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Dive into the research topics where Aida Masmoudi is active.

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Featured researches published by Aida Masmoudi.


Birth Defects Research Part A-clinical and Molecular Teratology | 2015

Association of maternal homocysteine and vitamins status with the risk of neural tube defects in Tunisia: A case–control study

Kaouther Nasri; Mohamed Kacem Ben Fradj; Asma Touati; Mariem Aloui; Nadia Ben Jemaa; Aida Masmoudi; Michèle Véronique Elmay; Souhail Omar; Moncef Feki; Naziha Kaabechi; Raja Marrakchi; Soumeya Siala Gaigi

BACKGROUND This study was conducted to determine whether low folate and vitamin B12 levels, as well as high homocysteine levels in pregnant women are associated with neural tube defects (NTDs) in Tunisia. METHODS A total of 75 NTDs pregnancies and 75 matched controls were included in the study. Their vitamin B12, folate, and red blood cell folate concentrations were measured using a radio-immunoassay kit and total homocysteine concentrations were determined using a fluorescent polarization immunoassay. RESULTS Vitamin B12 and folate concentrations were lower in NTD-affected pregnant women than in controls (respectively, p = 0.009 and p < 0.001). Total homocysteine concentration was significantly higher in the NTDs group than in controls (p = 0.008). In the case group, the folate levels were positively related with vitamin B12 levels (r = 0.54; p < 0.001) and negatively correlated with total homocysteine levels (r = -0.19; p = 0.04). Besides, red blood cell folate levels were positively correlated with folate levels (r = 0.24; p = 0.02) and negatively correlated with total homocysteine levels (r = -0.37; p = 0.001). CONCLUSION Lower concentrations of folate and vitamin B12 are related to the increased risk of NTDs. Both folate and vitamin B12 intake insufficiency could contribute to the increased risk of NTDs. A dietary supplement, combining folate and vitamin B12, might be an effective measure to decrease the NTDs incidence in Tunisia.


Journal of gynecology obstetrics and human reproduction | 2017

Congenital anomalies in Tunisia: Frequency and risk factors

Meriem Aloui; Kaouther Nasri; N. Ben Jemaa; A.M. Ben Hamida; Aida Masmoudi; Soumeya Siala Gaigi; Raja Marrakchi

BACKGROUND Despite the high risk of recurrence of congenital malformations, there are no well-accepted preventive measures in developing countries like Tunisia. It is recommended that thorough epidemiological studies of congenital anomalies in this country are needed. The aim of this study is to assess the frequency and types of congenital anomalies in Tunisia and research some risk factors associated with occurrence of these anomalies. METHODS In this retrospective study, all the fetuses who were autopsied during 21years period from February 1991 to December 2011 (n=9678) at Service of embryofetopathology in the Center of Maternity and Neonatology of Tunis (CMNT) were studied. The classification of malformations was based upon the anatomical system affected. The differences in fetal/maternal characteristics between cases with or without congenital malformations were assessed using Chi2 test. RESULTS Of the all 9678 autopsied fetuses, 4498 (46.47%) were diagnosed as being malformed fetuses. Anomalies of limbs (22.71%) and digestive and abdominal wall defects (14.76%) were mostly detected, followed by congenital brain defects (13.41%) and nephrourologic abnormalities (11.23%). A marked association of parental consanguinity with increased congenital anomalies rates was found (P<10-6, OR=1.89, CI=1.69-2.13). CONCLUSION In Tunisia, surveillance and epidemiological evaluation of congenital anomalies underline the high frequency of these events. This will help to better target congenital anomalies prevention and screening policies in our population.


Pathology Research and Practice | 2015

An increase in spina bifida cases in Tunisia, 2008–2011

Kaouther Nasri; Mohamed Kacem Ben Fradj; Mariem Aloui; Nadia Ben Jemaa; Aida Masmoudi; Michèle Véronique Elmay; Raja Marrakchi; Soumeya Siala Gaigi

BACKGROUND The term spina bifida refers to a group of neural tube defects that result in malformations of the spinal cord and the surrounding vertebrae. Though the etiologies of spina bifida remain largely unknown, several risk factors have been identified, including feto-maternal characteristics. AIM OF THE STUDY To discover possible underlying reasons for the increase of spina bifida and identify intervention targets, an investigation was undertaken comparing spina bifida-affected pregnancy notifications in 2008-2011 with notifications in the period 1991-1994. METHODS Characteristics and outcomes of births with spina bifida and pregnancy characteristics of mothers were recorded in the medical chart. Comparisons of pregnancies affected by a spina bifida in 2008-2011 were made with pregnancies affected by a spina bifida in the period 1991-1994. Statistical analysis was undertaken using Poisson regression and Chi-squared tests. RESULTS From 1991 through 1994, the prevalence of identified spina bifida cases was equal to 0.3/10,000 births compared to 1.6/10,000 births in 2008-2011. This increase was statistically significant (P<0.001). The prevalence of females was equal to 0.45 per 10,000 births over the period 1991-1994 compared to 1.88 per 10,000 births during the period 2008-2011. As for males, the prevalence was equal to 0.16 per 10,000 births in 1991-1994 compared to 1.88 in 2008-2011. The difference was statistically significant (P<0.001) between both genders. A mothers age of over 30 years had significant impact on the emergence of spina bifida (P=0.02, OR=3.93, CI=1.23-12.47). As well as, maternal blood type was a significant risk factor for the appearance of spina bifida (P=0.008). Results also had shown that fetal weight and term, gestity and parity were significant risk factors for the occurrence of spina bifida (P<0.05).In this study, results have been interpreted with caution due to analyses not being adjusted. CONCLUSION This analysis highlighted areas where prevention efforts should be strengthened and surveillance data improved.


