Akiko Ido
Gifu Pharmaceutical University
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Featured researches published by Akiko Ido.
Chemosphere | 2013
Akiko Ido; Shinji Ishihara; Akira Kume; Tsuyoshi Nakanishi; Yasunari Monguchi; Hironao Sajiki; Hisamitsu Nagase
Polychlorinated biphenyls (PCBs) were mainly used as lubricants and coolants in electrical equipment. However, their chemical stabilities as well as hydrophobic properties caused persistent environmental pollution and damage to human health based on their bioaccumulative property. PCBs are currently targeted for worldwide elimination and should be disposed by 2028 based on the Stockholm Convention on Persistent Organic Pollutants. The conventional PCB degradation methods require high-heat, high-pressure or/and strongly basic conditions. The development of a safer and more practical method, therefore, is desired. We have reported a catalytic degradation method of PCBs based on a palladium on carbon (Pd/C)-catalyzed dechlorination in the presence of Et(3)N under ambient hydrogen pressure and temperature. In this study, we demonstrate a more practical system using magnesium metal instead of Et(3)N for the dechlorination of a variety of aromatic chlorides. The method was applicable for the complete degradation of a variety of PCB mixtures, such as Aroclor 1242, 1248, 1254 and PCBs removed from a capacitor to produce only biphenyl and magnesium chloride as the maritime component, both of which are less toxic and easily separable. Moreover, the Pd/C could be recovered and reused at least five times without any loss of catalytic activity. The present Pd/C-Mg-H(2) system is a simple, safe, inexpensive, and environmentally-benign degradation method of PCBs.
Journal of Hazardous Materials | 2012
Shinji Ishihara; Akiko Ido; Yasunari Monguchi; Hisamitsu Nagase; Hironao Sajiki
The simultaneous use of catalytic amount of palladium on carbon (Pd/C) and Mg metal (1.5-2.0 equiv vs. Cl numbers of the substrates) in MeOH achieved the complete dechlorination of a variety of aryl chlorides at room temperature under a nitrogen atmosphere in the absence of hydrogen gas. The present method could be successfully used for the detoxification of PCBs based on the dechlorination reaction. Both virgin PCBs, such as Aroclors 1242, 1248 and 1254, and used PCBs as a high-tension capacitor oil, were smoothly dechlorinated into harmless biphenyl without any byproducts within 2h at rt. The distinctive features of this method are convenience and safety due to no needs for the pretreatment of catalyst and Mg and complete degradation of PCBs under mild conditions without hydrogen gas.
Scientific Reports | 2017
Akiko Ido; Youhei Hiromori; Liping Meng; Haruki Usuda; Hisamitsu Nagase; Min Yang; Jianying Hu; Tsuyoshi Nakanishi
Fibrates, which are widely used lipidaemic-modulating drugs, are emerging environmental pollutants. However, fibrate concentrations in the environment have not been thoroughly surveyed. Here, we determined concentrations of the most commonly used fibrates and their metabolites in source water and drinking water samples from ten drinking water treatment plants in Shanghai and Zhejiang, China, using solid-phase extraction and liquid chromatography–tandem mass spectrometry. All the target compounds were detected in at least some of the source water samples, at concentrations ranging from 0.04 ng/L (fenofibrate) to 1.53 ng/L (gemfibrozil). All the compounds except fenofibrate were also detected in at least some of the drinking water samples, at recoveries ranging from 35.5% to 91.7%, suggesting that these compounds are poorly removed by typical drinking water treatment processes. In a peroxisome proliferator-activated receptor α agonistic activity assay, the target compounds showed no significant activity at nanogram per litre concentrations; therefore, our results suggest that the fibrate concentrations in drinking water in Shanghai and Zhejiang, China do not significantly affect human health. However, because of the increasing westernization of the Chinese diet, fibrate use may increase, and thus monitoring fibrate concentrations in aquatic environments and drinking water in China will become increasingly important.
Organic Process Research & Development | 2010
Yasunari Monguchi; Shinji Ishihara; Akiko Ido; Miki Niikawa; Koichi Kamiya; Yoshinari Sawama; Hisamitsu Nagase; Hironao Sajiki
Archive | 2009
Hisamitsu Nagase; Hironao Sajiki; Yasunari Monguchi; Tomohiro Maegawa; Akiko Ido; Sueo Wada; Shinji Ishihara
Iranian Journal of Environmental Health Science & Engineering | 2015
Akiko Ido; Miki Niikawa; Shinji Ishihara; Yoshinari Sawama; Tsuyoshi Nakanishi; Yasunari Monguchi; Hironao Sajiki; Hisamitsu Nagase
Heterocycles | 2015
Hironao Sajiki; Yasunari Monguchi; Akiko Ido; Miki Niikawa; Nobuharu Nagatsu; Ryosuke Mizukoshi; Hisamitsu Nagase
Fundamental Toxicological Sciences | 2017
Erina Shiraishi; Akiko Ido; Youhei Hiromori; Kento Tanaka; Tomoki Kimura; Hisamitsu Nagase; Tsuyoshi Nakanishi
Biological & Pharmaceutical Bulletin | 2016
Youhei Hiromori; Akiko Ido; Akira Aoki; Tomoki Kimura; Hisamitsu Nagase; Tsuyoshi Nakanishi
Heterocycles : an international journal for reviews and communications in heterocyclic chemistry | 2015
Yasunari Monguchi; Akiko Ido; Miki Niikawa