Akhilesh Gupta

Formulation and Evaluation of Floating Matrix Tablets of Acyclovir using 32 Factorial Design

Floating Drug Delivery Systems (FDDS) have a bulk density lower than gastric fluids and thus remain buoyant in the stomach for a prolonged period of time, without affecting the gastric emptying rate. While the system is floating on the gastric contents, the drug is released slowly at a desired rate from the system. These floating tablets mainly prepared for reduction of lag time and release the drug up to 12 hours and may also increase the bioavailability of the drugs by utilizing the drug to full extent avoiding unnecessary frequency of dosing. The study included formulation of floating tablets using polymers like Hydroxy propyl methyl cellulose K15M, PVP K30, Sodium bicarbonate, Xanthan-Gum, Guar-gum and microcrystalline cellulose as matrix forming agents. The tablets were directly compressed using Lab Press multi station rotary punching machine. FTIR and DSC-TGA studies conformed that there was no incompatibility between the polymers and the drug. Tablet preformulation parameters were within the Pharmacopoeias limit. Tablet showed zero lag time, continuance of buoyancy for >12 h. In vivo X-ray studies depicted that tablets continued to float in the GIT for 12 h. The in vitro drug release pattern of Acyclovir floating tablets was fitted to different kinetic models which showed highest regression for zero order kinetics with Koresmeyer-peppasand most of the formulations followed Nonfickian diffusion.

Clinical Research and Therapeutic Importance of Dietary Supplement L-Carnitine: Review

Carnitine, derived from an amino acid, is found in nearly all cells of the body. Its name is derived from the Latin carnus or flesh, as the compound was isolated from meat. Carnitine is the generic term for a number of compounds that include L-carnitine, acetyl-L-carnitine, and propionyl-L-carnitine. Carnitine plays a critical role in energy production. It transports long-chain fatty acids into the mitochondria so they can be oxidized to produce energy. It also transports the toxic compounds generated out of this cellular organelle to prevent their accumulation. Given these key functions, carnitine is concentrated in tissues like skeletal and cardiac muscle that utilize fatty acids as a dietary fuel. The body makes sufficient carnitine to meet the needs of most people. For genetic or medical reasons, some individuals (such as preterm infants), cannot make enough, so for them carnitine is a conditionally essential nutrient. Animal products like meat, fish, poultry, and milk are the best sources. In general, the redder the meat, the higher its carnitine content. Dairy products contain carnitine primarily in the whey fraction. Adults eating mixed diets that include red meat and other animal products obtain about 60–180 milligrams of carnitine per day. Vegans get considerably less (about 10–12 milligrams) since they avoid animal derived foods. Most (54–86%) dietary carnitine is absorbed in the small intestine and enters the bloodstream. L-carnitin proved its medicinal importance but in the present era it is neglected. In this review I am trying to explain therapeutic importance of L-carnitin.

Clinical Importance of Aloe Vera:Review

John Goodyew translated first reference from term ‘Dioscorides Medical treatise De Materia Medica’ into English terminology as use of Aloe vera in A.D. 1655; moreover, in early 1800s it used as laxative whereas in the mid 1930s successful treatment was introduced for chronic and severe radiation dermatitis. Since, several cultures of the history have been showed impression of foot print for use of Aloe vera, major includes Greece, Egypt, India, Mexico, Japan and China. Egyptian queens Nefertiti and Cleopatra regularly involved it in their beauty regimes whereas Alexander the Great, and Christopher Columbus used it to treat soldiers’ wounds. Aloe vera is well known plant not only in tribal community but modern lookout also make it therapeutic important. Since it is used in Ayurvedic, Homeopathic and Allopathic medicine because various research support that it contains vitamins, minerals, enzymes, amino acids, natural sugar and other bioactive compounds. Although therapeutic use of Aloe vera covered wide range of activity major includes emollient, purgative, antimicrobial, anti inflammatory, antioxidant, aphrodisiac, anti-helmenthic, antifungal, antiseptic and cosmetic, its benefits so myriad and astounding that no part in human body remains uninfluenced by its healing touch; all these make it plant of wonder. The modern therapeutic approach for beauty enhancer also list Aloe vera as most favorable plant in cosmetic industries. In this review we are trying to approach and underlying every possible corner associated with medicinal use of Aloe vera.