fathin Athirah Yusof

International Islamic University Malaysia

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Intan Azura Shahdan

International Islamic University Malaysia

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Kausar Ahmad

International Islamic University Malaysia

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