Ahmed Jahid

Renal myelolipoma: a rare extra-adrenal tumor in a rare site: a case report and review of the literature

IntroductionMyelolipomas are uncommon, benign tumors composed of mature adipose tissue and hematopoietic elements. They mostly occur in the adrenal glands, but extra-adrenal myelolipomas have also been reported in other locations such as the presacral region, retroperitoneum, pelvis and mediastinum. Here, we present a case of an extra-adrenal myelolipoma in a rare site: the renal parenchyma. To the best of our knowledge, it is only the third case reported in this unusual location.Case presentationWe report a case of primary myelolipoma occurring in the kidney of a 55-year-old Moroccan man. We describe the radiological and clinicopathologic features of this unusual tumor with a review of the literature, and we discuss differential diagnosis of retroperitoneal myelolipomas.ConclusionThis case is noteworthy because the tumor site was unusual. Although renal myelolipoma is rare, it should be considered in the differential diagnosis of lesions in this site.

A gallbladder tumor revealing metastatic clear cell renal carcinoma: report of case and review of literature

Metastatic renal cell carcinoma in the gallbladder is extremely rare, with reported frequencies of less than 0.6% in large autopsy reviews. Only 40 cases were reported in the literature. We report a first case of gallbladder polypoid tumor revealing metastatic clear cell renal cell carcinoma, which demonstrates the importance of radiological tests, histology and immunohistochemistry when making a definitive diagnosis. These examinations also allow differentiating metastatic clear cell renal cell carcinoma from other polypoid lesions in the gallbladder with clear cell morphology. Cholecystectomy should be performed to obtain a definitive diagnosis and to improve survival in case of solitary metastatic renal cell carcinoma.Virtual slidesThe virtual slides’ for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/8956897238238989

Primary retroperitoneal mucinous cystadenoma with borderline malignancy in a male patient: a case report

IntroductionPrimary retroperitoneal mucinous cystadenoma is a rare tumor prevailing specifically in female gender. Its histogenesis is still unclear and its diagnosis is mainly based on morphological characteristics.Case presentationthe subject is a 44 years old man presenting an abdominal pain on the right side, with a palpable mass which appeared four months ago. Abdominal ultrasound (echography) revealed a retroperitoneal cystic process, which was successfully resected through laparotomy.Histopathological examination concluded to a mucinous cystadenoma with borderline malignancy foci.After a year of follow-up, no relapse was noticed in this patient.ConclusionRetroperitoneal mucinous cystadenoma is a rare tumor that should be considered in front of a retroperitoneal cystic process. Several hypotheses may explain the histogenesis of this pathological process.The interest in publishing this case report on primary retroperitoneal mucinous cystadenoma in a male patient lies in the rarity of occurrence of this syndrom in males as compared to females.

Combined myoepithelial carcinoma and myoepithelioma in soft tissue: a case report and review of the literature

IntroductionSoft tissue myoepithelial carcinoma and myoepithelioma are rare entities, part of myoepithelial tumors. They were incorporated into the World Health Organization classification of soft tissue tumors in 2002. Here we present an exceptional case of myoepithelial carcinoma and myoepithelioma association. To the best of our knowledge, such an association has never been reported in the literature.Case presentationWe report a case of myoepithelial carcinoma combined with myoepithelioma occurring in the soft tissue of the right forearm of an 84-year-old Arabian man. We describe the clinical, radiological and pathological features dominated by histological polymorphism. We will also describe the proposed histological criteria of malignancy and the major role of immunohistochemistry in positive and differential diagnosis. We finally mention the therapeutic arsenal available.ConclusionThrough this work, we report that myoepithelioma of soft tissue can progress to malignant myoepithelioma.

Juxtaglomerular cell tumor: a distinct mesenchymal tumor of kidney.

Juxtaglomerular cell tumor (JGCT) is an unusual mesenchymal entity of the kidney. It is a benign renin-secreting tumor causing hypertension and hypokalemia due to secondary hyperaldosteronism. It is curable if it is discovered early and surgically removed, but may cause a fatal outcome usually due to complications of associated hypertension.

