Ajay Kaja

Serum hyperchloremia as a risk factor for acute kidney injury in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention

A high serum chloride concentration has been associated with the development of acute kidney injury in critically ill patients. However, the association between hyperchloremia and acute kidney injury (AKI) in patients admitted with ST-segment elevation myocardial infarction (STEMI) treated with percutaneous coronary intervention (PCI) is unknown. A retrospective analysis of consecutive patients admitted with the diagnosis of STEMI and treated with PCI was performed. Subjects were classified as having hyper- or normochloremia based upon their admission serum chloride level. Multivariable logistic regression analyses were employed for the primary and secondary outcomes. The primary analysis evaluated whether high serum chloride on admission was associated with the development of AKI after adjusting for age, diabetes mellitus, admission systolic blood pressure, contrast volume used during angiography, Killip class, and need for vasopressor therapy or intraaortic balloon pump. The secondary analyses evaluated whether high serum chloride was associated with sustained ventricular tachycardia or fibrillation. Of 291 patients (26.1% female, mean age of 59.9 ± 12.6 years, and mean body mass index of 29.3 ± 6.1 kg/m2), 25 (8.6%) developed AKI. High serum chloride on admission did not contribute significantly to the development of AKI (odds ratio, 95%; confidence interval, 0.90 to 1.24). In addition, serum chloride on admission was not significantly associated with sustained ventricular tachycardia or fibrillation after adjusting for demographic and clinical covariates. In conclusion, our study demonstrated no association between baseline serum hyperchloremia and an increased risk of AKI in patients admitted with STEMI treated with PCI.

SYNTAX SCORE AND ITS IMPACT ON LONG TERM OUTCOMES OF CORONARY REVASCULARIZATION: A META-ANALYSIS AND META-REGRESSION

We sought to compare the long term outcomes of Percutaneous Coronary Revascularization (PCI) Vs CABS (Coronary Artery Bypass Surgery) for coronary stenoses with low (0-22) & intermediate (23-32) SYNTAX score PubMed & Web of Science were searched up to 15th October 2015 for studies comparing long

ZOTAROLIMUS ELUTING STENT VERSUS EVEROLIMUS ELUTING STENT IN PERCUTANEOUS CORONARY INTERVENTION: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS

Zotarolimus eluting stents (ZES) and Everolimus eluting stents (EES) with durable polymer are the most commonly used second and third generation drug-eluting stents (DES) during percutaneous coronary revascularization (PCI). Previously conducted randomized (RCTs) and observational trials have shown

VENTRICULAR ARRHYTHMIAS IN HOSPITALIZED HFPEF PATIENTS

Non sustained Ventricular arrhythmias (NSVA) are frequently noted in patients admitted with acute decompensated diastolic heart failure. However, the long term predictive value of NSVA in this setting is unclear. The objective was to elucidate the burden of ventricular arrhythmias in patients

UTILITY OF IODINE-123-METAIODOBENZYLGUANIDINE IMAGING IN PREDICTING CLINICALLY RELEVANT VENTRICULAR ARRHYTHMIAS IN PATIENTS WITH SYSTOLIC HEART FAILURE: A SYSTEMATIC REVIEW

Left ventricular ejection fraction remains the most useful predictor of sudden death and clinically relevant ventricular arrhythmias (CRVA), making it the cornerstone of current criteria for selecting implantable defibrillator (ICD) candidates. However, the utility of new tools like Iodine-123-