Akihisa Tsurumoto
Tsurumi University
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Featured researches published by Akihisa Tsurumoto.
Microbiology and Immunology | 1998
Nobuko Maeda; Masaaki Okamoto; Kenichiro Kondo; Hiroyuki Ishikawa; Reiko Osada; Akihisa Tsurumoto; Hiroshi Fujita
The incidence of black‐pigmented rods (BPRs), especially Prevotella intermedia and Prevotella nigrescens, in periodontal health and disease were examined. Furthermore, the degradative enzyme activities of P. intermedia were compared among the strains from periodontal health and disease. Microbiological specimens were collected from subgingival crevice or periodontal pocket by paper point. The BPRs were found in 71.1% of periodontally healthy subjects (n = 45), and in 47.1% of healthy sites (n = 34) and 87.8% of active sites (n = 41) among periodontally diseased patients. Porphyromonas gingivalis was detected only in active sites of periodontally diseased patients (17.8% of 180 strains). P. intermedia was the predominant BPR in both healthy and active sites (37.3 and 41.7%, respectively) of the patients. However, P. nigrescens was the predominant BPR (70.5% of 173 strains) in periodontally healthy subjects. The enzyme activities of esterase, esterase‐lipase, acid‐phosphatase and α‐fucosidase of P. intermedia strains isolated from active sites in patients were significantly higher (P < 0.05) than those of healthy subjects. The results suggest that P. intermedia might increase the activity of degradative enzymes under a certain condition and support the progression of periodontitis.
Gerodontology | 2015
Hisato Kimori; Ken Yamamoto; Shigeo Yamachika; Akihisa Tsurumoto; Yoshiaki Kamikawa; Mami Sasao; Mitsuhiko Morito; Ichiro Saito; Tomoko Ohshima; Nobuko Maeda; Yoichi Nakagawa
PURPOSE This study aimed to identify factors associated with atrophic tongue in patients with dry mouth. METHODS Discriminant analysis was performed in 1265 patients with dry mouth to identify factors that might influence the risk of developing atrophic tongue. The dependent variable was the presence of atrophic tongue, while patient age, resting saliva flow rate, stimulated saliva flow rate and Candida colony-forming units (CFU) were used as the independent variables. RESULTS The standardised linear discriminant coefficients showed that Candida CFU, stimulated saliva flow rate and age were significantly associated with the presence of atrophic tongue. The following linear discriminant function was obtained: z = 0.024 × age - 0.63 × (resting saliva flow rate) - 0.81 × (stimulated saliva flow rate) + 0.002 × Candida CFU - 0.611. CONCLUSION High Candida CFU, low stimulated saliva flow rate and advanced age were identified as closely associated factors for the risk of development of atrophic tongue.
Gerodontology | 2013
Mariko R. Okamoto; Miho Kamoi; Shigeo Yamachika; Akihisa Tsurumoto; Takahiro Imamura; Ken Yamamoto; Shinichi Kadomatsu; Ichiro Saito; Nobuko Maeda; Yoichi Nakagawa
OBJECTIVE The purpose of this study was to investigate the efficacy of Fungiflora Y staining (fluorescent stain) for the diagnosis of erythematous candidiasis. SUBJECTS AND METHODS This study enrolled 48 patients who were diagnosed with erythematous candidiasis and who underwent fungal culture and microscopic examination of a smear specimen stained with CytoQuick (modification of the Giemsa stain) and Fungiflora Y. Fungiflora Y staining was observed using a portable fluorescent microscope (CyScope(®)). The sensitivity, specificity and positive and negative predictive values were calculated using fungal culture as the gold standard test. Accuracy was calculated, and the difference between the CytoQuick and Fungiflora Y groups was examined using contingency tables and the chi-square test. RESULTS The sensitivity and specificity of the CytoQuick stain was 0.51 and 0.91, respectively; the positive predictive value was 0.95, and the negative predictive value was 0.36. The sensitivity and specificity of the Fungiflora Y stain was 0.84 and 1.0, respectively; the positive predictive value was 1.00, and the negative predictive value was 0.65. The accuracy of Fungiflora Y (0.88) was superior to that of CytoQuick (0.60) (p = 0.0052). CONCLUSIONS Microscopic examinations of smear specimens using a combination of Fungiflora Y staining and the CyScope(®) portable fluorescent microscope was found to be useful for the diagnosis of oral erythematous candidiasis.
