Akihito Okazaki
Kanazawa University
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Publication
Featured researches published by Akihito Okazaki.
Lung Cancer | 2013
Satoshi Watanabe; Takashi Sone; Tomoharu Matsui; Kenta Yamamura; Mayuko Tani; Akihito Okazaki; Koji Kurokawa; Yuichi Tambo; Hazuki Takato; Noriyuki Ohkura; Yuko Waseda; Nobuyuki Katayama; Kazuo Kasahara
We report the case of a 52-year-old woman with lung adenocarcinoma treated with EGFR tyrosine kinase inhibitor (TKI) therapy. After disease progression, histological examination of a secondary biopsy specimen revealed small-cell lung cancer (SCLC) that was sensitive to standard SCLC treatment. Tumor markers, including ProGRP and NSE, were elevated. Transformation to SCLC is a mechanism for acquired resistance to EGFR-TKI therapy. Secondary biopsy is important for evaluation of genetic and histological changes and selection of appropriate treatment. Furthermore, ProGRP and NSE may be useful for early detection of SCLC transformation in cases resistant to EGFR-TKI therapy.
Respirology | 2012
Noriyuki Ohkura; Masaki Fujimura; Yusuke Nakade; Akihito Okazaki; Nobuyuki Katayama
Background and objective: The pathophysiology of cough variant asthma (CVA) is poorly understood. We compared bronchoconstriction‐triggered cough between CVA patients and normal control (NC) subjects.
Journal of Infection and Chemotherapy | 2013
Akihito Okazaki; Hazuki Takato; Masaki Fujimura; Noriyuki Ohkura; Nobuyuki Katayama; Kazuo Kasahara
We describe a 50-year-old woman with rapidly progressive pulmonary Mycobacterium abscessus (M. abscessus) infection accompanied by pleural effusion and organizing pneumonia (OP). CT scan showed consolidation, centrilobular shadows, ground-glass opacity (GGO), and cavities. A transbronchial lung biopsy showed nonnecrotizing granuloma surrounded by infiltrative lymphocyte-dominant inflammatory cells, and lymphocytes in bronchoalveolar lavage fluid (BALF) were increased. We considered OP occurred secondary to M. abscessus infection because clarithromycin, amikacin, and imipenem/cilastatin administration resulted in partial improvement. We added corticosteroids to the regimen, which resulted in a remarkable improvement. We report a case of pulmonary M. abscessus infection involving pleural effusion that responded favorably to medical therapy including corticosteroids.
Journal of Infection and Chemotherapy | 2016
Akihito Okazaki; Satoshi Watanabe; Taro Yoneda; Johsuke Hara; Masaru Nishitsuji; Koichi Nishi; Kazuo Kasahara
Paradoxical reactions (PRs) to antituberculosis (anti-TB) drugs during treatment are well known phenomena, but a PR presenting as a new pulmonary lesion after completion of treatment is extremely rare, and little is known about the management of such cases. A 44-year-old man was diagnosed with pulmonary TB. His sputum cultures became negative 45 days after the initiation of standard anti-TB treatment. Upon the patients completion of 6 months of anti-TB therapy, computed tomography revealed a new irregularly shaped mass in the lower left pulmonary lobe. A transbronchial lung biopsy (TBLB) revealed caseous necrosis and granulomatosis surrounded by epithelioid and multinucleated giant cells. Cultures of both the TBLB specimen and bronchoalveolar lavage fluid remained negative for TB. The CT shadow disappeared 6 months later without further administration of anti-TB drugs. Careful observation without therapy may be sufficient for a patient treated for TB who develops a PR upon completion of treatment, if the patient has achieved a bacteriological remission.
Experimental Lung Research | 2016
Noriyuki Ohkura; Johsuke Hara; Tamami Sakai; Akihito Okazaki; Miki Abo; Kazuo Kasahara; Masaki Fujimura
ABSTRACT Background: Atopic cough (AC) and cough variant asthma (CVA) were identified as major causes of chronic non-productive cough in a Japanese study. A characteristic feature of CVA is the presence of a heightened cough response to bronchoconstriction. On the other hand, the cough response to bronchoconstriction in AC remains unclear. Methods: Methacholine (Mch)-induced cough in AC was measured and compared with that in CVA. Diagnoses of AC and CVA were made based on patient history, physical examination, response to bronchodilator therapy, cough reflex sensitivity to capsaicin, spirometry, and airway responsiveness to methacholine. Results: Thirteen AC patients and 12 CVA patients in whom the criteria were met were recruited to the study. After inhalation of Mch at PC35-PEF40 that means milder bronchoconstriction than PC20-FEV1, cough was triggered a few times in AC. [cough number: 1/ 32 min (0–40)]. Conversely, significantly greater number of coughs was provoked in CVA, compared with AC [cough number: 35.5/ 32 min (25-125), p < 0.05]. Conclusions: The cough response to bronchoconstriction is reduced in AC compared to CVA. This feature may be useful in the diagnosis of chronic cough.
Haigan | 2016
Taisuke Isono; Akihito Okazaki; Mizuki Yuasa; Mayuka Uo; Masaru Nishitsuji; Koichi Nishi
/data/revues/10945539/v26i5/S1094553913001399/ | 2013
Akihito Okazaki; Noriyuki Ohkura; Masaki Fujimura; Nobuyuki Katayama; Kazuo Kasahara
Haigan | 2012
Akihito Okazaki; Tomoyuki Araya; Asao Sakai; Takashi Sone; Kazuo Kasahara; Masaki Fujimura
European Respiratory Journal | 2012
Satoshi Watanabe; Yuichi Tambo; Yuko Waseda; Ryo Matsunuma; Hazuki Takato; Kanako Inuzuka; Akihito Okazaki; Nobuyuki Katayama; Masahide Yasui; Kazuo Kasahara; Masaki Fujimura