Pathology Research and Practice | 2017

Fetopathological examination for the fetuses with Down syndrome in Tunisia: Epidemiological study and associated malformations

Meriem Aloui; Kaouther Nasri; Nadia Ben Jemaa; Meriem Sahraoui; Aida Masmoudi; Dorra Zghal; Dalenda Chelli; Habiba Chaâbouni; Abdel Majid Ben Hamida; Soumeya Siala Gaigi; Raja Marrakchi

BACKGROUND For Down syndrome (DS), traditional epidemiological studies to determine the prevalence, cause, and clinical significance of the syndrome have been conducted over the last 100 years. In Tunisia, the current work is the first in-depth study in epidemiology of DS from fetopathological data. AIM OF THE STUDY The aim of this epidemiological study was to determine the impact of some feto-maternal characteristics in occurrence of DS and to search the frequency of associated congenital malformations with this syndrome. METHODS Our retrospective study was realized for 144 fetuses with DS among 9321 autopsied fetuses in embryo-fetopathological service between 1994 and 2011. RESULTS In our study, the majority of mothers (72.91%) were 35 years and older, with a statistically significant difference (p<10-6, OR=16.7, CI=8.7-32.4). The abnormalities of extremities (31%) were the most common fetal abnormalities followed by facial (23.51%) and digestive abnormalities (19.63%). CONCLUSION One of the main conclusions of this research is that the most common risk factor for DS is maternal age. On the other hand, the type and the frequency of associated congenital anomalies with DS are still controversial.


Journal of Clinical & Medical Genomics | 2017

Usefulness of Fetopathological Examination in the Diagnosis of Skeletal Dysplasias

Sihem Darouich; Nadia Boujelbène; Soumeya Siala Gaigi; Aida Masmoudi

Volume 5 • Issue 1 • 1000e103 J Clin Med Genomics, an open access journal ISSN: 2472-128X The skeletal dysplasias (SD) are the most common of the fetal genetic skeletal disorders. Classification of these conditions is based on clinical, radiological and pathological criteria [1]. The identification of an increasing number of genes involved in these disorders led to consider a molecular classification that groups phenotypically different conditions caused by mutations in the same gene [2]. Thus, the SD are composed of distinct groups of squeletal disorders covering a wide spectrum of gravity. However, this classification is still hybrid because the molecular defects have not yet been identified in all cases of SD [2]. Prenatal imaging can detect early fetal skeletal anomalies of varied severity and prognosis. It can accurately predicts lethality, based on the identification of pulmonary hypoplasia and severe limb shortening, but often raises a


The Pan African medical journal | 2016

Confrontation échographique et fœtopathologie après interruption thérapeutique de grossesse dans une maternité Tunisienne de référence

Mehdi Kehila; Ahmed Halouani; Omar Touhami; Hassine Saber Abouda; Abdeljalil Khlifi; Rim Ben Hmid; Ines Benhassen; Aida Masmoudi; Mohamed Badis Chanoufi

This study aims to evaluate the value of prenatal ultrasound diagnosis by comparing it with the results of the fetopathological examination in case of therapeutic interruption of pregnancy for fetal indication. We conducted a retrospective descriptive and analytical study carried out over a three-year period from January 2013 to December 2015. It involved 66 fetuses autopsied after therapeutic interruption of pregnancy for fetal indication. Fetopathological examination confirmed ultrasound results in 63 cases (95.4%). In 18 cases (27.2%) there was a full match between the results of the prenatal diagnosis and those of the autopsy. Nine percent of fetal malformations were detected in the first trimester. The majority of malformations (72%) were detected in the second timester. Neurological malformations were the most frequent (60%), dominated by hydrocephalus and anencephaly. This study shows that, in our clinical context, even if ultrasound diagnosis is often non-exhaustive, its signs indicating the need for interruptions of pregnancy are correct. Fetopathological examination is used, in this case, to detect unknown malformations, making it possible to specify the diagnosis and to implement a strategy for subsequent pregnancies.