Calcified multilocular thymic cyst associated with thymoma: a case report

IntroductionThere are few case reports of thymoma with a thymic cyst. Such an association renders it difficult for any pathologist to differentiate from other neoplasms, such as a cystic thymoma.Case presentationA 50-year-old Berber woman from Morocco was admitted with a chronic cough of more than 10 years duration. Her medical history and physical examination were normal. Anterior chest radiography demonstrated a calcified opacity in her right anterior mediastinum. A chest-computed tomogram revealed a round cystic tumor, with significant calcification in her right anterior mediastinum. A surgical exploration was performed. The tumor seemed to be a well-encapsulated and totally calcified lesion, arising from the right lobe of her thymus. It was removed by partial resection of her thymus. Through histology, the calcified tumor exhibited some areas of multilocular fibrous-wall cysts. These cysts were partially lined by small cuboidal cells with severe chronic inflammation and an AB thymoma that arose from the wall of the cyst.ConclusionGreater attention should be given to multilocular thymic cysts, to exclude the possibility of neoplasm, especially when the cyst wall is thickened.

Primary endobronchial leiomyosarcoma of the lung: clinical, gross and microscopic findings of two cases.

Primary leiomyosarcoma of the lung is an unusual malignant tumor. Among this entity, the endobronchial form is very rare and the preoperative diagnosis is extremely difficult. We present two different presentations and outcomes of primary endobronchial leiomyosarcoma of the lung. In both cases, the histological study and the immunohistochemical stain, of the surgical resection, provided the final diagnosis. Through those cases we present the diagnostic and therapeutic difficulties encountered.

Une localisation inhabituelle d’une pathologie rare : la tumeur costale à cellules géantes: À propos d’un cas avec revue de la littérature

Resume Introduction Les tumeurs osseuses a cellules geantes sont des tumeurs primitives rares affectant essentiellement l’adulte jeune et caracterisees par une legere predominance feminine. Observations Dans l’observation presentee, il s’agit d’une patiente âgee de 27 ans qui souffrait depuis une annee de l’apparition d’une voussure thoracique retro-mammaire droite douloureuse ayant progressivement augmente de volume. L’examen clinique trouvait une masse dure, fixee a la paroi thoracique, mesurant 8 x 6 cm et sans signes inflammatoires en regard. La radiographie thoracique montrait une opacite mal limitee se projetant sur l’arc anterieur de la quatrieme cote droite et que la tomodensitometrie thoracique rattachait a un processus tissulaire costal non invasif. Le bilan etiologique, fonctionnel et d’extension ne relevait pas d’anomalies. Un prelevement cytologique a l’aiguille fine faisait suspecter le diagnostic. Une resection chirurgicale en bloc de la tumeur montrait alors a l’analyse histo-pathologique l’aspect d’une tumeur osseuse a cellules geantes. Les suites operatoires etaient simples et le suivi sur 12 mois etait satisfaisant. Conclusion La particularite de notre observation est le caractere rare a la fois de la pathologie rapportee et de sa localisation costale. Les auteurs insistent egalement sur l’interet du diagnostic precoce et du traitement chirurgical radical ainsi que de la surveillance etroite en raison du risque de recidive locale voire de degenerescence maligne. Ils passent enfin en revue les donnees de la litterature recente concernant cette pathologie.

Carcinome sarcomatoïde biphasique de la thyroïde : localisation exceptionnelle d’une tumeur rare

Le carcinome sarcomatoide thyroidien est une tumeur rare reputee de mauvais pronostic. Elle se caracterise par l’intrication d’un carcinome vesiculaire et d’un sarcome. Nous rapportons le cas d’une tumeur thyroidienne gauche, composite, chez une femme de 62 ans qui infiltrait la totalite de la glande. Les resultats du marquage immunoperoxydasique furent positifs pour la thyroglobuline et les marqueurs epitheliaux dans le carcinome vesiculaire et negatifs dans le composant sarcomateux confirmant le diagnostic d’un carcinome sarcomatoide biphasique thyroidien. La patiente est decedee quelques jours plus tard par un choc septique. La definition et l’histogenese de ces tumeurs sont controversees dans la litterature. Actuellement, on pense qu’elles ont une origine monoclonale et qu’elles deriveraient d’une meme cellule souche multipotente. Seront discutes la definition des carcinomes sarcomatoides, leur morphologie, leur histogenese ainsi que leur pronostic.

Primary solitary fibrous tumor of the retroperitoneum

Solitary fibrous tumor is an uncommon neoplasm affecting adults and typically located in the pleura and can also occur in a large number of other extra thoracic sites. We present the case of a solitary fibrous tumor (SFT) of the retroperitoneum and describe their histopathological and immunohistochemical features. The identification of SFT in the retroperitoneum is of importance because its clinico-pathological behaviour is still unclear. The pathologist plays a fundamental role in establishing both the positive and differential diagnosis.