Akihiro Umezawa
Chugai Pharmaceutical Co.
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Publication
Featured researches published by Akihiro Umezawa.
Archive | 2011
Shunichio Miyoshi; Nobuhiro Nishiyama; Naoko Hida; Akihiro Umezawa; Satoshi Ogawa
Umbilical cord blood is medical waste and common allograft cellular source for bone marrow transplantation. It contains a special mesenchymal stem cells, whose cardiomyogenic transdifferentiation efficiency was about 100 times higher than well known marrow-derived mesenchymal stem cells. In this section, we would like to introduce the potential of umbilical cord blood derived mesenchymal stem cell for cardiac stem cell therapy.
Pathology International | 1996
Yoshikiyo Akasaka; Akihiro Umezawa; Hiroshi Suzuki; Tetsuro Sugimoto; Junichi Hata
Monoclonal antibody R4‐A9 demonstrated specificity for a cell surface antigen of stromal cells in murine bone marrow and spleen. In order to Identify patterns of expression that may elucidate the potential role of R4‐A9 antigen, the developmental expression of this antigen in mouse embryos from 8 days post‐coitum to 5 days post‐partum was investigated by immunohistochemistry. At an early developmental stage, weak staining for R4‐A9 antigen could be detected in the yolk sac. At later stages, strong staining of this antigen was detected predominantly in the embryonic liver, the main site of embryonic hematopoiesis. However, concomitant with the decreased staining in the liver, increased expression of this antigen was observed in bone marrow and spleen. Therefore, the changes in expression in those hematopofetic tissues suggest that its expression is coordinately regulated during the developmental stage of the sites of embryonic hematopoiesis. Compared with the distribution of R4‐A9 antigen in adult tissues as previously reported, the expression of this antigen in fetal tissues was more widespread during the period of organogenesis, and was most abundant in other developing tissues, including the heart, skin, and lung. In contrast, fetal expression detected in hematopoietic and other developing tissues was lost after birth. These results taken together show a marked gradient of R4‐A9 antigen expression, with the highest level at the peak of organ development, raising the possibility that this molecule may act as a growth/differentiation factor both in hematopoietic and other developing tissues in a fetus.
Archive | 2000
Akihiro Umezawa; Jun-Ichi Hata; Keiichi Fukuda; Satoshi Ogawa; Kazuhiro Sakurada; Yoji Yamada
Archive | 2000
Akihiro Umezawa; Jun-Ichi Hata; Keiichi Fukuda; Satoshi Ogawa; Kazuhiro Sakurada; Yoji Yamada
Archive | 2006
Akihiro Umezawa; Shunichiro Miyoshi; Satoshi Ogawa
Archive | 2002
Jun-Ichi Hata; Akihiro Umezawa; Tetsuya Tateishi; Takashi Ushida; Guoping Chen
Archive | 2014
Ryuga Ishii; Daisuke Kami; Masashi Toyoda; Hatsune Makino; Toshiharu Ishii; Akihiro Umezawa
Archive | 2013
Yukiji Takeda; Taisuke Mori; Hideaki Imabayashi; Tohru Kiyono; Shunichirou Miyoshi; Naoko Hida; Makoto Ita; Kaoru Segawa; Satoshi Ogawa; Michiie Sakamoto; Shinobu Nakamura; Akihiro Umezawa
Archive | 2000
Akihiro Umezawa; Jun-Ichi Hata; Keiichi Fukuda; Satoshi Ogawa; Kazuhiro Sakurada; Yoji Yamada
Archive | 2000
Akihiro Umezawa; Jun-Ichi Hata; Keiichi Fukuda; Satoshi Ogawa; Kazuhiro Sakurada; Yoji Yamada
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National Institute of Advanced Industrial Science and Technology
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