Case Reports in Perinatal Medicine | 2016

A fetopathological and clinical study of the Dandy-Walker malformation and a literature review

Tanya Kitova; Borislav Kitov; Hristo Zhelyazkov; Denis Milkov; Dalenda Chelli; Aida Masmoudi; Soumeya Siala Gaigi

Abstract Aim: The Dandy-Walker malformation is a rare abnormality of the central nervous system pertaining to the group of cystic malformations. The frequency of occurrence of the malformation ranges from 1:800 to 35,000 live births. The aim of this study is to investigate the Dandy-Walker malformation in two cases – one by autopsy after abortion due to medical indications during the 25th gestational week at The Clinic of Embryo and Fetopathology, Center for Maternity and Neonatology, Tunis, Tunisia, and another case of a 1-year-old infant diagnosed with an acute internal hydrocephalus at The Clinic of Neurosurgery, Medical University Plovdiv, Bulgaria, and to compare the results with those in the literature. Results: Both cases are of an isolated Dandy-Walker malformation without any associated abnormalities of the central nervous system and other organs and systems. After the placement of a ventriculoperitoneal shunt in the second case, the child’s condition was greatly improved. Conclusion: The question arises whether the prenatal diagnosis of an isolated Dandy-Walker malformation is an indication for pregnancy termination, and who and after what examinations has the right to make this decision, given the favorable outcome after surgical treatment.


Central European Journal of Medicine | 2014

A fetus with meckel-gruber syndrome associated with isomerism

Tanya Kitova; Kristina Kilova; Borislav Kitov; Aida Masmoudi; Denis Milkov; Soumeya Siala Gaigi

Abstract. Meckel-Gruber syndrome (MKS) is an autosomal recessive lethal malformation. As far as we know, the rate of incidence for the syndrome is 0.02 per 10,000 births. It is estimated that Meckel-Gruber syndrome accounts for 5% of all neural tube defects in Finland. Objective. The aim of this study is to present a case of a fetus with Meckel-Gruber syndrome associated with complete left isomerism. Method. The fetus was obtained after medical interruption of the pregnancy during the fifteenth gestational week. The mother was 36 years old and in a consanguineous marriage. The antenatal ultrasound examination revealed a polymalformative syndrome, leading to a postmortem examination. The fetopathological study of the fetus was conducted at the Centre for Maternity and Neonatology, Tunis, Tunisia, in 2008. Results. The female fetus had a significantly deformed ballooning abdomen, pes equinovarus, flexion of the wrist and a total posterior cleft palate. The central nervous system abnormalities were occipital encephalocele, cystic dilatation of the fourth ventricle, agenesis of corpus callosum and hydrocephalus. The study of the internal organs found dextrocardia, irregular lobulation of the lungs, left isomerism, and polysplenia. The microscopic examination revealed bilateral cystic dilation of the kidneys, fibrous proliferation of the liver and ectasic dilatation of the billiary ducts, representing a ductal plate malformation of the liver. Conclusion. The case is diagnosed with Meckel-Gruber syndrome associated with complete left isomerism, cleft palate and possibly Dandy-Walker syndrome.


Central European Journal of Medicine | 2013

Maternal factors and associated anomalies in NTD fetuses from Tunisia

Tanya Kitova; Emiliya Karaslavova; Aida Masmoudi; Soumeya Siala Gaigi

Aim of the studyTo determine the impact of maternal age, consanguinity, season of conception and variation in the amount of amniotic fluid for the appearance of anomalies associated with neural tube defects (NTDs).Materials and methods150 NTD fetuses, a result from autopsies (macroscopic autopsy; microscopic study of biopsy fragments; macro and microscopic brain examination), have been examined during a period of three years (01.2006, 01.2009), in the Clinic of Fetopathology, at the Center of Maternity and Neonatology — Tunisia.ResultsAnomalies associated with NTDs occur three times more often in pregnancies with an abnormal amount of amniotic fluid. Also, their likelihood of cardiovascular and reproductive system anomalies is increased four times. Nearly 80% of the NTD fetuses conceived during the autumn-winter period have acrania. Women older than 35, are twice more likely to have underweight children and children with defects of the digestive system and hand. They are also three times more likely to have fetuses with endocrine system abnormalities. Anomalies incompatible with life occur twice as often in consanguineous unions.ConclusionThe mother’s age, consanguinity, season of conception, and variation in the amount of amniotic fluid have considerable impact on the emergence of associated anomalies in fetuses with NTDs.


Pathology Research and Practice | 2014

Epidemiology of neural tube defect subtypes in Tunisia, 1991-2011.

Kaouther Nasri; Mohamed Kacem Ben Fradj; Thouraya Hamdi; Mariem Aloui; Nadia Ben Jemaa; Saber Nahdi; Refka Guesmi; Aida Masmoudi; Michèle Véronique Elmay; Raja Marrakchi; Soumeya Siala Gaigi

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Tanya Kitova

Medical University Plovdiv

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Denis Milkov

Medical University Plovdiv

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Borislav Kitov

Medical University Plovdiv

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