Aimee L. Leonard
New York University
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Featured researches published by Aimee L. Leonard.
Mayo Clinic Proceedings | 2006
Deborah L. Cummins; Jordan M. Cummins; Hardin Pantle; Michael A. Silverman; Aimee L. Leonard; Arjun Chanmugam
Skin cancer has become the most common neoplasm in the United States. With early diagnosis and appropriate management, most skin cancers have an overall 5-year survival rate of 95%. Cutaneous malignant melanoma (CMM), however, has a significantly higher morbidity and mortality, resulting in 65% of all skin cancer deaths. Although the long-term survival rate for patients with metastatic melanoma is only 5%, early detection of CMM carries an excellent prognosis, with surgical excision often being curative. Primary care physicians can play a critical role in reducing morbidity and mortality from CMM by recognizing patients at risk, encouraging the adoption of risk-reducing behaviors, and becoming adept at identifying suspicious lesions.
Journal of Cutaneous Pathology | 2012
Wang L. Cheung; Rishi Patel; Aimee L. Leonard; Bahar Firoz; Shane A Meehan
Amelanotic melanoma can have a varied appearance both clinically and microscopically. Here, we present our experiences with 75 cases of amelanotic melanoma defined clinically as a non‐pigmented lesion and histopathologically as a tumor lacking significant melanization. We evaluated microscopic features such as morphology, mitotic count, nuclear atypia and presence of solar elastosis. Our amelanotic melanomas exhibited the following morphology: epitheloid (72%), spindled (18.7%) or desmoplastic (5.3%). In addition, we obtained patient information and clinical presentations on most of the cases (74/75; 98.7%) and follow‐up data on 40% (30/75) of the cases. The majority of amelanotic melanomas in men were found on the trunk (13/45; 29%), head and neck (12/45; 26.7%), and lower limb (13/45; 29%) and in women were found on the lower limb (12/30; 40%), upper limb (10/30; 33.3%) and head and neck (6/30; 20%). In addition, we found that an increase in mitotic index correlated with worse survival (p < 0.026), whereas there were no differences in survival for other pathological features, such as nuclear atypia or solar elastosis. Furthermore, in cases with available tissue, all amelanotic melanoma expressed microphthalmia‐associated transcription factor and tyrosinase, suggesting that the tumor cells retained melanocytic lineage and an enzyme in melanin formation, respectively. As the occurrence of amelanotic melanoma and the expression melanoma markers were similar to pigmented melanoma, we favor that amelanotic melanoma represents a subtype of melanoma rather than poorly differentiated or de‐differentiated melanoma.
Journal of The American Academy of Dermatology | 2007
Aimee L. Leonard; Shane A Meehan; David Ramsey; Lance H. Brown; Filiz Sen
Journal of The American Academy of Dermatology | 2007
Aimee L. Leonard; C. William Hanke
Dermatologic Surgery | 2007
C. William Hanke; Aimee L. Leonard; Amy J. Reed
Journal of The American Academy of Dermatology | 2013
C. William Hanke; Ronald L. Moy; Randall K. Roenigk; Henry H. Roenigk; James M. Spencer; Emily P. Tierney; Cynthia L. Bartus; Robert M. Bernstein; Marc D. Brown; Mariano Busso; Alastair Carruthers; Jean Carruthers; Omar A. Ibrahimi; Arielle N.B. Kauvar; Kathryn M. Kent; Nils Krueger; Marina Landau; Aimee L. Leonard; Stephen Mandy; Thomas E. Rohrer; Neil S. Sadick; Luitgard Wiest
Journal of Drugs in Dermatology | 2006
Aimee L. Leonard; Hanke Cw
Dermatology Online Journal | 2003
Aimee L. Leonard; Irwin M. Freedberg
Journal of Drugs in Dermatology | 2006
Aimee L. Leonard; Hanke Cw
Journal of Drugs in Dermatology | 2003
Aimee L. Leonard