Aki Kamijo
University of Tokyo
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Publication
Featured researches published by Aki Kamijo.
Journal of Immunology | 2009
Kyoko Haraguchi; Takahiro Suzuki; Noriko Koyama; Keiki Kumano; Fumio Nakahara; Akihiko Matsumoto; Yasuhisa Yokoyama; Mamiko Sakata-Yanagimoto; Shigeo Masuda; Tsuyoshi Takahashi; Aki Kamijo; Koki Takahashi; Minoko Takanashi; Yoshiki Okuyama; Koji Yasutomo; Seiji Sakano; Hideo Yagita; Mineo Kurokawa; Seishi Ogawa; Shigeru Chiba
The development of NK cells from hematopoietic stem cells is thought to be dependent on IL-15. In this study, we demonstrate that stimulation of human cord blood CD34+ cells by a Notch ligand, Delta4, along with IL-7, stem cell factor, and Fms-like tyrosine kinase 3 ligand, but no IL-15, in a stroma-free culture induced the generation of cells with characteristics of functional NK cells, including CD56 and CD161 Ag expression, IFN-γ secretion, and cytotoxic activity against K562 and Jurkat cells. Addition of γ-secretase inhibitor and anti-human Notch1 Ab to the culture medium almost completely blocked NK cell emergence. Addition of anti-human IL-15-neutralizing Ab did not affect NK cell development in these culture conditions. The presence of IL-15, however, augmented cytotoxicity and was required for a more mature NK cell phenotype. CD56+ cells generated by culture with IL-15, but without Notch stimulation, were negative for CD7 and cytoplasmic CD3, whereas CD56+ cells generated by culture with both Delta4 and IL-15 were CD7+ and cytoplasmic CD3+ from the beginning and therefore more similar to in vivo human NK cell progenitors. Together, these results suggest that Notch signaling is important for the physiologic development of NK cells at differentiation stages beyond those previously postulated.
Diamond and Related Materials | 2005
T. Saito; Terumitsu Hasebe; Satoshi Yohena; Y. Matsuoka; Aki Kamijo; Koki Takahashi; Tetsuya Suzuki
Annals of Oncology | 2006
Eriko Nitta; Kouji Izutsu; Tomohiko Sato; Yasunori Ota; Kengo Takeuchi; Aki Kamijo; Koki Takahashi; Kumi Oshima; Yoshinobu Kanda; Shigeru Chiba; Toru Motokura; Mineo Kurokawa
Diamond and Related Materials | 2007
Terumitsu Hasebe; T. Ishimaru; Aki Kamijo; Yukihiro Yoshimoto; T. Yoshimura; Satoshi Yohena; Hideyuki Kodama; Atsushi Hotta; Koki Takahashi; Tetsuya Suzuki
Journal of Biomedical Materials Research Part A | 2007
Terumitsu Hasebe; Satoshi Yohena; Aki Kamijo; Yuko Okazaki; Atsushi Hotta; Koki Takahashi; Tetsuya Suzuki
Surface & Coatings Technology | 2007
Dai Tsubone; Terumitsu Hasebe; Aki Kamijo; Atsushi Hotta
Diamond and Related Materials | 2006
Terumitsu Hasebe; Y. Matsuoka; Hideyuki Kodama; T. Saito; Satoshi Yohena; Aki Kamijo; N. Shiraga; M. Higuchi; Sachio Kuribayashi; Koki Takahashi; Tetsuya Suzuki
Thin Solid Films | 2007
Terumitsu Hasebe; So Nagashima; Aki Kamijo; Taichi Yoshimura; Tetsuya Ishimaru; Yukihiro Yoshimoto; Satoshi Yohena; Hideyuki Kodama; Atsushi Hotta; Koki Takahashi; Tetsuya Suzuki
Surface & Coatings Technology | 2007
T. Hoshida; Dai Tsubone; K. Takada; Hideyuki Kodama; Terumitsu Hasebe; Aki Kamijo; Tetsuya Suzuki; Atsushi Hotta
American Journal of Hematology | 2008
Shinichi Kako; Yoshinobu Kanda; Kumi Oshima; Nahoko Nishimoto; Hiroyuki Sato; Takuro Watanabe; Noriko Hosoya; Toru Motokura; Shigesaburo Miyakoshi; Shuichi Taniguchi; Aki Kamijo; Koki Takahashi; Shigeru Chiba; Mineo Kurokawa