Aifeng Ren

Changes in thalamic connectivity in the early and late stages of amnestic mild cognitive impairment: a resting-state functional magnetic resonance study from ADNI.

We used resting-state functional magnetic resonance imaging (fMRI) to investigate changes in the thalamus functional connectivity in early and late stages of amnestic mild cognitive impairment. Data of 25 late stages of amnestic mild cognitive impairment (LMCI) patients, 30 early stages of amnestic mild cognitive impairment (EMCI) patients and 30 well-matched healthy controls (HC) were analyzed from the Alzheimer’s disease Neuroimaging Initiative (ADNI). We focused on the correlation between low frequency fMRI signal fluctuations in the thalamus and those in all other brain regions. Compared to healthy controls, we found functional connectivity between the left/right thalamus and a set of brain areas was decreased in LMCI and/or EMCI including right fusiform gyrus (FG), left and right superior temporal gyrus, left medial frontal gyrus extending into supplementary motor area, right insula, left middle temporal gyrus (MTG) extending into middle occipital gyrus (MOG). We also observed increased functional connectivity between the left/right thalamus and several regions in LMCI and/or EMCI including left FG, right MOG, left and right precuneus, right MTG and left inferior temporal gyrus. In the direct comparison between the LMCI and EMCI groups, we obtained several brain regions showed thalamus-seeded functional connectivity differences such as the precentral gyrus, hippocampus, FG and MTG. Briefly, these brain regions mentioned above were mainly located in the thalamo-related networks including thalamo-hippocampus, thalamo-temporal, thalamo-visual, and thalamo-default mode network. The decreased functional connectivity of the thalamus might suggest reduced functional integrity of thalamo-related networks and increased functional connectivity indicated that aMCI patients could use additional brain resources to compensate for the loss of cognitive function. Our study provided a new sight to understand the two important states of aMCI and revealed resting-state fMRI is an appropriate method for exploring pathophysiological changes in aMCI.

Altered effective connectivity patterns of the default mode network in Alzheimer's disease: an fMRI study.

The aim of this work is to investigate the differences of effective connectivity of the default mode network (DMN) in Alzheimers disease (AD) patients and normal controls (NC). The technique of independent component analysis (ICA) was applied to identify DMN components and multivariate Granger causality analysis (mGCA) was used to explore an effective connectivity pattern. We found that: (i) connections in AD were decreased than those in NC, in terms of intensity and quantity. Posterior cingulated cortex (PCC) exhibited significant activity in NC as it connected with most of the other regions within the DMN. Besides, the PCC was the convergence center which only received interactions from other regions; (ii) right inferior temporal cortex (rITC) in the NC exhibited stronger interactions with other regions within the DMN compared with AD patients; and (iii) interactions between medial prefrontal cortex (MPFC) and bilateral inferior parietal cortex (IPC) in the NC were weaker than those in AD patients. These findings may implicate a brain dysfunction in AD patients and reveal more pathophysiological characteristics of AD.

Functional brain network analysis of schizophrenic patients with positive and negative syndrome based on mutual information of EEG time series

Abstract Schizophrenia (SZ) is categorized as positive SZ and negative SZ in terms of the predominant symptom. In this study, we proposed the hypothesis that positive SZ had more information interaction and negative SZ had less information interaction between brain regions compared with normal controls. To verify the hypothesis, firstly, we recorded and preprocessed the electroencephalogram data with 32 electrodes from 28 schizophrenic patients (14 with positive symptoms and 14 with negative symptoms) and 14 normal controls. Then, mutual information (MI) was used to construct the functional brain networks, and these networks were analyzed by the method of graph theory. We calculated and analyzed several network metrics which reflected the ability of the information processing in the network. The results showed smaller clustering coefficient, larger average characteristic path length, lower global efficiency, lower local efficiency and smaller degrees in SZ functional brain networks compared with normal controls. We conclude that there are fewer information interactions in SZ patients than that in normal controls, while positive SZ has more information interactions than negative SZ does, and patients tend to have slower and less efficient information transfer between brain regions. These findings have a great significance to deeply understand the pathogenesis of SZ.

Buried Object Sensing Considering Curved Pipeline

This letter presents design and implementation of a system solution, where light weight wireless devices are used to identify a moving object within underground pipeline for maintenance and inspection. The devices such as transceiver operating at S-band are deployed for underground settings. Finer-grained channel information in conjunction with leaky-wave cable (LWC) detects any moving entity. The processing of the measured data over time is analyzed and used for reporting the disturbances. Deploying an LWC as the receiver has benefits in terms of a wider coverage area, covering blind and semiblind zones. The system fully exploits the variances of both amplitude and phase information of channel information as the performance indicators for motion detection. The experimental results demonstrate greater level of accuracy.

