Akiko Makiuchi
Shinshu University
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Publication
Featured researches published by Akiko Makiuchi.
Circulation | 2004
Kazuhiro Yamaura; Ken-ichi Ito; Katsuaki Tsukioka; Yuko Wada; Akiko Makiuchi; Masayuki Sakaguchi; Tomohiro Akashima; Minoru Fujimori; Yoshiki Sawa; Ryuichi Morishita; Kunio Matsumoto; Toshikazu Nakamura; Jun-ichi Suzuki; Jun Amano; Mitsuaki Isobe
Background—Although treatment with immunosuppressive agents has contributed to overcoming acute rejection and improving the midterm survival of transplanted hearts, cardiac allograft vasculopathy (CAV) has remained the main cause of primary graft failure. Recent approaches have shown that hepatocyte growth factor (HGF) exhibits cardiotrophic functions. We therefore addressed whether HGF would regulate acute and chronic rejection in cardiac transplantation. Methods and Results—We used a murine heterotopic cardiac transplantation model between fully incompatible strains and administered 500 &mgr;g · kg−1 · d−1 HGF during the initial 14 days after transplantation. The HGF-treated allografts showed significantly prolonged survival (42.3±4.1 days, P<0.001) compared with the controls (11.1±0.6 days), with tolerance induction in 47.4%. Histopathologically, the number of infiltrating cells was significantly decreased and myocardial necrosis was less prominent with a reduction of apoptosis in the allografts by HGF treatment during acute rejection. In the long-term surviving allografts, HGF significantly inhibited the development of CAV and interstitial fibrosis. With respect to intragraft cytokine mRNA expression, HGF treatment reduced the early expression of interferon-&ggr; and enhanced the expression of transforming growth factor-&bgr;1 during the acute phase and of interleukin-10 continuously through the acute phase to the chronic phase. Conclusions—Our findings demonstrate that HGF can prolong the survival of allografts by its cardioprotective and immunomodulative potencies. Thus, HGF administration may constitute a new therapeutic approach to preventing cardiac graft failure that has not been overcome by conventional immunosuppressive agents.
Interactive Cardiovascular and Thoracic Surgery | 2010
Takashi Eguchi; Nobuo Ito; Akiko Makiuchi; Kazuo Yoshida
Solitary fibrous tumors (SFTs) are localized mesenchymal lesions which most frequently arise in the pleura but have also been observed in many other sites. SFTs arising from the thymus are relatively rare, however, and only a few cases have been reported to date. We report such a case in our current study.
Journal of Thoracic Imaging | 2000
Masayuki Haniuda; Hiroki Numanami; Akiko Makiuchi; Takeshi Yamanda; Yutaka Imai; Shusuke Sone
Two cases of isolated saccular aneurysms of the innominate vein are presented that appeared as mediastinal masses. Contrast-enhanced computed tomography (CT) allowed for accurate diagnosis in one patient, while the second patient had atypical CT findings that led to thoracotomy for proper diagnosis. A diagnosis of innominate vein aneurysm should be considered when a uniform attenuation mediastinal mass is seen on CT so that unnecessary biopsy and surgery can be avoided.
The Japanese Journal of Thoracic and Cardiovascular Surgery | 2002
Makoto Kurai; Masayuki Haniuda; Takeshi Yamanda; Akiko Makiuchi; Takehiko Sakai; Jun Amano
Myxoma protruding from the chest wall into the thoracic cavity is very rare. We report our experience in treating a 42-year-old man admitted for a painless mass on the anterior chest wall. Magnetic resonance imaging showed a sharply defined 5 x 4 x 4 cm mass protruding from the chest wall into the thoracic cavity, which we excised surgically. Histologically, the tumor proved to be a myxoma.
Journal of Surgical Oncology | 2001
Masayuki Haniuda; Ryoichi Kondo; Hiroki Numanami; Akiko Makiuchi; Emi Machida; Jun Amano
Journal of Heart and Lung Transplantation | 2007
Akiko Makiuchi; Kazuhiro Yamaura; Shinya Mizuno; Kunio Matsumoto; Toshikazu Nakamura; Jun Amano; Ken-ichi Ito
Hepato-gastroenterology | 2000
Kazuhiro Hanazaki; Wakabayashi M; Akiko Makiuchi; Jun Igarashi; Harutsugu Sodeyama; Shuichi Wada; Jun Amano
Hepato-gastroenterology | 1998
Kazuhiro Hanazaki; Wakabayashi M; Harutsugu Sodeyama; Akiko Makiuchi; Jun Igarashi; Shiro Yokoyama; Sode Y; Nobuyuki Kawamura; Tadaaki Miyazaki
Haigan | 2001
Takeshi Yamanda; Takayuki Shiina; Akiko Makiuchi; Makoto Kurai; Ryouichi Kondo; Hiroki Numanami; Keiichiro Takasuna; Emi Machida; Masayuki Haniuda; Jun Amano
The Journal of The Japanese Association for Chest Surgery | 1999
Keiichirou Takasuna; Takeshi Yamanda; Akiko Makiuchi; Ryouichi Kondo; Hiroki Numanami; Takaomi Hanaoka; Emi Machida; Masahisa Miyazawa; Kazuo Yoshida; Takahisa Aoki; Masayuki Haniuda; Jun Amano