Ahmed S. Badr El-din

A novel hydrogen bonded bimetallic supramolecular coordination polymer {[SnMe3(bpe)][Ag(CN)2] · 2H2O} as anticancer drug.

The reaction of Me(3)SnCl, K(3)[Ag(CN)(4)] and 1,2-bis(4-pyridyl)ethane (bpe) in water/CH(3)CN solution at room temperature affords the novel bimetallic supramolecular coordination polymer (SCP) {[SnMe(3)(bpe)] [Ag(CN)2] · 2H(2)O}(n), 1. The structure of 1 consists of cationic {-Sn(Me(3))-bpe-}(+) chains that are neutralized by [Ag(CN)(2)](-) anions. The dicyanoargentate(I) anions present discrete uncoordinated fragments between the cationic chains. The water molecules bind the cationic chains and the anions forming 3D-supramolecular structure through hydrogen bonds. 1 exhibits strong fluorescence in the solid state at room temperature. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to determine the in vitro antitumor effects of the SCP 1 on human breast cancer cell line, T-47D. Cell cycle analysis revealed that the SCP 1 induced apoptosis in T-47D breast cancer cell line. Moreover, in vivo, the SCP 1 showed tumor growth inhibition in rat model that developed mammary carcinoma by 44.8% compared to the vehicle treated control. Thus, the SCP 1 exhibits specific in vivo and in vitro antitumor effects.

Triphenyltin chloride complexes containing bidentate organodiimines as effective antitumor agents

Three triphenyltin chloride complexes, [(Ph3SnCl)2 · (bpy)1.5] (1), [(Ph3SnCl)2.tbpe] (2), and [(Ph3SnCl)2 · bpe] (3), were synthesized by reaction of triphenyltin chloride with 4,4′-bipyridine (bpy), trans-1,2-bis(4-pyridyl)ethylene (tbpe), and 1,2-bis(4-pyridyl)ethane (bpe) in water/acetonitrile. Both 2 and 3 are binuclear; each consists of two Ph3SnCl molecules bridged by the bidentate ligand. Complex 1 consists of two crystallographically independent and chemically different coordination complexes, mononuclear and binuclear in equal proportion. The structures of these complexes were investigated by single-crystal X-ray analysis, elemental analyses, NMR spectroscopy as well as electronic absorption and emission spectroscopy. The three complexes exhibit in vitro antitumor activity against human breast cancer cell line, MCF7.

Structure and catalytic activity of host–guest coordination polymers constructed from copper(I) cyanide nets and 1,4-diaminobutane or 1,5-diaminopentane in the presence of water

The reaction of K3[Cu(CN)4] and 1,4-diaminobutane (DAB) or 1,5-diaminopentane (DAP) in the presence of Me3SnCl affords two monometallic host–guest Cu(I) cyanide polymers: {[H2DAB][Cu4(CN)6]·2H2O}, 1, and{[H2DAP][H3O][Cu4(CN)7]·2H2O}, 2, with exclusion of Me3Sn+ cation. The products were characterized by physicochemical and spectroscopic methods. The structure of 1 consists of two-dimensional hexagonal sheets of (CuCN)n which stack along the b-axis creating honeycomb-shaped channels capable of encapsulating the protonated DAB and water molecules. The structure of 2 consists of a three-dimensional network of [Cu4(CN)7] with large cavities that include H2DAP and water molecules. The rhombic minicycle [Cu2(μ-CN)2] fragments represent the basic building blocks of the network structure of 2. The structures of these compounds are stabilized by hydrogen bonding. The SCP 1 and SCP 2 exhibit good catalytic and photocatalytic activities for the degradation of methylene blue (MB) in the presence of H2O2. The efficiency of recycled SCP 1 and SCP 2 and the mechanism of degradation of MB dye were also investigated.

Structure and Spectral Characterization of Coordination Polymers Constructed by CuCN and Aliphatic Diamines

Abstract The reactions of K3[Cu(CN)4} with aliphatic diamines [urea, ethylenediamine (en) and propane-1,3-diamine (tn)] in presence of Me3SnCl or Ph3SnCl form coordination polymers (CP) with various compositions and architectures. Five coordination polymers; Ph3SnOH, 1,

Supramolecular Self Assembly of [Cu(CN)4]3− Ions with Cationic {Ph3Sn+} Units in the Presence of Neutral Bidentate Ligands

^{3}_{\infty } \left\{ {\left[ {{\text{Cu}}^{\text{II}} \left( {\text{en}} \right)_{2} {\text{H}}_{2} {\text{O}}} \right]\left[ {{\text{Cu}}^{\text{I}}_{2} \left( {\text{CN}} \right)_{4} } \right]} \right\}

Kinetics and mechanism of the heterogeneous catalyzed oxidative decolorization of Acid-Blue 92 using bimetallic metal-organic frameworks.

∞3CuIIen2H2OCu2ICN4, 2,

Structure and Catalytic Activity of New Metal‐Organic Frameworks Based on Copper Cyanide and Quinoline Bases

^{ 3}_{\infty } \left\{ {\left[ {{\text{H}}_{ 2} {\text{tn}}} \right]\left[ {\left( {{\text{Cu}}_{ 2} \left( {\text{CN}} \right)_{ 3} } \right)_{ 2} } \right] \cdot {\text{H}}_{ 2} {\text{O}}} \right\}