Monitoring of atopic dermatitis using leaky coaxial cable

In our daily life, inadvertent scratching may increase the severity of skin diseases (such as atopic dermatitis etc.). However, people rarely pay attention to this matter, so the known measurement behaviour of the movement is also very little. Nevertheless, the behaviour and frequency of scratching represent the degree of itching, and the analysis of scratching frequency is helpful to the doctors clinical dosage. In this Letter, a novel system is proposed to monitor the scratching motion of a sleeping human body at night. The core device of the system is just a leaky coaxial cable (LCX) and a router. Commonly, LCX is used in the blind field or semi-blindfield in wireless communication. The new idea is that the leaky cable is placed on the bed, and then the state information of physical layer of wireless communication channels is acquired to identify the scratching motion and other small body movements in the human sleep process. The results show that it can be used to detect the movement and its duration. Channel state information (CSI) packet is collected by card installed in the computer based on the 802.11n protocol. The characterisation of the scratch motion in the collected CSI is unique, so it can be distinguished from the wireless channel amplitude variation trend.

Sparsity-Inspired Nonparametric Probability Characterization for Radio Propagation in Body Area Networks

Parametric probability models are common references for channel characterization. However, the limited number of samples and uncertainty of the propagation scenario affect the characterization accuracy of parametric models for body area networks. In this paper, we propose a sparse nonparametric probability model for body area wireless channel characterization. The path loss and root-mean-square delay, which are significant wireless channel parameters, can be learned from this nonparametric model. A comparison with available parametric models shows that the proposed model is very feasible for the body area propagation environment and can be seen as a significant supplement to parametric approaches.

Adaptive Interference Cancellation of ECG Signals

As an important biological signal, electrocardiogram (ECG) signals provide a valuable basis for the clinical diagnosis and treatment of several diseases. However, its reference significance is based on the effective acquisition and correct recognition of ECG signals. In fact, this mV-level weak signal can be easily affected by various interferences caused by the power of magnetic field, patient respiratory motion or contraction, and so on from the sampling terminal to the receiving and display end. The overlapping interference affects the quality of ECG waveform, leading to the false detection and recognition of wave groups, and thus causing misdiagnosis or faulty treatment. Therefore, the elimination of the interference of the ECG signal and the subsequent wave group identification technology has been a hot research topic, and their study has important significance. Based on the above, this paper introduces two improved adaptive algorithms based on the classical least mean square (LMS) algorithm by introducing symbolic functions and block-processing concepts.

Patterns-of-Life Aided Authentication

Wireless Body Area Network (WBAN) applications have grown immensely in the past few years. However, security and privacy of the user are two major obstacles in their development. The complex and very sensitive nature of the body-mounted sensors means the traditional network layer security arrangements are not sufficient to employ their full potential, and novel solutions are necessary. In contrast, security methods based on physical layers tend to be more suitable and have simple requirements. The problem of initial trust needs to be addressed as a prelude to the physical layer security key arrangement. This paper proposes a patterns-of-life aided authentication model to solve this issue. The model employs the wireless channel fingerprint created by the user’s behavior characterization. The performance of the proposed model is established through experimental measurements at 2.45 GHz. Experimental results show that high correlation values of 0.852 to 0.959 with the habitual action of the user in different scenarios can be used for auxiliary identity authentication, which is a scalable result for future studies.

Biometric Behavior Authentication Exploiting Propagation Characteristics of Wireless Channel

Massive expansion of wireless body area networks (WBANs) in the field of health monitoring applications has given rise to the generation of huge amount of biomedical data. Ensuring privacy and security of this very personal data serves as a major hurdle in the development of these systems. An effective and energy friendly authentication algorithm is, therefore, a necessary requirement for current WBANs. Conventional authentication algorithms are often implemented on higher levels of the Open System Interconnection model and require advanced software or major hardware upgradation. This paper investigates the implementation of a physical layer security algorithm as an alternative. The algorithm is based on the behavior fingerprint developed using the wireless channel characteristics. The usability of the algorithm is established through experimental results, which show that this authentication method is not only effective, but also very suitable for the energy-, resource-, and interface-limited WBAN medical applications.

Authentication in Millimeter-Wave Body-Centric Networks Through Wireless Channel Characterization

Advent of 5G technologies has ensued in massive growth of body-centric communications (BCCs), especially at millimeter-wave (mm-wave) frequencies. As a result, the portable/handheld terminals are becoming more and more “intelligent” but not without the cost of being less secure. Improved authentication measures need to be explored, as effective identity authentication is the first level of security in these devices. This paper presents a novel keyless authentication method exploiting wireless channel characteristics. Human palm has distinct transmission coefficient (S21) for each of the users and is used for in vivo fingerprint identification in this paper. A detailed channel modeling using data acquisition from real environment and empirical approach is adopted to evaluate the usability of this method. The results show that this method can provide a secure operation for the mm-wave 5G BCCs.