Ajeya P. Joshi
Boston Children's Hospital
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Journal of Pediatric Orthopaedics | 2010
Norman Ramirez; John M. Flynn; John B. Emans; Randal R. Betz; John T. Smith; Nigel Price; Tricia St. Hilaire; Ajeya P. Joshi; Robert M. Campbell
Background Spondylocostal dysplasia (SCD) constitutes a heterogeneous patient group with multiple vertebral formations and segmentation defects of the entire spine, with asymmetric rib malformations. Respiratory failure has been reported in spondylocostal dysplasia secondary to thoracic insufficiency syndrome. The vertical expandable prosthetic titanium rib (VEPTR) reconstructs the chest wall to address the thoracic insufficiency seen in this patient population. The purpose of this study is to evaluate spinal deformity correction and respiratory function outcomes in a spondylocostal dysplasia population treated with VEPTR. Methods A cohort of 20 patients with spondylocostal dysplasia and 2-year follow-up were evaluated from a multicenter IDE study of 214 patients who had surgery with the VEPTR device. Data collected included gender, nonskeletal malformations, age at surgery, number of procedures, estimated blood loss, length of stay, and surgical time. Clinical and radiographic parameters were collected, and respiratory function was assessed. Results In 14 of 20 patients (70%), spinal deformity was controlled evidenced by a decrease of the initial Cobb coronal angle at last follow-up. Fourteen patients (70%) maintained their oxygen level throughout treatment. At preoperative and last evaluation, assisted ventilation rating (AVR) scores showed that 5 patients improved their level of ventilation and 14 patients maintained their AVR level at room air. One patient decreased his level from supplemental oxygen to night ventilation. Mean thoracic spinal length (growth) by year was 0.82 cm. No mortality occurred in this group of patients. Conclusions VEPTR implantation in SCD allows continued thoracic spine growth while controlling progressive spine deformity. The improved AVR ratings after surgery suggest a beneficial effect on the natural history of TIS in this population. Mortality and complication rate seem acceptable in this high-risk population of SCD patients. Level of Evidence Therapeutic study, Level IV, (case series, no comparison group).
Journal of Bone and Joint Surgery, American Volume | 2014
Joshua G. Karlin; Megan K. Roth; Vishwas Patil; Davin Cordell; Hope Trevino; James W. Simmons; Robert M. Campbell; Ajeya P. Joshi
BACKGROUND Jarcho-Levin syndrome represents a spectrum of clinical and radiographic irregularities including abnormal vertebral segmentation or formation defects, rib deformities, and short-trunk dwarfism. These abnormalities cause reduced thoracic capacity for lung development, resulting in thoracic insufficiency syndrome. In the present study, we reviewed outcome measures related to scoliotic curve correction, thoracic growth, and respiratory function following VEPTR treatment in patients with Jarcho-Levin syndrome. METHODS Twenty-nine patients with Jarcho-Levin syndrome, subclassified as spondylocostal dysostosis (SCD) or spondylothoracic dysplasia (STD), were treated with VEPTR expansion thoracoplasty and followed for at least two years since the initial implantation. Spinal and respiratory measures were collected prior to the initial VEPTR implantation, immediately after implantation, and at the most recent follow-up. RESULTS VEPTR treatment was associated with improved clinical respiratory function and with increases in thoracic height (by 50% in the SCD group and 42% in the STD group) and thoracic width (by 37% in the SCD group and 28% in the STD group). VEPTR treatment resulted in scoliosis curve correction (improvement in the Cobb angle of 41% [22°] in the SCD group and 26% [3.7°] in the STD group) and in improved thoracic symmetry in patients with SCD. Patients with SCD displayed increased lumbar lordosis, and both groups of patients developed increased thoracic kyphosis approaching normal. CONCLUSIONS VEPTR treatment improved thoracic symmetry, controlled spinal deformity, and was associated with improved clinical respiratory function.
