Ahmed Bari

3-(1-Adamant­yl)-1-{[4-(2-meth­oxy­phen­yl)piperazin-1-yl]meth­yl}-4-methyl-1H-1,2,4-triazole-5(4H)-thione

The title compound, C25H35N5OS, is a functionalized triazoline-3-thione with substituted piperazine and adamantyl substituents attached at the 2- and 5-positions, respectively, of a triazole spacer with an approximately C-shaped conformation of the molecule. The piperazine ring adopts a chair conformation.

Microwave-Assisted One-Step Synthesis of Fenamic Acid Hydrazides from the Corresponding Acids

A facile and efficient method for synthesis of fenamic acid hydrazides from their acids in one-step reaction under microwave irradiation and solvent-free conditions was developed. Compared with the two-step conventional heating method, the process was simple, the reaction time was very short and the yields were almost quantitative.

Synthesis of Some New Heterocyclic Compounds Derived from 3-Formylchromones and Their Antimicrobial Evaluation

The synthesis and antimicrobial evaluation of a series of chromone-linked substituted heterocyclic derivatives is described. The condensation of 3-formylchromone with acetoacetamide under Knoevenagel–Cope reaction conditions was also explored, and the condensation with 4-hydroxy-6-methyl-2H-pyran-2-one constitutes a facile route to pyranopyrone fused systems. Most of the compounds exhibit good antimicrobial properties.

N'-[(2-n-Butyl-4-chloro-1H-imidazol-5-yl)-methyl-idene]adamantane-1-carbo-hydrazide sesquihydrate ethanol hemi-solvate.

In the asymmetric unit of the title compound, C19H27ClN4O·0.5C2H6O·1.5H2O, there are two molecules of the Schiff base, which has a rigid adamantyl cage at one end of the C(= O)NH–N=CH– chain and an almost planar [torsion angles = 1.3 (1) and 7.9 (2)° imidazolyl ring at the other end, three molecules of water and one molecule of ethanol. In both independent molecules of the Schiff base, this chain displays an extended zigzag configuration. All their amino groups function as hydrogen-bond donors to water molecules; these are linked to other acceptor atoms, generating a layer structure. O—H⋯O and O—H⋯N interactions involving the water molecules also occur.

3,4,7-Trimethyl-2-(4-methyl-phen-yl)-2H-pyrazolo-[3,4-d]pyridazin-5-ium thio-cyanate.

1,1′-[5-Methyl-1-(4-methylphenyl)-1H-pyrazole-3,4-diyl)diethanone condenses with thiosemicarbazide in the presence of acetic acid to form the title salt, C15H17N4 +·NCS−. The fused-ring system of the cation is almost planar (r.m.s. deviation = 0.020 Å) and the aromatic substituent is aligned at an angle of 48.2 (1)° with respect to the mean plane of the fused-ring system. The N atom at the 5-position is protonated and forms a N—H⋯N hydrogen bond to the thiocyanate cointer-ion.

Neoclerodane Diterpenoids from Reehal Fatima, Teucrium yemense

Teucrium yemense (Defl), locally known as Reehal Fatima, is a medicinal plant commonly grown in Saudi Arabia and Yemen. Phytochemical investigation of the aerial parts of T. yemense yielded six new neoclerodane diterpenoids, namely fatimanol A-E (1, 2, 3, 5, and 6) and fatimanone (4), and the known teulepicephin (7). As both the Teucrium genus and the related Lamiaceae family have previously been widely reported to possess anthelmintic and antimicrobial activities, the structural and biological characterization of the seven diterpenoids was pursued. The structures of the new compounds were elucidated from their 2D NMR and MS profiles and by comparison to related compounds. The structure of fatimanol D (5) was confirmed by X-ray crystallographic analysis. The new structures contribute to the breadth of knowledge of secondary metabolites in this genus.

2-Eth-oxy-5-methylbis[1,2,4]triazolo[1,5-a:4',3'-c]quinazoline.

The title compound, C13H12N6O, is a functionalized ditriazoloquinazoline with substituted ethoxy and methyl groups attached at the 2-position of each triazole spacer. The fused-ring system is essentially planar [r.m.s. deviation = 0.016 (2) Å]. In the crystal, a weak C—H⋯N hydrogen bond connects the molecules into a chain along [101].

rac-2-Amino-1,2-diphenyl-ethanol.

In the title compound, C14H15NO, the torsion angle about the two Csp 3 atoms adopts a partially eclipsed conformation [−61.5 (1)°]. The dihedral angle between the two rings is 48.1 (1)°. In the crystal, the molecules are connected by O—H⋯N and N—H⋯O hydrogen bonds into zigzag chains running along [010]. One of the amino H atoms is not involved in hydrogen bonding.

3-[(E)-3-(4-Meth­oxy­phen­yl)prop-2-eno­yl]-1-(4-methyl­phen­yl)-5-phenyl-1H-pyrazole-4-carbonitrile

In the title compound, C27H21N3O2, the non-H atoms of the methoxyphenylacryloyl substitutent of the pyrazolyl ring are almost co-planar (r.m.s. deviation = 0.070 Å), and the mean plane is twisted by 18.7 (1)° with respect to the pyrazolyl ring. The phenyl and tolyl substituents are aligned at 48.9 (1) and 44.5 (1)° with respect to the pyrazolyl ring. Weak intermolecular C—H⋯O and C—H⋯N hydrogen bonding is present in the crystal structure.

Ethyl 5-bromo-1-benzofuran-2-carboxyl-ate.

In the title compound, C11H9BrO3, the benzofuran fused-ring system is almost planar, with a maximum atomic deviation of 0.024 (5) Å; the carboxyl –CO2 fragment is aligned at 4.8 (7)° with respect to the fused-ring plane. Weak intermolecular C—H⋯O hydrogen bonding is present in the crystal structure. π–π stacking is also observed between parallel molecules, the centroid–centroid distance between benzene and furan rings of adjacent molecules being 3.662 (3) Å.