BMC Oral Health | 2017
Sachika Nakamura; Mariko R. Okamoto; Ken Yamamoto; Akihisa Tsurumoto; Yoko Yoshino; Hiroshi Iwabuchi; Ichiro Saito; Nobuko Maeda; Yoichi Nakagawa
BackgroundThe purpose of this study was to clarify the species of Candida that are important for the development of atrophic glossitis in xerostomia patients.MethodsA total of 231 patients with subjective dry mouth were enrolled in the present study. Logistic regression analysis was performed to clarify the contribution of each Candida species and other variables to the development of atrophic glossitis. The dependent variable was the absence/presence of atrophic glossitis. The Candida colony-forming units (CFU) of C. albicans, C. glabrata, C. tropicalis, and C. krusei, as well as age, gender, resting (RSFR) and stimulated (SSFR) whole salivary flow rate, and denture-wearing status, were treated as explanatory variables.ResultsLogistic regression analysis showed that two factors were closely associated with the presence of atrophic glossitis: an increase in C. albicans CFU and a decrease in the SSFR.ConclusionsC. albicans, but not non-albicans Candida, was associated with atrophic glossitis in xerostomia patients who had no systemic predisposing factors, indicating that C. albicans remains a treatment target for Candida-related atrophic glossitis.
Pediatric Dental Journal | 2004
Yoshiaki Nomura; Akihisa Tsurumoto; Fusao Nishikawara; Mizuho Motegi; Nobuhiro Hanada; Takashi Kumagai
Abstract Regular check-ups are important for reducing the risk factors of dental caries. Through regular check-ups, clinicians empirically know that the incidence of the new dental caries was suppressed. However, the effects of the regular check-up system have not been thoroughly evaluated. Our primary concern was to evaluate the efficacy of the regular check-up system with professional preventive care for preventing dental caries. In this study, we evaluated attitudes toward regular check-ups. Five hundred and thirteen patients who visited one dental office in Japan from 1981 to 2000 and who were under 12 on the first visit were examined for dental caries, salivary mutans streptococci, and Lactobacilli to obtain baseline values and the values for the more recent visit analyzed in this study. Salivary mutans streptococci and Lactobacilli were counted using Dentocult SM and Dentocult LB. Most of the risk factors, particularly the salivary levels of the mutans streptococci, were reduced by regular check-ups in this study. There was a greater risk reduction in particular for the salivary levels of mutans streptococci in patients undertaking regular check-ups. Reduced salivary levels of Lactobacilli were also observed. However, the changes between the groups in the attitude toward regular check-ups were not statistically significant. This result indicates that most of the risk factors investigated in this study could be reduced by regular check-ups, particularly the levels of mutans streptococci, which has been suggested to be a strong etiology of dental caries.
Journal of Oral Science | 2006
Yoshiaki Nomura; Yoh Tamaki; Tomoko Tanaka; Hirohisa Arakawa; Akihisa Tsurumoto; Kazuko Kirimura; Tsutomu Sato; Nobuhiro Hanada; Kyuichi Kamoi
Journal of Periodontology | 2001
Makoto Kawamura; Akihisa Tsurumoto; Setsuko Fukuda; Hisako Sasahara
Journal of Oral Science | 2004
Yoh Tamaki; Yoshiaki Nomura; Kayo Teraoka; Fusao Nishikahara; Mizuho Motegi; Akihisa Tsurumoto; Nobuhiro Hanada
Journal of Oral Science | 2005
Yoh Tamaki; Yoshiaki Nomura; Fusao Nishikawara; Mizuho Motegi; Kayo Teraoka; Hirohisa Arakawa; Akihisa Tsurumoto; Nobuhiro Hanada
Journal of Oral Science | 2000
Makoto Kawamura; C. David L. Thomas; Akihisa Tsurumoto; Hisako Sasahara; Yoko Kawaguchi