Journal of Pediatric Orthopaedics | 2015
Aaron O’Brien; Megan K. Roth; Hariharan Athreya; Kent A. Reinker; William Koeck; Vishwas Patil; Hope Trevino; James W. Simmons; Ajeya P. Joshi; Melvin D. Smith; Robert M. Campbell
Background: Jeune syndrome (JS) often results in lethal thoracic insufficiency syndrome. Since 1991, vertical expandable prosthetic titanium rib Dynamic PosteroLateral Expansion Thoracoplasty was used at our institution for treatment of JS. This study assesses the safety and efficacy of this procedure. Methods: Twenty-four JS patients were treated, 2 lost to follow-up, 17 with a minimum of 2-year follow-up retrospectively reviewed for clinical course: Assisted Ventilation Rate, respiratory rate, capillary blood gases, pulmonary function testings, and complications. Upright anteroposterior/lateral radiographs were measured for Cobb angle, kyphosis, lordosis, thoracic width, and thoracic/lumbar spinal height. Computed tomography scan lung volumes were obtained in 12 patients. Results: Mean age at initial implant was 23 months (7 to 62 mo) with an average 8.4 years (2.3 to 15.6 y) of follow-up. Average chest width increased from 121 to 168 mm at follow-up (P<0.001). Preoperatively, 7/17 (41%) patients had scoliosis. The remainder developed scoliosis during treatment, 8 requiring additional implants. Thoracic and lumbar spinal height was normal preoperatively and stayed normal during treatment. Thoracic kyphosis/lumbar lordosis was stable. Average computed tomography scan total lung volumes increased 484 to 740 mm3 (P<0.001), and Assisted Ventilation Rate status tended to improve (P=0.07). Average forced vital capacity was 34% predicted at first test and 27% predicted at last follow-up. Early demise after surgery was common with multisystem disease. Mean respiratory rate decreased from 35 to 24 bpm at last follow-up (P<0.05). Survival rate of the 22 patients was 68%. Migration of the rib cradles/titanium slings occurred in 12 patients, superficial infections in 5 patients, deep infections in 4 patients, and wound dehiscence in 5 patients. Infection rate was 4.6% per procedure. Conclusions: The survival rate in JS with surgery was nearly 70% (compared with 70% to 80% mortality without treatment) with less ventilator dependence. Both C1 stenosis and scoliosis are common in JS. Spinal height in JS is normal. Complications are frequent, but tolerable in view of the clinical gains and increase in survival. Level of Evidence: Level IV—retrospective therapeutic case series.
Jbjs Essential Surgical Techniques | 2015
Ajeya P. Joshi; Megan K. Roth; James W. Simmons; Felix R. Shardonofsky; Robert M. Campbell
Overview Introduction Although surgical treatment of spondylothoracic dysplasia (STD) is controversial, we have found that an expansion thoracoplasty using a Vertical Expandable Prosthetic Titanium Rib (VEPTR; DePuy Synthes) results in favorable outcomes, including 100% survivability (at an average follow-up of 6.2 years), increased thoracic spinal length, and decreased requirements for ventilation support. Step 1: Preoperative Preparation Make anteroposterior and lateral radiographs of the spine. Step 2: Position the Patient for the Procedure The patient is placed in the prone position. Step 3: The Incision A curvilinear skin incision is made, starting proximally between the spine and the medial edge of the scapula. Step 4: The Osteotomy Perform the v-osteotomy. Step 5: Placement of the VEPTR Device A number-4 VEPTR-I device is wedged in, starting laterally within the osteotomy sites, wedging the osteotomies apart, distracting the superior ribs proximally and the inferior ribs distally, lengthening the hemithorax, and stopping approximately at the posterior axillary line, when there is maximum stress on the superior and inferior ribs, to avoid fracture, and the lamina spreaders are then removed. Step 6: Wound Closure Insert drains and local anesthetic catheters and close the wound. Step 7: Expansion and Replacement Procedures Lengthen the devices with the standard VEPTR technique of limited 3-cm incisions every three to six months. Results VEPTR treatment in patients with STD is associated with increased thoracic spine height and reduced thoracic width-to-height ratio, suggesting a greater gain in height than in width. What to Watch For Indications Contraindications Pitfalls & Challenges
Journal of Immigrant and Minority Health | 2014
Krista L. Kilpadi; R. ElDabaje; James E. Schmitz; Benjamin Ehler; T. A. Thames; Ajeya P. Joshi; James W. Simmons; Joel E. Michalek; Roberto J. Fajardo
Journal of Children's Orthopaedics | 2014
Michael P. Glotzbecker; Sumeet Garg; Behrooz A. Akbarnia; Michael G. Vitale; Tricia St Hillaire; Ajeya P. Joshi
European Journal of Orthopaedic Surgery and Traumatology | 2016
Ryoji Tauchi; Taichi Tsuji; Patrick J. Cahill; John M. Flynn; Michael P. Glotzbecker; Ron El-Hawary; John Heflin; Shiro Imagama; Ajeya P. Joshi; Ayato Nohara; Norman Ramirez; David P. Roye; Toshiki Saito; Jeffrey R. Sawyer; John T. Smith; Noriaki Kawakami
Spine deformity | 2018
Jonathan D. Crews; Marina Mina; Eric Johnson; Janette Guillen; James W. Simmons; Ajeya P. Joshi
Journal of Pediatric Orthopaedics | 2018
Gregory J. Redding; Heidi Hurn; Klane K. White; Viviana Bompadre; Julia Emerson; R. Zachary Garza; Kendall Anigian; John A. Waldhausen; Walter F. Krengel; Ajeya P. Joshi
Spine deformity | 2015
Gregory J. Redding; Heidi Hurn; Klane K. White; Viviana Bompadre; Julia Emerson; John Wauldhausen; Wally Krengel; Ajeya P. Joshi